Clozapine-induced myocarditis: Two case reports and review of clinical presentation and recognition [0.03%]
氯氮平致心肌炎的两例报道及临床表现和认识的复习
Bryan K Sackey,Troy A Moore,Nicole L Cupples et al.
Bryan K Sackey et al.
Myocarditis is a potentially fatal cardiac disease marked by inflammation of the heart muscle. With a noted black-box warning, rates of clozapine-induced myocarditis are reportedly as high as 3%. Since the first case of clozapine-induced my...
The use of pharmacogenetic testing in patients with schizophrenia or bipolar disorder: A systematic review [0.03%]
精神分裂症或双相情感障碍患者中药物基因组检测的应用：一项系统综述
Melanie Routhieaux,Jessica Keels,Erika E Tillery
Melanie Routhieaux
Introduction: Pharmacogenetic testing may assist in identifying an individual's risk of developing a mental illness as well as predict an individual's response to treatment. The objective of this study is to report publis...
Pharmacologic management of behavioral and psychological symptoms of major neurocognitive disorder [0.03%]
重大神经认知障碍的行为和心理症状的药理学管理
Monica Mathys
Monica Mathys
Behavioral and psychological symptoms of dementia (BPSD) occur in approximately 80% of patients who receive a diagnosis of major neurocognitive disorder. Nonpharmacologic strategies are the first-line treatment for BPSD. However, psychotrop...
Sandra Mullen
Sandra Mullen
Major depressive disorder (MDD) is one of the most common psychiatric disorders of childhood and adolescence, but because of symptom variation from the adult criteria, it is often unrecognized and untreated. Symptom severity predicts the in...
Recognition and treatment of mood dysregulation in adults with intellectual disability [0.03%]
智力障碍成年人情绪失调节的识别与治疗
Jason Noel
Jason Noel
Mood dysregulation is a common feature in the psychopathology of people with intellectual disability (ID) and co-occurring behavioral/psychiatric disorders. It can present with a host of dangerous behaviors, including aggression, self-injur...
Carol A Ott
Carol A Ott
Anxiety disorders are the most prevalent comorbid diagnoses in patients with bipolar disorder (BD). A comorbid anxiety diagnosis can significantly impact the severity of bipolar symptoms, increase the risk of suicidality, and decrease psych...
Utilization of G-CSF and GM-CSF as an alternative to discontinuation in clozapine-induced neutropenia or leukopenia: A case report and discussion [0.03%]
粒细胞集落刺激因子和粒细胞-巨噬细胞集落刺激因子用于氯氮平所致中性粒细胞减少症或白细胞减少症的继续用药：病例报告及讨论
Allison Karst,Jonathan Lister
Allison Karst
Clozapine remains the definitive gold standard for treatment-resistant schizophrenia despite limitations in use because of hematological abnormalities. Neutropenia or leukopenia are often treated with interruption of clozapine treatment, fr...
Jennifer Houser,Ashley Graham
Jennifer Houser
Lamotrigine (LTG) is associated with the potential for a life-threatening rash (eg, Stevens-Johnson syndrome or toxic epidermal necrolysis). The incidence has been linked to rapid titration and an interaction with valproic acid that can inc...
Gary Burdge,Henry Leach,Kim Walsh
Gary Burdge
Ziconotide is an intrathecally administered medication indicated for the treatment of severe chronic pain in patients who are intolerant of or refractory to other treatment options. A black box warning is included in the packaging and state...
Tonya Gross,Jeremy Daniel
Tonya Gross
Introduction: Pharmacogenomic tests relevant to neuropsychiatric medications have been clinically available for more than a decade, but the utility of regular testing is still unknown. Tests available include both pharmac...