Investigation of the Influencing Factors on the Incidence of Vertebral Fracture: A Meta-analysis Based on Placebo Data of Randomized Clinical Trials [0.03%]
基于随机对照试验安慰剂数据的椎体骨折影响因素研究—— meta 分析报告
Tsuyoshi Kobayashi,Masayuki Kaneko,Mamoru Narukawa
Tsuyoshi Kobayashi
Background: The incidence of vertebral fracture is commonly used as a primary endpoint in randomized clinical trials of pharmaceutical agents for osteoporosis. In order to investigate the impact of ethnic/regional differe...
Leveling the Joint Task Force Core Competencies for Clinical Research Professionals [0.03%]
临床研究人员联合工作组核心能力水平标准制定
Stephen A Sonstein,Rebecca J Namenek Brouwer,William Gluck et al.
Stephen A Sonstein et al.
Competency standards for clinical research professionals are being developed across the enterprise, based largely on the Core Competency Framework put forth by the Joint Task Force for Clinical Trial Competency (JTF). In late 2016, represen...
Leveling the Joint Task Force Core Competencies for Clinical Research Professionals [0.03%]
临床研究人员联合工作组核心胜任力的分级
Stephen A Sonstein,Rebecca J Namenek Brouwer,William Gluck et al.
Stephen A Sonstein et al.
Competency standards for clinical research professionals are being developed across the enterprise, based largely on the Core Competency Framework put forth by the Joint Task Force for Clinical Trial Competency (JTF). In late 2016, represen...
Tenders for the Procurement of Medical Devices: Adapting Cost-Effectiveness Rules to the Requirements of the European Public Procurement Directive [0.03%]
医疗设备采购的招标：修订成本效益规则以符合欧洲公共采购指令的要求
Andrea Messori,Sabrina Trippoli,Erminia Caccese et al.
Andrea Messori et al.
Background: In evaluating 3 or more comparators, pharmacoeconomic analyses can be improved by using the methodology of net monetary benefit (NMB) as opposed to incremental cost-effectiveness ratio (ICER). NMB is particula...
Tenders for the Procurement of Medical Devices: Adapting Cost-Effectiveness Rules to the Requirements of the European Public Procurement Directive [0.03%]
医疗设备采购招标：修订成本效益规则以符合欧洲公共采购指令的要求
Andrea Messori,Sabrina Trippoli,Erminia Caccese et al.
Andrea Messori et al.
Background: In evaluating 3 or more comparators, pharmacoeconomic analyses can be improved by using the methodology of net monetary benefit (NMB) as opposed to incremental cost-effectiveness ratio (ICER). NMB is particula...
Measuring the Impact of Patient Engagement and Patient Centricity in Clinical Research and Development [0.03%]
临床研究和开发中患者参与和以患者为中心的影响评估
Stella Stergiopoulos,Debra L Michaels,Barbara Lopez Kunz et al.
Stella Stergiopoulos et al.
Background: Recently, drug development companies have sought out patient feedback to improve overall drug development. However, characterization of the overall impact and return on engaging with patients have not been det...
Measuring the Impact of Patient Engagement and Patient Centricity in Clinical Research and Development [0.03%]
临床研究和发展中患者参与和以患者为中心的影响评估方法
Stella Stergiopoulos,Debra L Michaels,Barbara Lopez Kunz et al.
Stella Stergiopoulos et al.
Background: Recently, drug development companies have sought out patient feedback to improve overall drug development. However, characterization of the overall impact and return on engaging with patients have not been det...
Adaptive Design: A Review of the Technical, Statistical, and Regulatory Aspects of Implementation in a Clinical Trial [0.03%]
自适应设计的回顾：临床试验实施的技术、统计和监管因素综述
Franck Pires Cerqueira,Angelo Miguel Cardoso Jesus,Maria Dulce Cotrim
Franck Pires Cerqueira
Background: In an adaptive trial, the researcher may have the option of responding to interim safety and efficacy data in a number of ways, including narrowing the study focus or increasing the number of subjects, balanci...
Adaptive Design: A Review of the Technical, Statistical, and Regulatory Aspects of Implementation in a Clinical Trial [0.03%]
自适应设计：临床试验实施中的技术、统计和监管要素综述
Franck Pires Cerqueira,Angelo Miguel Cardoso Jesus,Maria Dulce Cotrim
Franck Pires Cerqueira
Background: In an adaptive trial, the researcher may have the option of responding to interim safety and efficacy data in a number of ways, including narrowing the study focus or increasing the number of subjects, balanci...
Updating the Clinical Picture of Facioscapulohumeral Muscular Dystrophy: Ramifications for Drug Development With Potential Solutions [0.03%]
改变面肩肱肌营养不良的临床图景：对药物开发的影响及潜在解决方案
Raymond A Huml,Olga Uspenskaya-Cadoz,Jill Dawson et al.
Raymond A Huml et al.
Background: Facioscapulohumeral muscular dystrophy (FSHD) is a complex, inheritable, and rare muscle disease that affects the entire body. The major symptom of FSHD is progressive weakening and loss of skeletal muscles. T...