Modelling of a genetically diverse evolution of Systemic Mastocytosis with Chronic Myelomonocytic Leukemia (SM-CMML) by Next Generation Sequencing [0.03%]
基于下一代测序技术的系统性肥大细胞增生症与慢性粒单胞细胞白血病(SM-CMML)遗传多样性进化的建模研究
Markus Rechsteiner,Rouven Müller,Tanja Reineke et al.
Markus Rechsteiner et al.
Background: Systemic mastocytosis (SM) is a heterogenous, clonal mast cell (MC) proliferation, rarely associated with clonal hematologic non-mast cell lineage disease (SM-AHNMD). KIT (D816V) is regarded as driver-mutation...
Altered expression pattern of miR-29a, miR-29b and the target genes in myeloid leukemia [0.03%]
微小核糖核酸-29a、微小核糖核酸-29b及其靶基因在髓系白血病中异常表达模式的研究
Ling Xu,Yan Xu,Zhenyi Jing et al.
Ling Xu et al.
Objectives: The miR-29 family have been demonstrated acting as vital tumor suppressor in multiple cancers as well as regulators in the adaptive immune system. Little is known about their role in leukemogenesis. The purpos...
Jennifer S Woo,Michael O Alberti,Carlos A Tirado
Jennifer S Woo
In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent childhood hematological malignancy, as well as the leading cause of childhood cancer-related mortality. Advances in cytogenetics utilizing array-based...
Salvage therapy with high dose Intravenous Immunoglobulins in acquired Von Willebrand Syndrome and unresponsive severe intestinal bleeding [0.03%]
高剂量静脉注射免疫球蛋白治疗获得性血管性假血友病伴严重肠出血患者的一项补救疗法研究
Massimo Cugno,Alberto Tedeschi,Simona Maria Siboni et al.
Massimo Cugno et al.
A 91-year-old woman affected with acquired Von Willebrand (VW) syndrome and intestinal angiodysplasias presented with severe gastrointestinal bleeding (hemoglobin 5 g/dl). Despite replacement therapy with VW factor/factor VIII concentrate q...
Circulating MicroRNAs in gynecological malignancies: from detection to prediction [0.03%]
妇科恶性肿瘤中的循环miRNA：从检测到预测
Ya-Nan Zhao,Guan-Sheng Chen,Shun-Jia Hong
Ya-Nan Zhao
MicroRNAs (miRNAs) have been demonstrated to play critical roles in many physiological and pathophysiological processes. The presence of altered miRNA profiles in human body fluids has been reported for a number of diseases including gyneco...
Bryony Leeke,Judith Marsman,Justin M O&#x;Sullivan et al.
Bryony Leeke et al.
Recently, whole genome sequencing approaches have pinpointed mutations in genes that were previously not associated with cancer. For Acute Myeloid Leukaemia (AML), and other myeloid disorders, these approaches revealed a high prevalence of ...
Expression and diagnostic values of calretinin and CK5/6 in cholangiocarcinoma [0.03%]
钙结合蛋白和CK5/6在胆管癌的表达及诊断价值评估
Lanjing Zhang,Renee Frank,Emma E Furth et al.
Lanjing Zhang et al.
Background: Mesothelin, a mesothelial marker, has been found expressed in and as a potential treatment target of cholangioacarcinoma (CC). It is possible that CC may be derived from the cells sharing mesothelial markers. ...
Single low-dose rHuIL-12 safely triggers multilineage hematopoietic and immune-mediated effects [0.03%]
单剂量rHuIL-12安全诱导多谱系造血作用和免疫介导的作用
Mamata S Gokhale,Vladimir Vainstein,Jamie Tom et al.
Mamata S Gokhale et al.
Background: Recombinant human interleukin 12 (rHuIL-12) regulates hematopoiesis and cell-mediated immunity. Based on these hematopoietic and immunomodulatory activities, a recombinant human IL-12 (rHuIL-12) is now under d...
Survival and hospitalization among patients with acute myeloid leukemia treated with azacitidine or decitabine in a large managed care population: a real-world, retrospective, claims-based, comparative analysis [0.03%]
在大型管理式护理人群中使用阿扎胞苷或地西他滨治疗的急性髓系白血病患者的生存率和住院情况：基于理赔数据的回顾性、对比分析
B Douglas Smith,Charles L Beach,Dalia Mahmoud et al.
B Douglas Smith et al.
Background: This study examined patient outcomes using real world data for acute myeloid leukemia (AML) patients initiating treatment. Methods: ...
Vitamin D3 potentiates the antitumorigenic effects of arsenic trioxide in human leukemia (HL-60) cells [0.03%]
维生素D3能够增强三氧化二砷在人类白血病(HL-60)细胞中的抑癌功效
Christian S Rogers,Clement G Yedjou,Dwayne J Sutton et al.
Christian S Rogers et al.
Background: Arsenic trioxide (ATO) is a novel form of therapy that has been found to aid acute promyelocytic leukemia (APL) patients. Our laboratory has demonstrated that ATO-induced cytotoxicity in human leukemia (HL-60)...