Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Dupilumab on Pre-Bronchodilator Forced Expiratory Volume in 1 Second (FEV1) in Uncontrolled Moderate-To-Severe Asthma [0.03%]
度匹利尤单抗对未使用支气管扩张剂的第1秒用力呼气容积（FEV1）的影响的以人群为基础的半机制药代动力学/药效学（PK/PD）模型研究：中至重度控制不佳型哮喘患者的模拟分析
Li Zhang,John D Davis,Vanaja Kanamaluru et al.
Li Zhang et al.
In this study, we investigated the pharmacokinetic/pharmacodynamic (PK/PD) relationship of dupilumab as an add-on therapy in the intent-to-treat (ITT) uncontrolled moderate-to-severe asthma population and identified the factors significantl...
Evaluation of Four Semi-Mechanistic Models for Predicting Glycemic Control With a Glucagon Receptor Antagonist in People With Type 2 Diabetes [0.03%]
四种半机制模型预测胰高血糖素受体拮抗剂改善2型糖尿病患者血糖控制的评估研究
Austin Yue Feng Tan,Karen Schneck,Parag Garhyan et al.
Austin Yue Feng Tan et al.
Glycated hemoglobin (HbA1c) is the gold standard for measuring long-term glycemic efficacy over at least 3 months in Type 2 diabetes (T2D). Being able to predict HbA1c using glucose response from studies of less than 3 months would be usefu...
Development and Verification of a Physiologically Based Pharmacokinetic Model of Furmonertinib and Its Main Metabolite for Drug-Drug Interaction Predictions [0.03%]
用于药物相互作用预测的福莫替尼及其主要代谢产物的生理药动学模型的建立与验证
Yali Wu,Helena Leonie Hanae Loer,Yifan Zhang et al.
Yali Wu et al.
Furmonertinib demonstrated potent efficacy as a newly developed tyrosine kinase inhibitor for the treatment of patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer. In vitro research showed that...
A Quantitative Systems Pharmacology Model That Describes Neurofilament Light Dynamics During Alzheimer's Disease Progression [0.03%]
一种定量系统药理学模型 描述阿尔茨海默病进展过程中的神经丝轻链动态变化
Polina Maliukova,Tatiana Karelina
Polina Maliukova
Neurofilament proteins are important constituents of neuronal cytoskeleton, along with microtubules. An increased concentration of neurofilament light (NfL) protein in cerebrospinal fluid (CSF) and plasma is considered a potential biomarker...
Tutorial for Modeling Delays in Biological Systems in the NONMEM Software [0.03%]
药物动力学中NONMEM软件延迟能力的教程研究
Robert J Bauer,Wojciech Krzyzanski
Robert J Bauer
Delays in biological systems are a common phenomenon. The models for delays require specialized mathematical and numerical techniques such as transit compartments, delay differential equations (DDEs), and distributed DDEs (DDDEs). Because o...
Viral Dynamic Models During COVID-19: Are We Ready for the Next Pandemic? [0.03%]
新冠肺炎期间的病毒动态模型：我们为下一次大流行病做好准备了吗？
Aurelien Marc,Joshua T Schiffer,France Mentré et al.
Aurelien Marc et al.
Mathematical models have been used for about 30 years to improve our understanding of virus-host interaction, in particular during chronic infections. During the COVID-19 pandemic, these models have been used to provide insights into the na...
Population Pharmacokinetics and Exposure-Response Relationship of Hemoporfin in Pediatric Patients With Port-Wine Stain [0.03%]
用于治疗葡萄酒色癍患儿的海姆泊芬群体药代动力学及暴露反应关系研究
Rong Chen,Bin Zhang,Jining Tao et al.
Rong Chen et al.
Hemoporfin, a porphyrin derivative photosensitizer, has been approved for the treatment of port-wine stain (PWS) in adults. However, its optimal dose for the pediatric population remains unclear. This study aimed to explore appropriate dosi...
Examining the Reliability of Model-Based Meta-Analysis (MBMA) Outcomes: A Simulation Study [0.03%]
基于模型的Meta分析（MBMA）结果可靠性的检验：一项模拟研究
Jiesen Yu,Ting Li,Jieren Luo et al.
Jiesen Yu et al.
Model-based meta-analysis (MBMA) can be utilized to synthesize literature data and predict drug efficacy, particularly suitable for constructing external comparator arms for non-randomized controlled trials (NRCTs). This study evaluated the...
A Multiple Imputation Workflow for Handling Missing Covariate Data in Pharmacometrics Modeling [0.03%]
处理药代动力学建模中缺失协变量数据的多重插补工作流程
My-Luong Vuong,Geert Verbeke,Erwin Dreesen
My-Luong Vuong
Covariate missingness is a prevalent issue in pharmacometrics modeling. Incorrect handling of missing covariates can lead to biased parameter estimates, adversely affecting clinical practice and drug development dosing decisions. Single imp...
Target-Mediated Drug Disposition (TMDD) Revisited: High Versus Low-Affinity Approximations of the TMDD Model [0.03%]
重温以靶点为介导的药物处置（TMDD）模型：高亲和力与低亲和力近似模型的对比分析
Ronny Straube
Ronny Straube
Target-mediated drug disposition (TMDD) is often associated with high-affinity binding to a target resulting in nonlinear pharmacokinetics. For large molecules, such as monoclonal antibodies, this can lead to increased clearance at sub-satu...