Long-term drug costs per life-month gained associated with first-line treatments for unresectable or metastatic melanoma [0.03%]
不可切除或转移性黑色素瘤一线治疗方案所获每生命月的长期药物成本分析
Jun S Liu,Sumati Rao
Jun S Liu
Background: For unresectable or metastatic melanoma, first-line ipilimumab has demonstrated long-term survival benefits over a 7-year period. First-line treatment with BRAF inhibitors has demonstrated efficacy in clinical...
Rare MLL-ELL fusion transcripts in childhood acute myeloid leukemia-association with young age and myeloid sarcomas? [0.03%]
儿童急性髓系白血病中罕见的MLL-ELL融合转录本与年龄小和粒细胞肉瘤有关？
Ioannis Panagopoulos,Ludmila Gorunova,Gitte Kerndrup et al.
Ioannis Panagopoulos et al.
Background: The chromosomal translocation t(11;19)(q23;p13) with a breakpoint within subband 19p13.1 is found mainly in acute myeloid leukemia (AML) and results in the MLL-ELL fusion gene. Variations in the structure of M...
New CD20 alternative splice variants: molecular identification and differential expression within hematological B cell malignancies [0.03%]
新的CD20选择性剪切变异体的分子鉴定及其在血液系统B细胞恶性肿瘤中的不同表达
Clémentine Gamonet,Elodie Bole-Richard,Aurélia Delherme et al.
Clémentine Gamonet et al.
Background: CD20 is a B cell lineage-specific marker expressed by normal and leukemic B cells and targeted by several antibody immunotherapies. We have previously shown that the protein from a CD20 mRNA splice variant (D3...
Heather C Murray,Vicki E Maltby,Doug W Smith et al.
Heather C Murray et al.
Background: The causative link between UV exposure and melanoma development is well known, however the mechanistic relationship remains incompletely characterised. UVA and UVB components of sunlight are implicated in mela...
Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph(+) leukemia [0.03%]
Ph+白血病中辅蛋白-1和-2的HSP40家族成员表达失调表明了蛋白质稳态失衡并可预测患者的预后状况
Margherita Vieri,Huimin Geng,John B Patterson et al.
Margherita Vieri et al.
Background: Proteostasis is defined by the orchestrated control of anabolic and catabolic protein pathways. Disruption of proteostasis results in cell stress and adaptation to proteostasis imbalance is mediated by adaptiv...
miR-199b, a novel tumor suppressor miRNA in acute myeloid leukemia with prognostic implications [0.03%]
一种新的急性髓系白血病抑癌微小核糖核酸miR-199b及其预后价值
Amanda J Favreau,Rose E McGlauflin,Christine W Duarte et al.
Amanda J Favreau et al.
Background: Dysregulation of miRNAs that can act as tumor suppressors or oncogenes can result in tumorigenesis. Previously we demonstrated that miR-199b was significantly downregulated in acute myeloid leukemia (AML) and ...
Patterns of hydroxyurea use and clinical outcomes among patients with polycythemia vera in real-world clinical practice: a chart review [0.03%]
羟基脲在真实世界中治疗真性红细胞增多症的使用情况和临床疗效：病历回顾分析
Shreekant Parasuraman,Marco DiBonaventura,Kelly Reith et al.
Shreekant Parasuraman et al.
Background: Hydroxyurea (HU) is among the most commonly used cytoreductive treatments for polycythemia vera (PV), but previous research and clinical experience suggest that not all patients respond optimally, consistently...
Ei Leen Liew,Marito Araki,Yumi Hironaka et al.
Ei Leen Liew et al.
Background: The gain-of-function mutation JAK2V617F is frequently found in Philadelphia-chromosome-negative myeloproliferative neoplasm (MPN) patients. However, the tumorigenic properties of JAK2V617F have mostly been cha...
Extranodal diffuse large B-cell lymphoma with monoclonal gammopathy: an aggressive and primary refractory disease responding to an immunomodulatory agent [0.03%]
弥漫性大B细胞淋巴瘤合并单克隆免疫球蛋白血症的治疗反应免疫调节剂的良好疗效
Patrizia Mondello,Vincenzo Pitini,Valeria Barresi et al.
Patrizia Mondello et al.
Background: Although the clinical outcome of patients with diffuse large B cell lymphoma (DLBCL) has been improved by the addition of rituximab to standard chemotherapy, almost one-third fails or relapses after first line...
Clinical outcomes among HR+/HER2- metastatic breast cancer patients with multiple metastatic sites: a chart review study in the US [0.03%]
美国HR阳性/HER2阴性转移性乳腺癌患者的临床结果：一项图表回顾研究（有多个转移部位的患者）
Jipan Xie,Yanni Hao,Nanxin Li et al.
Jipan Xie et al.
Background: Hormone receptor-positive, human epidermal growth factor receptor-2-negative (HR+/HER2-) is the most common type of metastatic breast cancer (mBC). While mBC patients generally have poor prognosis with limited...