Circ_KIAA0922 regulates Saos-2 cell proliferation and osteogenic differentiation by regulating the miR-148a-3p/SMAD5 axis and activating the TGF-β signaling pathway [0.03%]
circ_KIAA0922通过调节miR-148a-3p/SMAD5轴和激活TGF-β信号通路调控Saos-2细胞增殖及成骨分化
Shanshan Zhang,Yongtao Zhang,Dan Yang et al.
Shanshan Zhang et al.
Circular RNAs (circRNAs) are emerging as important regulators in human disease, but their function in osteoporosis (OP) is not sufficiently known. The aim of this study was to identify the possible molecular mechanism of circ_KIAA0922 in os...
Wenli Zhang,Yifan Li,Wentao Ren et al.
Wenli Zhang et al.
Alzheimer's disease is a neurocognitive disorder and one of the contributing factors to dementia. According to the World Health Organization, this disease has a sig-nificant impact on the global population's health, with the number of affec...
Mi Tang,Yan Yang,Ziping Ye et al.
Mi Tang et al.
On September 18, 2023, the National Health Commission of China officially announced the "Second List of Rare Diseases". This list of 86 rare diseases, drafted in accordance with the "Working Procedures for Drafting the List of Rare Diseases...
Pathologic features and clinical treatment of sarcomatoid intrahepatic cholangiocarcinoma [0.03%]
肉瘤样肝内胆管癌的病理特征和临床治疗
Xiaoli Xie,Nannan Lai,Yuanyuan Yang et al.
Xiaoli Xie et al.
The current study examined sarcomatoid intrahepatic cholangiocarcinoma (S-iCCA). S-iCCA was a more aggressive subtype of intrahepatic cholangiocarcinoma (iCCA). Early detection and complete resection of tumors are very important. Reported h...
Vosoritide, a miracle drug, covering unmet need in achondroplasia: A regulatory update [0.03%]
vosoritide，一种治疗软骨发育不全的“神药”：监管更新
Simran,Kirthiga Devi S S,Sabanis Chetan Dushantrao et al.
Simran et al.
Dwarfism is a rare condition characterized by small stature. Achondroplasia is predominantly considered the leading cause of dwarfism. Although the condition is not life-threatening, it dramatically impacts the social life of the patient. T...
Expression of collagen-related piRNA is dysregulated in cultured dermal fibroblasts derived from patients with scleroderma [0.03%]
系统自动摘要：硬皮病患者皮肤成纤维细胞中胶原相关piRNA表达异常
Minako Tanaka,Yutaka Inaba,Azusa Yariyama et al.
Minako Tanaka et al.
PIWI-interacting RNA (piRNA) is a class of recently discovered small non-coding RNAs. piRNAs derive from an initial transcript encompassing a piRNA cluster via a unique biosynthesis process, interact with PIWI proteins, bind to specific tar...
Trofinetide in Rett syndrome: A brief review of safety and efficacy [0.03%]
雷特综合征中特罗 finetide的安全性和有效性的简要回顾
Alok Singh,Mahesh Kumar Balasundaram,Dhyuti Gupta
Alok Singh
Rett syndrome (RTT) is a rare genetic neurological disorder that primarily affects girls and is caused by mainly mutations in the methyl-CpG-binding protein 2 (MECP2) gene, leading to critical issues in normal brain function. The condition ...
Identification of novel and de novo GABRB1 mutation in Chinese patient with developmental and epileptic encephalopathy 45 [0.03%]
在中国发育性和癫痫性脑病患者中鉴定GABRB1的新突变和新生突变
Shanshan Zhang,Yu Wang,Meilin Liu et al.
Shanshan Zhang et al.
Developmental and epileptic encephalopathy 45 (DEE45) is an autosomal dominant disease caused by variation in the gamma-aminobutyric acid type A receptor subunit beta 1 (GABRB1) gene. Affected individuals have severely impaired intellectual...
Herpes zoster peripheral nerve complications: Their pathophysiology in spinal ganglia and nerve roots [0.03%]
带状疱疹外周神经并发症：脊髓神经节和神经根中的病理生理学
Hiroshi Shoji,Kouki Matsuo,Tomonaga Matsushita et al.
Hiroshi Shoji et al.
Varicella zoster virus (VZV) causes chickenpox at the primary infection and then becomes latent in the spinal dorsal root ganglia; VZV can reactivate with aging, immunosuppression, stress, and other factors, occurring as herpes zoster (HZ) ...
Senol Kobak
Senol Kobak
VEXAS syndrome, is a hemato-inflammatory chronic disease characterized with predominantly rheumatic and hematologic systemic involvement. It was first described in 2020 by a group of researchers in the United States. VEXAS syndrome is a rar...