Stem cell engineering for the generation of allogeneic CAR-directed natural killer T cells targeting endometrial carcinoma [0.03%]
用于靶向子宫内膜癌的同种异体CAR定向自然杀伤T细胞生成的干细胞工程学
Yan-Ruide Li,Gabriella A DiBernardo,Yuning Chen et al.
Yan-Ruide Li et al.
Background: Aggressive subtypes of uterine endometrial carcinoma (UEC) often result in mortality due to recurrence of disease with chemoresistant tumor cells surrounded by an immune suppressive microenvironment. Current C...
Hijacking the helpers: platelet and neutrophil trafficking in AML and therapeutic exploitation [0.03%]
狡兔多窟：急性髓系白血病中血小板和中性粒细胞的交通法则与治疗干预
Farshad Heydari,Michael R Hamblin,Jalal Naghinezhad
Farshad Heydari
Acute myeloid leukemia (AML) remains one of the most aggressive and treatment-resistant hematologic malignancies, driven by clonal expansion of immature myeloid blasts in the bone marrow and peripheral blood. Current therapies-chemotherapy ...
Epigenetic and post-translational regulatory networks of ferroptosis in the tumor immune microenvironment [0.03%]
肿瘤免疫微环境中铁死亡表观遗传和翻译后调控网络
Linna Du,Yueyue Zhang,Jianchang Luo et al.
Linna Du et al.
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent membrane lipid peroxidation. The tumor immune microenvironment (TIME) significantly influences ferroptosis sensitivity in both cancer and immune cells. Rece...
Defining the cellular and molecular identities of histologic subtypes in lung adenocarcinoma [0.03%]
确定肺腺癌组织学亚型的细胞和分子特征
Jusung Lee,Ji Yun Jeong,Mi Jeong Hong et al.
Jusung Lee et al.
Background: Tumor histology reflects disease aggressiveness and clinical outcomes in cancer patients. Lung adenocarcinomas (LUADs) are classified based on predominant histologic patterns, including high-grade micropapilla...
Resilience of human tolerogenic dendritic cells to physiological oxygen supports clinical application: functional stability amidst glycolytic and differentiation shifts [0.03%]
人耐受性树突状细胞对生理氧气的抵抗力支持其临床应用：糖酵解和分化转移中的功能稳定性
Antonia Peter,Tamara Traitteur,Sara Calitz et al.
Antonia Peter et al.
Tolerogenic dendritic cells (tolDCs) hold promise for treating autoimmune diseases, potentially restoring antigen-specific immune tolerance without systemic immunosuppression. However, their behavior in vivo remains incompletely understood,...
ELK1 promotes the progress of myeloid leukemia by hindering the differentiation of neutrophils [0.03%]
ELK1通过抑制中性粒细胞分化促进髓系白血病进展
Yuhan He,Ya Zhou,Dexin Wen et al.
Yuhan He et al.
Background: The genes controlling lineage determination and differentiation tend to be essential for the development of acute myeloid leukemia (AML). Identifying novel target genes capable of promoting the differentiation...
Mingyi Xu,Dexiao Kong,Shan Sun et al.
Mingyi Xu et al.
The emergence of organoids has received widespread attention for faithful recapitulation of physiological and pathological conditions, together with overcoming the major bottleneck of extrapolating laboratory findings from model systems to ...
Gastric and upper gastrointestinal oncology: integrating breakthroughs from prevention to precision therapeutics [0.03%]
胃和上消化道肿瘤学：从预防到精准治疗的突破整合
JunLi Chen,JiLong Wang,LuLu Cai et al.
JunLi Chen et al.
Gastric and upper gastrointestinal (GI) oncology is at a point of transformation, with significant advances in each aspect of the disease continuum. Novel clinical tools and therapies, including randomized phase II and III trials, have prov...
Crosstalk between ferroptosis and extracellular vesicles in cancer: from interaction to clinical application [0.03%]
细胞焦亡与癌外泌体的相互作用及临床应用研究进展
Jingyi Liu,Kewei Wang,Zhixiong Hao et al.
Jingyi Liu et al.
Cancer continues to pose a significant issue to public health. Despite the considerable advancements in popular therapies such as surgery, radiation, chemotherapy, targeted therapy, and immunotherapy, a substantial number of patients contin...
Hypoxia promotes BCMA loss and a suppressive secretome thereby hindering CAR T cell therapy in multiple myeloma [0.03%]
缺氧通过促进BCMA丢失和产生抑制性细胞因子分泌灶从而妨碍CAR-T细胞治疗多发性骨髓瘤
Chenggong Tu,Arne Van der Vreken,Fien Meeus et al.
Chenggong Tu et al.
Introduction: Multiple myeloma (MM) develops in the hypoxic bone marrow (BM) microenvironment, which alters tumor behavior and immune responses. While hypoxia is known to directly suppress immune function, its effect on i...