CDKN1A and FANCD2 are potential oncotargets in Burkitt lymphoma and multiple myeloma [0.03%]
CDKN1A和FANCD2是Burkitt淋巴瘤和多发性骨髓瘤中的潜在致癌靶点
Seong-Su Han,Van S Tompkins,Dong-Ju Son et al.
Seong-Su Han et al.
Background: Comparative genetic and biological studies on malignant tumor counterparts in human beings and laboratory mice may be powerful gene discovery tools for blood cancers, including neoplasms of mature B-lymphocyte...
Long-term survival in a patient with progressive multifocal leukoencephalopathy after therapy with rituximab, fludarabine and cyclophosphamide for chronic lymphocytic leukemia [0.03%]
利妥昔单抗、氟达拉滨和环磷酰胺治疗慢性淋巴细胞性白血病后，伴发进行性多灶性白质脑病的患者长期生存状况良好
Heidys Garrote,Adolfo de la Fuente,Raquel Oña et al.
Heidys Garrote et al.
A 50-year-old male with chronic lymphocytic leukemia (CLL) was treated with fludarabine, cyclophosphamide and rituximab, which produced a complete remission. Eight months after the last dose of rituximab he had visual disturbance, diminishe...
Antoine Dewitte,Annabelle Tanga,Julien Villeneuve et al.
Antoine Dewitte et al.
The role of platelets extends beyond hemostasis. The pivotal role of platelets in inflammation has shed new light on the natural history of conditions associated with acute or chronic inflammation. Beyond the preservation of vascular integr...
Selective inhibitors of nuclear export (SINE) in hematological malignancies [0.03%]
选择性核输出抑制剂在血液系统恶性肿瘤中的应用
Arundhati Das,Guoqing Wei,Kaushal Parikh et al.
Arundhati Das et al.
Regulated nucleo-cytoplasmic transport plays a major role in maintaining cellular homeostasis. CRM1 (chromosome region maintenance 1 or exportin 1 or XPO 1) is responsible for the nucleo-cytoplasmic transport of more than 200 proteins, incl...
Successful treatment of a Caucasian case of multifocal Castleman's disease with TAFRO syndrome with a pathophysiology targeted therapy - a case report [0.03%]
一例TAFRO综合征型Castleman病成功治疗的病例报告
Silvia Tedesco,Laura Postacchini,Lucia Manfredi et al.
Silvia Tedesco et al.
Background: Castleman-Kojima disease (TAFRO Syndrome) is characterized by Thrombocytopenia, Anasarca, myeloFibrosis, Renal dysfunction, Organomegaly, multiple lymphadenopathy and histopathology pattern of atypical Castlem...
Breast adenocarcinoma recurring as small cell carcinoma in a patient with a germline BRCA2 mutation: clonal evolution unchecked [0.03%]
BRCA2基因突变患者乳腺腺癌以小细胞癌形式复发：克隆演进未被遏制
Polly Niravath,Tanya Eble,Alejandro Contreras et al.
Polly Niravath et al.
Background: Because up to 30% of breast cancer cases may relapse, understanding the biology of recurrent breast cancer is imperative in preventing these poor outcomes. Thus, we present this unusual case of a BRCA2 carrier...
Comparative study of the effect of rivaroxaban and fondaparinux on monocyte's coagulant activity and cytokine release [0.03%]
利伐沙班和磺达肝癸钠对单核细胞促凝活性及细胞因子释放的影响比较研究
Marc Laurent,Ulrich Joimel,Rémi Varin et al.
Marc Laurent et al.
Objectives: Tissue factor (TF) exposed on activated monocytes and macrophages is involved in thrombosis through activation of factor X and cytokine release, responsible for inflammation and thrombosis. We investigated the...
Silence of MCL-1 upstream signaling by shRNA abrogates multiple myeloma growth [0.03%]
MCL-1上游信号的沉默可抑制多发性骨髓瘤生长
Mengchang Wang,Di Wu,Pengbo Liu et al.
Mengchang Wang et al.
Objectives: Multiple myeloma (MM) is an incurable B-cell cancer with accumulated clonal abnormal plasma cells in bone marrow of patients. MCL-1 (myeloid cell leukemia sequence 1) protein is an anti-apoptotic molecule in M...
Activity of dalotuzumab, a selective anti-IGF1R antibody, in combination with erlotinib in unselected patients with Non-small-cell lung cancer: a phase I/II randomized trial [0.03%]
Dalotuzumab（一种选择性胰岛素样生长因子1型受体抗体）联合厄洛替尼治疗非小细胞肺癌的Ⅰ/Ⅱ期随机临床试验
Teresa Moran,Enriqueta Felip,Vicki Keedy et al.
Teresa Moran et al.
Background: We investigated the safety and antitumor activity of dalotuzumab, a selective anti-insulin growth factor 1 receptor monoclonal antibody (IGF1R MoAb), plus erlotinib in a sequential phase I/II trial in unselect...
Targeting cholesterol synthesis increases chemoimmuno-sensitivity in chronic lymphocytic leukemia cells [0.03%]
靶向胆固醇合成可增加慢性淋巴细胞白血病细胞的化疗和免疫治疗敏感性
Indira Benakanakere,Tyler Johnson,Richard Sleightholm et al.
Indira Benakanakere et al.
Background: Cholesterol plays an important role in cancer development, drug resistance and chemoimmuno-sensitivity. Statins, cholesterol lowering drugs, can induce apoptosis, but also negatively interfere with CD-20 and r...