Tinzaparin and other low-molecular-weight heparins: what is the evidence for differential dependence on renal clearance? [0.03%]
地那帕汀和其他低分子肝素：不同依赖肾清除的证据是什么？
Kristian B Johansen,Torben Balchen
Kristian B Johansen
Since low-molecular-weight heparins (LMWHs) are eliminated preferentially via the kidneys, the potential for accumulation of these agents (and an increased risk of bleeding) is of particular concern in populations with a high prevalence of ...
Optimization of cytarabine (ARA-C) therapy for acute myeloid leukemia [0.03%]
阿糖胞苷(ARA-C)治疗急性髓系白血病的优化策略研究进展
Richard L Momparler
Richard L Momparler
Cytarabine (cytosine arabinoside) is one of the most effective drugs for the treatment of acute myeloid leukemia. The standard dose of cytarabine used to treat this leukemia is 100 mg per square meter. In an attempt to improve the effective...
Clinicopathological analysis of primary adrenal diffuse large B-cell lymphoma: effectiveness of rituximab-containing chemotherapy including central nervous system prophylaxis [0.03%]
原发性肾上腺弥漫大B细胞淋巴瘤的临床病理分析及包括中枢神经系统预防在内的含利妥昔单抗化疗的有效性
Satoshi Ichikawa,Noriko Fukuhara,Ai Inoue et al.
Satoshi Ichikawa et al.
Background: Primary adrenal lymphoma (PAL) is an extremely rare subtype of extranodal non-Hodgkin's lymphoma. Some researchers have reported some of the characteristics of PAL and its association with poor prognosis; howe...
Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells [0.03%]
氧硫胺素通过抑制转酮酶改变胰腺癌细胞中的蛋白质信号动力学
Jiarui Wang,Xuemei Zhang,Danjun Ma et al.
Jiarui Wang et al.
Oxythiamine (OT), an analogue of anti-metabolite, can suppress the nonoxidative synthesis of ribose and induce cell apoptosis by causing a G1 phase arrest in vitro and in vivo. However, the molecular mechanism remains unclear yet. In the pr...
Zhong Li
Zhong Li
Cancer stem cells (CSCs) or tumor initiating cells (TICs) contribute to tumorigenesis, metastasis, recurrence and chemoresistance. CD133, a pentaspan membrane glycoprotein, has been used as a stem cell biomarker for isolation of stem-like c...
In vitro and in vivo properties of CD133 expressing cells from human lung cancer cell lines [0.03%]
人肺癌细胞系中CD133阳性细胞的体外和体内特性
Ping Wang,Zhenhe Suo,Mengyu Wang et al.
Ping Wang et al.
Background: Tumor development is recently hypothesized to depend on a rare cell population with stem cell properties, such cells are called cancer stem cells (CSCs) or tumor-initiating cells (TICs). From various cancer ti...
Autoantibodies to tumor-associated antigens as biomarkers in human hepatocellular carcinoma (HCC) [0.03%]
自身免疫肿瘤相关抗原作为人类肝细胞癌（HCC）生物标志物的研究
Liping Dai,Ningjing Lei,Mei Liu et al.
Liping Dai et al.
Tumor-associated antigens (TAAs) recognized by cellular and/or humoral effectors of the immune system are attractive targets for diagnostic and therapeutic approaches to human cancer. Different approaches can be used to comprehensively char...
Donor Vδ1+ γδ T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL [0.03%]
供者Vδ1+γδT细胞在异基因造血干细胞移植后扩增，并且针对CMV感染细胞表现出反应性，但不具有对进展型B-CLL的反应性
Immo Prinz,Kristina Thamm,Matthias Port et al.
Immo Prinz et al.
γδ T lymphocytes play an important role in immune reactions towards infections and malignancies. In particular, Vγ9-Vδ1+ T lymphocytes are thought to play protective antiviral roles in human CMV infection. Recently, Vδ1+ T lymphocytes ...
Maria Carmo Pereira Nunes,Daniel Ribeiro Moreira,Teresa Cristina Abreu Ferrari
Maria Carmo Pereira Nunes
Cardiac metastasis of germ cell tumors is extremely rare, particularly in females. We report a case of a 26-year-old previously healthy woman who presented with a 5-month history of abdominal pain, weight loss, fever, generalized lymphadeno...
Three are better than one: plasminogen receptors as cancer theranostic targets [0.03%]
三个比一个好：纤溶酶原受体作为癌症诊疗靶点
Patrizia Ceruti,Moitza Principe,Michela Capello et al.
Patrizia Ceruti et al.
Activation of plasminogen on the cell surface initiates a cascade of protease activity with important implications for several physiological and pathological events. In particular, components of the plasminogen system participate in tumor g...