Activation of Akt at T308 and S473 in alcohol, tobacco and HPV-induced HNSCC: is there evidence to support a prognostic or diagnostic role? [0.03%]
Akt在酒精、烟草和HPV引起的HNSCC中T308和S473的激活：是否有证据支持其预后或诊断作用？
Mohammad R Islam,Ian R Ellis,Michaelina Macluskey et al.
Mohammad R Islam et al.
Background: Tobacco, alcohol and HPV infection are associated with increased risk of HNSCC. However, little is known about the underlying signaling events influencing risk. We aimed to investigate the relationship between...
Radium-223 dichloride bone-targeted alpha particle therapy for hormone-refractory breast cancer metastatic to bone [0.03%]
氯化镭-223骨靶向α粒子治疗对骨转移的激素难治性乳腺癌
Amol Takalkar,Scott Adams,Vivek Subbiah
Amol Takalkar
Background: Hormone-refractory breast cancer metastatic to bone is a clinically challenging disease associated with high morbidity, poor prognosis, and impaired quality of life owing to pain and skeletal-related events. I...
Epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort [0.03%]
多族裔城市居民骨髓增生异常综合征的流行病学研究
Ashwin Sridharan,Rishi Jain,Marcus A Bachhuber et al.
Ashwin Sridharan et al.
Little is known about the epidemiology of MDS in minority populations. The IPSS and newly released IPSS-R are important clinical tools in prognostication of patients with MDS. Therefore, we conducted a retrospective epidemiological analysis...
Acquired hemophilia A and von Willebrand syndrome in a patient with late-onset systemic lupus erythematosus [0.03%]
一位迟发性系统性红斑狼疮患者获得性血友病A和血管性假血症综合征的病例报告
Christina Dicke,Katharina Holstein,Sonja Schneppenheim et al.
Christina Dicke et al.
Acquired hemophilia A (AHA) and acquired von Willebrand Syndrome (AVWS) are both rare bleeding disorders that can be associated with lymphoproliferative or autoimmune diseases. AHA is uniformly caused by inhibitory autoantibodies against co...
Neuroblastoma of the elderly, an oncologist's nightmare: case presentation, literature review and SEER database analysis [0.03%]
老年人神经母细胞瘤：一个肿瘤科医生的噩梦——病例报告、文献综述和SEER数据库分析
Elisa Rogowitz,Hani M Babiker,Mohammed Kanaan et al.
Elisa Rogowitz et al.
Neuroblastoma is considered a pediatric malignancy as over 95% of cases are diagnosed in patients ≤10 years old. This cancer is extremely rare in elderly patients. We conducted a Surveillance, Epidemiology, and End Results (SEER) database ...
Modelling of a genetically diverse evolution of Systemic Mastocytosis with Chronic Myelomonocytic Leukemia (SM-CMML) by Next Generation Sequencing [0.03%]
基于下一代测序技术的系统性肥大细胞增生症与慢性粒单胞细胞白血病(SM-CMML)遗传多样性进化的建模研究
Markus Rechsteiner,Rouven Müller,Tanja Reineke et al.
Markus Rechsteiner et al.
Background: Systemic mastocytosis (SM) is a heterogenous, clonal mast cell (MC) proliferation, rarely associated with clonal hematologic non-mast cell lineage disease (SM-AHNMD). KIT (D816V) is regarded as driver-mutation...
Altered expression pattern of miR-29a, miR-29b and the target genes in myeloid leukemia [0.03%]
微小核糖核酸-29a、微小核糖核酸-29b及其靶基因在髓系白血病中异常表达模式的研究
Ling Xu,Yan Xu,Zhenyi Jing et al.
Ling Xu et al.
Objectives: The miR-29 family have been demonstrated acting as vital tumor suppressor in multiple cancers as well as regulators in the adaptive immune system. Little is known about their role in leukemogenesis. The purpos...
Jennifer S Woo,Michael O Alberti,Carlos A Tirado
Jennifer S Woo
In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent childhood hematological malignancy, as well as the leading cause of childhood cancer-related mortality. Advances in cytogenetics utilizing array-based...
Salvage therapy with high dose Intravenous Immunoglobulins in acquired Von Willebrand Syndrome and unresponsive severe intestinal bleeding [0.03%]
高剂量静脉注射免疫球蛋白治疗获得性血管性假血友病伴严重肠出血患者的一项补救疗法研究
Massimo Cugno,Alberto Tedeschi,Simona Maria Siboni et al.
Massimo Cugno et al.
A 91-year-old woman affected with acquired Von Willebrand (VW) syndrome and intestinal angiodysplasias presented with severe gastrointestinal bleeding (hemoglobin 5 g/dl). Despite replacement therapy with VW factor/factor VIII concentrate q...
Circulating MicroRNAs in gynecological malignancies: from detection to prediction [0.03%]
妇科恶性肿瘤中的循环miRNA：从检测到预测
Ya-Nan Zhao,Guan-Sheng Chen,Shun-Jia Hong
Ya-Nan Zhao
MicroRNAs (miRNAs) have been demonstrated to play critical roles in many physiological and pathophysiological processes. The presence of altered miRNA profiles in human body fluids has been reported for a number of diseases including gyneco...