Hypomagnesemia in lymphoma patients receiving CAR T therapy correlates with immune dysfunction and decreased survival [0.03%]
CAR-T治疗的淋巴瘤患者的低镁血症与免疫功能障碍和生存率下降相关
Jennifer J Gile,Patrizia Mondello,Zixing Wang et al.
Jennifer J Gile et al.
Background: Hypomagnesemia has been correlated with inferior outcomes in patients with large B cell lymphoma (LBCL) undergoing stem cell transplants. As T-cell and myeloid cell dysfunction have been associated with low ma...
Engineered nanoparticles for imaging and targeted drug delivery in hepatocellular carcinoma [0.03%]
肝细胞癌的成像和靶向给药用工程纳米粒子
Xianzhe Yu,Qin Zhang,Leibo Wang et al.
Xianzhe Yu et al.
Liver cancer, notably hepatocellular carcinoma (HCC), poses a significant global health burden due to its high fatality rates. Conventional antitumor medications face challenges, including poor targeting, high toxicity, and drug resistance,...
Hypomethylating agents plus venetoclax for high-risk MDS and CMML as bridge therapy to transplant: a GESMD study [0.03%]
低甲基化药物联合维奈克拉作为高危MDS和CMML移植前的桥接治疗：GESMD研究
Ines Zugasti,Monica Lopez-Guerra,Sandra Castaño-Díez et al.
Ines Zugasti et al.
Background: High-risk myelodysplastic syndromes (HR-MDS) and chronic myelomonocytic leukemia (CMML) remain therapeutic challenges with suboptimal outcomes. The only potentially curative treatment is allogeneic stem cell t...
Sarcosine sensitizes lung adenocarcinoma to chemotherapy by dual activation of ferroptosis via PDK4/PDHA1 signaling and NMDAR-mediated iron export [0.03%]
甜菜碱通过PDK4/PDHA1信号和NMDAR介导的铁输出双重激活铁死亡从而增强非小细胞肺癌化疗敏感性
Guangyao Shan,Yunyi Bian,Shencheng Ren et al.
Guangyao Shan et al.
Background: Ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation, is associated with chemoresistance in lung adenocarcinoma (LUAD). This study aims to investigate the role of sarcosine in ferrop...
Anti-angiogenic tyrosine kinase inhibitors and the pathophysiology of their toxic effects: revisiting the treatment of anemia in metastatic cancers [0.03%]
血管生成抑制酪氨酸激酶抑制剂及其毒性作用的病理生理学：重新审视转移性癌症贫血治疗
Tai Van Nguyen,Eurydice Angeli,Diaddin Hamdan et al.
Tai Van Nguyen et al.
Background: Anti-angiogenic tyrosine kinase inhibitors (TKIs) have become major drugs for the treatment of various cancer types, but with an overall high incidence of severe toxicities, particularly haematological toxicit...
Breakthroughs of CAR T-cell therapy in acute myeloid leukemia: updates from ASH 2024 [0.03%]
CAR-T细胞疗法在急性髓系白血病中的突破进展：来自2024年ASH会议的更新
Haixiao Zhang,Hong-Hu Zhu
Haixiao Zhang
While chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape for lymphoid malignancies, its greatest challenge remains in the treatment of acute myeloid leukemia (AML). Its success in AML has been limited ...
Validation of a microRNA profile in urine liquid biopsy with diagnostic and stratification value for bladder cancer classification, available through the open app BladdermiRaCan [0.03%]
通过开源应用程序BladdermiRaCan进行膀胱癌分类的尿液液体活检中microRNA谱系验证及其诊断和分层价值评估
Julia Oto,Raquel Herranz,Emma Plana et al.
Julia Oto et al.
We aimed to identify a profile of urine microRNAs (miRNAs) with diagnostic and stratification potential in the whole range of bladder cancer (BC) categories, to avoid current invasive, harmful and expensive procedures. We collected a first ...
Correction: AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition [0.03%]
纠正：AOH1996通过线粒体PCNA抑制作用靶向白血病干细胞的线粒体动力学和代谢
HyunJun Kang,Melissa Valerio,Jia Feng et al.
HyunJun Kang et al.
Published Erratum
Experimental hematology & oncology. 2025 Apr 10;14(1):56. DOI:10.1186/s40164-025-00650-7 2025
Pan Gao,Yang Zhang,Jun Ma et al.
Pan Gao et al.
Chronic lymphocytic leukemia (CLL) is characterized as a clonal proliferation of mature B lymphocytes with distinct immunophenotypic traits, predominantly affecting the middle-aged and elderly population. This condition is marked by an accu...
GLS2 inhibition synergizes with copper to reprogram TCA cycle for cuproptosis-driven radiosensitization in esophageal cancer [0.03%]
GLS2抑制与铜协同作用重新编程三羧酸循环以驱动食管癌的铜死亡放射增敏作用
Wang Jing,Wenhao Wang,Yi Ding et al.
Wang Jing et al.
Esophageal squamous cell carcinoma (ESCC) is notorious for its poor prognosis. In the present study, the role of glutaminase 2 (GLS2) and copper (Cu) in the radiosensitivity of ESCC was explored. Both in vitro and in vivo experiments were c...