Acarofauna of Neotropical reptiles: Integrative morphology and vector competence of zoonotic pathogens [0.03%]
中南美洲爬行类动物的皮下寄生虫：综合形态和人畜共患病原体向导性
Jairo Alfonso Mendoza-Roldan,Marcos Antônio Bezerra-Santos,Darci Moraes Barros Battesti et al.
Jairo Alfonso Mendoza-Roldan et al.
The Neotropical region stands out as a megadiverse area in terms of herpetofauna, hosting more than 4457 species, 2233 of which are distributed across South America. Reptiles are recognized as amplifiers and reservoirs of several pathogens,...
Advances, challenges, and applications of laboratory culture of digenean trematode parasites [0.03%]
叠盘吸虫类生物的实验室培养进展、挑战及应用
Simão Correia,Sergio Fernández-Boo,Manuel Vera et al.
Simão Correia et al.
The development of parasite cultures has long been pivotal in advancing parasitology, with broad applications in medicine, veterinary science, and biology. Laboratory cultures are invaluable tools for studying parasite biology, host-parasit...
Anja Joachim,Anna Feix,Bärbel Ruttkowski et al.
Anja Joachim et al.
Cystoisospora suis, the cause of suckling piglet coccidiosis, is an intestinal protozoan pathogen of worldwide distribution and major economic and animal health significance in swine industry. It is closely related to cyst-forming, facultat...
Martin Horn,Lucia Bieliková,Andrea Vostoupalová et al.
Martin Horn et al.
Trematodes, a class of parasitic flatworms, are responsible for a variety of devastating diseases in humans and animals, with schistosomiasis and fascioliasis being prominent examples. Trematode proteolytic systems involved in the host-para...
Lawrence J Liu,Anthony J O&#x;Donoghue,Conor R Caffrey
Lawrence J Liu
The proteasome is a proteolytically active molecular machine comprising many different protein subunits. It is essential for growth and survival in eukaryotic cells and has long been considered a drug target. Here, we summarize the biology ...
Gunjan Arora,Jiří Černý
Gunjan Arora
Malaria remains a major health hazard for humans, despite the availability of efficacious antimalarial drugs and other interventions. Given that the disease is often deadly for children under 5 years and pregnant women living in malaria-end...
Proteases and protease inhibitors in saliva of hard ticks: Biological role and pharmacological potential [0.03%]
硬蜱唾液中的蛋白酶和蛋白酶抑制剂：生物学作用与药理学潜力
Jiří Černý,Gunjan Arora
Jiří Černý
Hard ticks (family Ixodidae) are significant vectors of pathogens affecting humans and animals. This review explores the composition of tick saliva, focusing on proteases and protease inhibitors, their biological roles, and their potential ...
Advances in protease inhibition-based chemotherapy: A decade of insights from Malaria research [0.03%]
基于蛋白酶抑制的化疗进展：来自疟疾研究的十年启示
Daniel Sojka,Pavla Šnebergerová
Daniel Sojka
Over the last decade, research on the most studied parasite, Plasmodium falciparum, has disclosed significant findings in protease research. Detailed descriptions of the individual roles of protease isoenzymes from various protease classes ...
Matthew S Moser,Elissa A Hallem
Matthew S Moser
Parasitic nematodes infect over 2 billion individuals worldwide, primarily in low-resource areas, and are responsible for several chronic and potentially deadly diseases. Throughout their life cycle, these parasites are thought to use astac...
Unveiling the peptidases of parasites from the office chair - The endothelin-converting enzyme case study [0.03%]
从办公室椅子上揭示寄生虫的肽酶——内皮素转换酶案例研究
Lukáš Konečný,Kristýna Peterková
Lukáš Konečný
The emergence of high-throughput methodologies such as next-generation sequencing and proteomics has necessitated significant advancements in biological databases and bioinformatic tools, therefore reshaping the landscape of research into p...