"T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach" [0.03%]
"T细胞前体淋巴瘤（T-PLL），两种病例和细胞遗传学重要作用的体现：一种多学科方法"
Carlos A Tirado,Phillip Starshak,Paul Delgado et al.
Carlos A Tirado et al.
T-cell prolymphocytic leukemia (T-PLL) is a rare form of leukemia composed of mature T-cells that usually presents in older people with a median age of 65. Most cases of T-PLL will harbor chromosomal abnormalities involving 14q11.2 (TCR alp...
Pediatric T-cell prolymphocytic leukemia with an isolated 12(p13) deletion and aberrant CD117 expression [0.03%]
孤立的12号染色体短臂1区3带缺失和异常CD117表达的儿童T细胞淋巴母细胞白血病/淋巴瘤
Michael Bellone,Annika M Svensson,Ann-Leslie Zaslav et al.
Michael Bellone et al.
T-cell Prolymphocytic leukemia (T-PLL) is a rare post-thymic T-cell malignancy that follows an aggressive clinical course. The classical presentation includes an elevated white blood cell (WBC) count with anemia and thrombocytopenia, hepato...
Immune modulation therapy in the management of bortezomib-induced peripheral neuropathy [0.03%]
免疫调节治疗硼替佐米诱发的外周神经病变管理中的作用
Ashley Jeter,Yubin Kang
Ashley Jeter
Peripheral neuropathy (PN) is one of the most common side effects of bortezomib therapy. The majority of bortezomib-related PN is a sensory neuropathy of mild to moderate degree, and is reversible after dose reduction or discontinuation. Ho...
Molecular monitoring of minimal residual disease in two patients with MLL-rearranged acute myeloid leukemia and haploidentical transplantation after relapse [0.03%]
异基因 haplo-HSCT 后两例MLL-重排急性髓系白血病微小残留病分子学监测
Thomas Burmeister,Mara Molkentin,Claus Meyer et al.
Thomas Burmeister et al.
This report describes the clinical courses of two acute myeloid leukemia patients. Both had MLL translocations, the first a t(10;11)(p11.2;q23) with MLL-AF10 and the second a t(11;19)(q23;p13.1) with MLL-ELL fusion. They achieved a clinical...
Oxidative stress and redox state-regulating enzymes have prognostic relevance in diffuse large B-cell lymphoma [0.03%]
氧化应激和红氧调节酶在弥漫性大B细胞淋巴瘤中的预后价值
Pekka Peroja,Anna Kaisa Pasanen,Kirsi-Maria Haapasaari et al.
Pekka Peroja et al.
Background: Oxidative stress and redox-regulating enzymes may have roles both in lymphomagenesis and resistance to lymphoma therapy. Previous studies from the pre-rituximab era suggest that antioxidant enzyme expression i...
Dazhong Xu,Qi Wang,Yongping Jiang et al.
Dazhong Xu et al.
Angiogenesis is essential for promoting growth and metastasis of solid tumors by ensuring blood supply to the tumor mass. Targeting angiogenesis is therefore an attractive approach to therapeutic intervention of cancer. Tumor angiogenesis i...
Hosam A Elbaz,Todd A Stueckle,William Tse et al.
Hosam A Elbaz et al.
A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenu...
Response of hemorrhagic bullous skin lesions of the breast secondary to primary systemic amyloidosis to a five-drug combination chemotherapy: a case report and review of the literature [0.03%]
原发性全身性淀粉样变性继发的乳房出血性大疱性皮肤损害对五联化疗的反应：病例报告及文献复习
Aref Agheli,Marvin Becker,Gary Becker et al.
Aref Agheli et al.
Two major types of amyloidosis are primary amyloidosis or amyloid light chain amyloidosis and secondary amyloidosis. Although amyloidosis involves a variety of organ systems including skin, the occurrence of bullous skin lesions is rare. Li...
CD19: a biomarker for B cell development, lymphoma diagnosis and therapy [0.03%]
CD19：B细胞发育、淋巴瘤诊断和治疗的生物标志物
Kemeng Wang,Guoqing Wei,Delong Liu
Kemeng Wang
The human CD19 antigen is a 95 kd transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD19 is classified as a type I transmembrane protein, with a single transmembrane domain, a cytoplasmic C-terminus, and extracellular ...
Clinical significance of E2F1 protein expression in non-small cell lung cancer [0.03%]
E2F1蛋白在非小细胞肺癌的表达及临床意义分析
Jung-Jyh Hung,Chung-Tsen Hsueh,Kuan-Hua Chen et al.
Jung-Jyh Hung et al.
Background: The transcription factor E2F1 has been implicated in cell cycle control and DNA damage response. Paradoxically, E2F1 can promote apoptosis and function as tumor suppressor. In non-small cell lung cancer (NSCLC...