Immunosuppressive mechanisms of human bone marrow derived mesenchymal stromal cells in BALB/c host graft versus host disease murine models [0.03%]
人骨髓间充质 Stromal细胞在BALB/c宿主移植物抗宿主病小鼠模型中的免疫抑制机制
Joseph Delano Robles,Yin Ping Liu,Jiamin Cao et al.
Joseph Delano Robles et al.
Background: Mesenchymal stromal cells (MSCs) are proven to have immunosuppressive functions via various mechanisms. These mechanisms were demonstrated by administering bone marrow derived human MSCs (hMSCs) to graft versu...
Pharmacologically relevant doses of valproate upregulate CD20 expression in three diffuse large B-cell lymphoma patients in vivo [0.03%]
戊酸盐药理相关剂量上调三位弥漫大B细胞淋巴瘤患者CD20表达量的体内研究
Jesper Kofoed Damm,Sandra Gordon,Mats Ehinger et al.
Jesper Kofoed Damm et al.
Background: Epigenetic code modifications by histone deacetylase inhibitors (HDACi) have been proposed as potential new therapies for lymphoid malignancies. Diffuse large B-cell lymphoma (DLBCL) is the most common type of...
Effective long-term treatment with bevacizumab for relapsed glioblastoma: case report and review of the literature [0.03%]
贝伐单抗对复发性胶质母细胞瘤有效长期治疗的病例报告和文献回顾
Katrin Schweneker,Christoph Clemm,Melanie Brügel et al.
Katrin Schweneker et al.
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults. Despite the use of optimized first-line therapy, GBM is still associated with a poor prognosis and an effective second-line therapy remains an importa...
Do novo del(9)(p13) in a childhood T-cell prolymphocytic leukemia as sole abnormality [0.03%]
儿童T细胞大颗粒淋巴细胞白血病中del（9）（p13）异常独立出现一例报告
Abdulsamad Wafa,Abdulmunim Aljapawe,Moneeb Ak Othman et al.
Abdulsamad Wafa et al.
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive subtype of chronic lymphocytic leukemia. Usually it presents in older people with a median age of 61 years. T-PLL is characterized by elevated white blood cell (WBC) count with...
Effect of prognostic classification on temsirolimus efficacy and safety in patients with relapsed or refractory mantle cell lymphoma: a retrospective analysis [0.03%]
预后分类对复发或难治型套细胞淋巴瘤患者使用替西罗莫司疗效和安全性的影晌：一项回顾性分析
Georg Hess,Bertrand Coiffier,Michael Crump et al.
Georg Hess et al.
Background: Temsirolimus, a selective inhibitor of the mammalian target of rapamycin, has demonstrated clinical benefit versus investigator's choice (INV) of therapy in patients with relapsed/refractory mantle cell lympho...
Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin's lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1-phosphate receptors and integrins [0.03%]
免疫组化分析表明，B细胞非霍奇金淋巴瘤的解剖位置由差异表达的趋化因子受体、鞘氨醇-1-磷酸受体和整合素决定
Stephen Middle,Sarah E Coupland,Azzam Taktak et al.
Stephen Middle et al.
Background: The aim of this study was to elucidate the mechanisms responsible for the location of B-cell non-Hodgkin's lymphoma (B-NHL) at different anatomical sites. We speculated that the malignant B cells in these diso...
The effect of caffeine on cisplatin-induced apoptosis of lung cancer cells [0.03%]
咖啡因对顺铂诱导的肺癌细胞凋亡的影响
Gan Wang,Vanitha Bhoopalan,David Wang et al.
Gan Wang et al.
Background: Cisplatin is an important DNA-damaging anticancer drug that has been used to treat many cancer types. However, the effectiveness of cisplatin treatment diminishes quickly as cancer cells develop resistance to ...
Distinct genetic alterations in small cell carcinoma from different anatomic sites [0.03%]
不同解剖部位的小细胞癌具有不同的基因改变
Xiaoyong Zheng,Delong Liu,John T Fallon et al.
Xiaoyong Zheng et al.
Small cell carcinoma (SmCC) is a distinct clinicopathological entity first described in the lung. It represents approximately 15% of all bronchogenic carcinoma. Extrapulmonary small cell carcinoma (EPSmCC) morphologically indistinguishable ...
Modulation of deoxycytidine kinase (dCK) and glycogen synthase kinase (GSK-3β) by anti-CD20 (rituximab) and 2-chlorodeoxyadenosine (2-CdA) in human lymphoid malignancies [0.03%]
抗CD20（利妥昔单抗）和2氯脱氧腺苷（2-CdA）对人淋巴系统恶性肿瘤中脱氧胞苷激酶(dCK)和糖原合成酶激酶(GSK-3β)的调节作用
Ayad M Al-Katib,Amro Aboukameel,AbdulShukkur Ebrahim et al.
Ayad M Al-Katib et al.
Background: The combination of rituximab and 2-CdA is an effective therapy for B-cell tumors. However, the molecular mechanisms and enzymatic pathways involved in the interaction between the two agents are not fully under...
Lactate, a putative survival factor for myeloma cells, is incorporated by myeloma cells through monocarboxylate transporters 1 [0.03%]
单羧酸转运蛋白1介导的乳酸摄取是骨髓瘤细胞拟存活因子乳酸的作用基础
Shiho Fujiwara,Naoko Wada,Yawara Kawano et al.
Shiho Fujiwara et al.
Background: Lactate levels within tumors are correlated with metastases, tumor recurrence, and radioresistance, thus apparently contributing to poor outcomes in patients with various cancers. We previously reported that h...