In vitro and in vivo properties of CD133 expressing cells from human lung cancer cell lines [0.03%]
人肺癌细胞系中CD133阳性细胞的体外和体内特性
Ping Wang,Zhenhe Suo,Mengyu Wang et al.
Ping Wang et al.
Background: Tumor development is recently hypothesized to depend on a rare cell population with stem cell properties, such cells are called cancer stem cells (CSCs) or tumor-initiating cells (TICs). From various cancer ti...
Autoantibodies to tumor-associated antigens as biomarkers in human hepatocellular carcinoma (HCC) [0.03%]
自身免疫肿瘤相关抗原作为人类肝细胞癌（HCC）生物标志物的研究
Liping Dai,Ningjing Lei,Mei Liu et al.
Liping Dai et al.
Tumor-associated antigens (TAAs) recognized by cellular and/or humoral effectors of the immune system are attractive targets for diagnostic and therapeutic approaches to human cancer. Different approaches can be used to comprehensively char...
Donor Vδ1+ γδ T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL [0.03%]
供者Vδ1+γδT细胞在异基因造血干细胞移植后扩增，并且针对CMV感染细胞表现出反应性，但不具有对进展型B-CLL的反应性
Immo Prinz,Kristina Thamm,Matthias Port et al.
Immo Prinz et al.
γδ T lymphocytes play an important role in immune reactions towards infections and malignancies. In particular, Vγ9-Vδ1+ T lymphocytes are thought to play protective antiviral roles in human CMV infection. Recently, Vδ1+ T lymphocytes ...
Maria Carmo Pereira Nunes,Daniel Ribeiro Moreira,Teresa Cristina Abreu Ferrari
Maria Carmo Pereira Nunes
Cardiac metastasis of germ cell tumors is extremely rare, particularly in females. We report a case of a 26-year-old previously healthy woman who presented with a 5-month history of abdominal pain, weight loss, fever, generalized lymphadeno...
Three are better than one: plasminogen receptors as cancer theranostic targets [0.03%]
三个比一个好：纤溶酶原受体作为癌症诊疗靶点
Patrizia Ceruti,Moitza Principe,Michela Capello et al.
Patrizia Ceruti et al.
Activation of plasminogen on the cell surface initiates a cascade of protease activity with important implications for several physiological and pathological events. In particular, components of the plasminogen system participate in tumor g...
Vincristine could partly suppress stromal support to T-ALL blasts during pegylated arginase I treatment [0.03%]
长春新碱可以部分抑制血管细胞对T-ALL细胞的支持作用 Pegylated精氨酸酶I疗法期间出现
Fung Kwong-Lam,Chan Godfrey Chi-Fung
Fung Kwong-Lam
Background: Relapsed T-lineage acute lymphoblastic leukemia (T-ALL) has been an incurable disease. Recent reports showed that an L-arginine depleting enzyme, pegylated arginase (BCT-100) may be effective against T-ALL cel...
Increased expression of miR-221 is associated with shorter overall survival in T-cell acute lymphoid leukemia [0.03%]
T淋巴细胞急性淋巴细胞性白血病中miR-221表达增强与总生存期缩短有关
Hamilton L Gimenes-Teixeira,Antonio R Lucena-Araujo,Guilherme A Dos Santos et al.
Hamilton L Gimenes-Teixeira et al.
Background: CD56 expression has been associated with a poor prognosis in lymphoid neoplasms, including T-cell acute lymphoblastic leukemia (T-ALL). MicroRNAs (miRNAs) play an important role in lymphoid differentiation, an...
Bone marrow non-mesenchymal mononuclear cells induce functional differentiation of neuroblastoma cells [0.03%]
骨髓非间质单核细胞诱导神经母细胞瘤细胞的功能分化
Chareerut Phruksaniyom,Permphan Dharmasaroja,Surapol Issaragrisil
Chareerut Phruksaniyom
Less is known about the non-mesenchymal mononuclear cell fraction of human bone marrow on functional adaptation of neuroblastoma cells. Using immunocytochemistry, we showed that bone-marrow mononuclear cell (BMMC)-conditioned medium can ind...
Genetic profiles of plasmacytoid (BDCA-4 expressing) DC subtypes-clues to DC subtype function in vivo [0.03%]
浆细胞样树突状细胞亚型的基因表达特征及对体内DC功能的研究提示
Stephen H Wrzesinski,Jan L Fisher,Marc S Ernstoff
Stephen H Wrzesinski
Among the dendritic cell (DC) subsets, plasmacytoid DC's (pDC) are thought to be important in the generation of both antiviral and antitumor responses. While pDC may be useful in developing dendritic cell-based tumor vaccines, the low frequ...
A standardized microarray assay for the independent gene expression markers in AML: EVI1 and BAALC [0.03%]
急性髓系白血病独立基因表达标志EVI1和BAALC的微阵列检测方法
Jaap Brand,Martin H van Vliet,Leonie de Best et al.
Jaap Brand et al.
High levels of BAALC, ERG, EVI1 and MN1 expression have been associated with shorter overall survival in AML but standardized and clinically validated assays are lacking. We have therefore developed and optimized an assay for standardized d...