Acute myeloid leukemia with t(7;21)(p22;q22) and 5q deletion: a case report and literature review [0.03%]
涉及t(7;21)(p22;q22)和5q-的急性髓系白血病一例报告及文献复习
Jianling Ji,Eric Loo,Sheeja Pullarkat et al.
Jianling Ji et al.
The gene RUNX1 at chromosome 21q22 encodes the alpha subunit of Core binding factor (CBF), a heterodimeric transcription factor involved in the development of normal hematopoiesis. Translocations of RUNX1 are seen in several types of leukem...
Lymphocytes from chronic lymphocytic leukaemia undergo ABL1-linked amoeboid motility and homotypic interaction as an early adaptive change to ex vivo culture [0.03%]
慢性淋巴细胞白血病淋巴细胞在体外培养早期发生ABL1介导的变形运动和同型相互作用适应性变化
Claire V Hutchinson,Shiva Natarajan,Suzanne M Johnson et al.
Claire V Hutchinson et al.
Background: Those stimuli that together promote the survival, differentiation and proliferation of the abnormal B-lymphocytes of chronic lymphocytic leukaemia (CLL) are encountered within tissues, where together they form...
A case of minor BCR-ABL1 positive acute lymphoblastic leukemia following essential thrombocythemia and originating from a clone distinct from that harboring the JAK2-V617F mutation [0.03%]
一例起源于携带JAK2-V617F突变克隆之外的克隆的原发性骨髓增生性肿瘤相关急性淋巴细胞白血病的病例报告
Yuya Nagai,Masahiro Kawahara,Noriko Sugino et al.
Yuya Nagai et al.
Here we report on a case of Philadelphia chromosome positive B lymphoblastic leukemia (Ph+ALL), which developed following a long duration of essential thrombocythemia (ET). A mutational analysis of Janus Kinase 2 (JAK2) revealed that the V6...
Tumor dormancy: potential therapeutic target in tumor recurrence and metastasis prevention [0.03%]
肿瘤休眠：预防肿瘤复发和转移的潜在治疗靶点
Sih-Han Wang,Shiaw-Yih Lin
Sih-Han Wang
In past decades, cancer patient survival has been improved with earlier detection and advancements in therapy. However, many patients who exhibit no clinical symptoms after frontline therapy subsequently suffer, often many years later, aggr...
Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies [0.03%]
代谢性乳腺癌的临床病理特征、预后因素和系统治疗策略
Theresa L Schwartz,Harveshp Mogal,Christos Papageorgiou et al.
Theresa L Schwartz et al.
Metaplastic breast cancer (MBC) is a rare subtype of invasive breast cancer that tends to have an aggressive clinical presentation as well as a variety of distinct histologic designations. Few systemic treatment options are available for MB...
Shachar Laks,Kevin A Brueske,Eddy C Hsueh
Shachar Laks
Neoadjuvant therapy is an under-utilized regimen for the treatment of metastatic melanoma. The use of this approach has been increasing in other tumor types. Neoadjuvant therapy may reduce occult circulating tumor cell burden in the face of...
The combined expression of the stromal markers fibronectin and SPARC improves the prediction of survival in diffuse large B-cell lymphoma [0.03%]
联合基质标志物纤维连接蛋白和SPARC的表达可改善弥漫性大B细胞淋巴瘤预后预测
Simone Brandt,Chiara Montagna,Antoin Georgis et al.
Simone Brandt et al.
Background: In diffuse large B-cell lymphomas, gene expression profiling studies attributed a major biologic role to non-neoplastic cells of the tumour microenvironment as its composition and characteristics were shown to...
Opticin, a small leucine-rich proteoglycan, is uniquely expressed and translocated to the nucleus of chronic lymphocytic leukemia cells [0.03%]
一种小的富含亮氨酸残基的蛋白糖类opticin在慢性淋巴细胞白血病细胞中特异表达并转位至细胞核内
Eva Mikaelsson,Anders Osterborg,Zahra Tahmasebi Fard et al.
Eva Mikaelsson et al.
Background: Opticin (OPTC) is a member of the small leucine-rich proteoglycan (SLRP) family and is localized particularly in certain extracellular matrices. We have previously reported the unique expression of another SLR...
Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells [0.03%]
异硫氰酸苯乙酯和紫杉醇在乳腺癌细胞中协同增强凋亡及α-微管蛋白过度乙酰化作用
Shundong Cang,Yuehua Ma,Jen-Wei Chiao et al.
Shundong Cang et al.
Combination of phenethyl isothiocyanate (PEITC) and paclitaxel (taxol) has been shown to work synergistically to increase apoptosis and cell cycle arrest in breast cancer cells. In this report, we further explored the mechanisms for the syn...
Aileen Novero,Pavan M Ravella,Yamei Chen et al.
Aileen Novero et al.
Research over the role of Bruton's agammaglobulinemia tyrosine kinase (BTK) in B-lymphocyte development, differentiation, signaling and survival has led to better understanding of the pathogenesis of B-cell malignancies. Down-regulation of ...