Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition [0.03%]
通过抑制骨硬化蛋白来治愈多发性骨髓瘤的溶骨病灶并恢复骨骼健康
Hayley M Sabol,Aric Anloague,Japneet Kaur et al.
Hayley M Sabol et al.
Background: Multiple myeloma (MM) is associated with a debilitating bone disease that poses significant therapeutic challenges. MM bone disease is characterized by increased bone resorption and suppression of osteoblasts,...
Elevated TIM3 expression on bone marrow T cells drives immune dysfunction in early relapsed blood cancer after allogeneic hematopoietic stem cell transplantation [0.03%]
移植物抗宿主病早期复发血液肿瘤患者骨髓T细胞上TIM3高表达导致免疫功能障碍
Thi Thuy Duong Pham,Su-Young Choi,Jeong Suk Koh et al.
Thi Thuy Duong Pham et al.
Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the leading cause of treatment failure in patients with hematologic malignancies. To better understand the mechanisms underlying early relapse (ER), we com...
CD47 antibody-armed oncolytic adenovirus promotes chimeric antigen receptor macrophage phagocytosis and antitumor immunity [0.03%]
抗CD47抗体武装的溶瘤腺病毒促进嵌合抗原受体巨噬细胞吞噬及抗肿瘤免疫反应
Zhongbing Qi,Shichuan Hu,Jing Zhao et al.
Zhongbing Qi et al.
Background: Chimeric antigen receptor (CAR)-T cell therapy has shown success in hematologic malignancies but has encountered challenges in solid tumors. Macrophages, being a potentially effective therapeutic target, have ...
In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy [0.03%]
深入探讨与三级淋巴器官结构相关并参与浸润肿瘤基质细胞及其在癌症免疫治疗中的潜在作用
Maedeh Radandish,Niloofar Mashhadi,Amir Hossein Aghayan et al.
Maedeh Radandish et al.
Background and purpose: The tumor microenvironment (TME) is widely acknowledged as a pivotal regulator of cancer progression. However, the dualistic role of tertiary lymphoid structures (TLSs), which serve as critical imm...
An ureido-substituted benzenesulfonamide carbonic anhydrase inhibitor exerts a potent antitumor effect in vitro and in vivo [0.03%]
一种脲取代苯磺酰胺类碳酸酐酶抑制剂对肿瘤具有体内和体外的强力抑制作用
Giorgia Gazzaroli,Camilla Tavani,Serena Filiberti et al.
Giorgia Gazzaroli et al.
Carbonic anhydrase IX (CA IX) is a tumor-specific metallo-enzyme upregulated during hypoxic conditions and implicated in several pathophysiological processes where tissue pH regulation is required such as cancer, cell invasion, metastatic a...
Incidence, mortality, and risk factors of bladder, kidney, prostate and testicular cancers in China and comparisons with the United States, the United Kingdom, Japan, and the Republic of Korea: an up-to-date overview based on the Global Burden of Disease 2021 [0.03%]
基于全球疾病负担研究2021的中国及美国、英国、日本和韩国尿路主要肿瘤发病、死亡及危险因素的最新概述比较研究：基于Global Burden of Disease 2021的研究综述式比较研究
Gaohaer Kadeerhan,Zhongji Jiang,Hong Guo et al.
Gaohaer Kadeerhan et al.
Background: The burden of genitourinary cancers has significantly changed in China over the recent decades. This study aims to identify the epidemiological trends and disparities in four common genitourinary cancers, incl...
Bisecting GlcNAc enhances CD8+ T cell-mediated killing of breast cancer by suppressing PD-L1 expression and its binding to PD-1 [0.03%]
岩藻糖转移酶双功能切割增强CD8+t细胞介导的乳腺癌杀伤作用：通过抑制PD-L1表达及其与PD-1结合实现
Xueting Ren,Jinpeng Wu,Jing Li et al.
Xueting Ren et al.
Background: The abundance of PD-L1 on the surface of tumor cells is a critical factor in sensitizing these cells to T cell-mediated immune killing. While abnormal glycosylation of PD-L1 is known to influence its expressio...
Yida Wang,Feng Zhang,Zhiwen Qian et al.
Yida Wang et al.
Collagen in the tumor microenvironment plays diverse biological roles, from serving as the structural framework of tumors to influencing immune responses, angiogenesis, and tumor progression. Consequently, developing strategies to optimize ...
Targeted degradation of sICOSL reverses cytotoxic T cells dysfunction [0.03%]
靶向降解sICOSL可逆转细胞毒性T细胞功能障碍
Zhenghao Wu,Peng Zheng,Ruobing Qi et al.
Zhenghao Wu et al.
Dysfunction of cytotoxic T cells (CTL) remains a major cause of tumor immune evasion and is correlated with poor cancer survival. Here, we found that increased soluble form of ICOSL (sICOSL) induced CTL dysfunction and was associated with s...
Decoding the metabolic dialogue in the tumor microenvironment: from immune suppression to precision cancer therapies [0.03%]
解码肿瘤微环境中的代谢对话：从免疫抑制到精准癌症治疗
Ruoli Wang,Jincheng Zhuang,Qi Zhang et al.
Ruoli Wang et al.
The tumor microenvironment (TME) represents a metabolic battleground where immune cells and cancer cells vie for essential nutrients, ultimately influencing antitumor immunity and treatment outcomes. Recent advancements have shed light on h...