Shachar Laks,Kevin A Brueske,Eddy C Hsueh
Shachar Laks
Neoadjuvant therapy is an under-utilized regimen for the treatment of metastatic melanoma. The use of this approach has been increasing in other tumor types. Neoadjuvant therapy may reduce occult circulating tumor cell burden in the face of...
The combined expression of the stromal markers fibronectin and SPARC improves the prediction of survival in diffuse large B-cell lymphoma [0.03%]
联合基质标志物纤维连接蛋白和SPARC的表达可改善弥漫性大B细胞淋巴瘤预后预测
Simone Brandt,Chiara Montagna,Antoin Georgis et al.
Simone Brandt et al.
Background: In diffuse large B-cell lymphomas, gene expression profiling studies attributed a major biologic role to non-neoplastic cells of the tumour microenvironment as its composition and characteristics were shown to...
Opticin, a small leucine-rich proteoglycan, is uniquely expressed and translocated to the nucleus of chronic lymphocytic leukemia cells [0.03%]
一种小的富含亮氨酸残基的蛋白糖类opticin在慢性淋巴细胞白血病细胞中特异表达并转位至细胞核内
Eva Mikaelsson,Anders Osterborg,Zahra Tahmasebi Fard et al.
Eva Mikaelsson et al.
Background: Opticin (OPTC) is a member of the small leucine-rich proteoglycan (SLRP) family and is localized particularly in certain extracellular matrices. We have previously reported the unique expression of another SLR...
Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells [0.03%]
异硫氰酸苯乙酯和紫杉醇在乳腺癌细胞中协同增强凋亡及α-微管蛋白过度乙酰化作用
Shundong Cang,Yuehua Ma,Jen-Wei Chiao et al.
Shundong Cang et al.
Combination of phenethyl isothiocyanate (PEITC) and paclitaxel (taxol) has been shown to work synergistically to increase apoptosis and cell cycle arrest in breast cancer cells. In this report, we further explored the mechanisms for the syn...
Aileen Novero,Pavan M Ravella,Yamei Chen et al.
Aileen Novero et al.
Research over the role of Bruton's agammaglobulinemia tyrosine kinase (BTK) in B-lymphocyte development, differentiation, signaling and survival has led to better understanding of the pathogenesis of B-cell malignancies. Down-regulation of ...
The effect of metronomic versus standard chemotherapy on the regulatory to effector T-cell equilibrium in cancer patients [0.03%]
/meta>代谢化疗与常规化疗对癌症患者调节性T细胞和效应T细胞平衡影响的比较(meta)
Anna Koumarianou,Maria-Ioanna Christodoulou,Pavlos Patapis et al.
Anna Koumarianou et al.
Background: The host's immune system is crucially involved in cancer development and progression. The ratio of regulatory to effector T-cells, as well as the interplay of T-cells with therapeutic agents, impact on cancer ...
Fei-Yu Niu,Yi-Long Wu
Fei-Yu Niu
Since the recognition of epidermal growth factor receptor (EGFR) as a therapeutic target, EGFR tyrosine kinase inhibitors (TKIs) have been used in lung cancer patients with EGFR mutations, which has been a major breakthrough for lung cancer...
Demographic, clinical, pathological, molecular, treatment characteristics and outcomes of nonmetastatic inflammatory breast cancer in Morocco: 2007 and 2008 [0.03%]
摩洛哥非转移性炎性乳腺癌的发病特征、临床病理学、分子、治疗及转归：2007年和2008年数据
Nabil Ismaili,Hind Elyaakoubi,Youssef Bensouda et al.
Nabil Ismaili et al.
We analyze the epidemiological characteristics and outcomes of 72 patients diagnosed with non-metastatic inflammatory breast cancer (IBC) at National Institute of Oncology of Rabat in Morocco, between January 2007 and December 2008. IBC pat...
Zihai Li,Lieping Chen,Mark P Rubinstein
Zihai Li
The immune system is the built-in host defense mechanism against infectious agents as well as cancer. Protective immunity against cancer was convincingly demonstrated in the 1940s with syngeneic animal models (JNCI 18:769-778, 1976; Cancer ...
Everolimus and sunitinib for advanced pancreatic neuroendocrine tumors: a matching-adjusted indirect comparison [0.03%]
依维莫司与舒尼替尼治疗晚期胰腺神经内分泌肿瘤的匹配调整间接比较研究
James Signorovitch,Elyse Swallow,Evan Kantor et al.
James Signorovitch et al.
Background: Everolimus and sunitinib have been approved for the treatment advanced pancreatic neuroendocrine tumors, but have not been compared to each other in a randomized trial and have not demonstrated prolonged overa...