Acquired factor VIII deficiency: two case reports and a review of literature [0.03%]
获得性 VIII 因子缺乏症：2 例报告及文献复习
Lan Mo,George C Bao
Lan Mo
Background: Acquired factor VIII (FVIII) deficiency, or acquired hemophilia A (AHA), is a rare autoimmune disorder involving antibody-mediated depletion of coagulation FVIII, leading to severe, life-threatening bleeding. ...
nab-Paclitaxel for the treatment of breast cancer: an update across treatment settings [0.03%]
nab-紫杉醇治疗乳腺癌的新进展：全面解读不同治疗场景下的应用更新
Adam Brufsky
Adam Brufsky
Purpose: The purpose of this systematic review is to discuss recent studies and ongoing trials of nab-paclitaxel in breast cancer and to examine the potential role of nab-paclitaxel as a backbone for immuno-oncology thera...
Metastatic BRAF K601E-mutated melanoma reaches complete response to MEK inhibitor trametinib administered for over 36 months [0.03%]
BRAF K601E突变的转移性黑色素瘤对 trametinib 治疗达完全缓解，疗程超过36个月
Riccardo Marconcini,Luca Galli,Andrea Antonuzzo et al.
Riccardo Marconcini et al.
Background: The BRAF K601E mutation occurs in 5% of patients with melanoma, and is the third most common type of BRAF mutation. However, treatment with BRAF and mitogen-activated extracellular signal-regulated kinase (MEK...
A randomized exploratory phase 2 study in patients with chemotherapy-related peripheral neuropathy evaluating whole-body vibration training as adjunct to an integrated program including massage, passive mobilization and physical exercises [0.03%]
化疗相关外周神经病变患者的探索性II期随机研究，评估全身振动训练联合按摩、被动活动和物理锻炼的综合方案中的辅助作用
Stefan S Schönsteiner,Heidi Bauder Mißbach,Axel Benner et al.
Stefan S Schönsteiner et al.
Background: Chemotherapy-induced polyneuropathy (CIPN) is a common toxicity after chemotherapy, immunomodulatory drugs or proteasome inhibitors, which is difficult to treat and may also have impact on quality of life. The...
Atypical hemolytic uremic syndrome in first trimester pregnancy successfully treated with eculizumab [0.03%]
依库珠单抗治疗孕早期溶血性尿毒综合征1例报告
Gabriela Andries,Michael Karass,Srikanth Yandrapalli et al.
Gabriela Andries et al.
Background: Atypical hemolytic uremic syndrome is a rare disorder which is known to cause acute thrombotic microangiopathy during pregnancy with poor maternal and fetal outcomes. Atypical hemolytic uremic syndrome is caus...
Molecular classification of tissue from a transformed non-Hogkin's lymphoma case with unexpected long-time remission [0.03%]
转化型非霍奇金淋巴瘤意外长期缓解组织的分子分类
Julie Støve Bødker,Marianne Tang Severinsen,Tarec Christoffer El-Galaly et al.
Julie Støve Bødker et al.
Background: The concept of precision medicine in cancer includes individual molecular studies to predict clinical outcomes. In the present N = 1 case we retrospectively have analysed lymphoma tissue by exome sequencing an...
Loss of quiescence and self-renewal capacity of hematopoietic stem cell in an in vitro leukemic niche [0.03%]
体外白血病生态位中造血干细胞失去静息态和自我更新能力
Natalia-Del Pilar Vanegas,Jean-Paul Vernot
Natalia-Del Pilar Vanegas
Background: Leukemic and mesenchymal stem cells interact in the leukemic microenvironment and affect each other differently. This interplay has also important implications for the hematopoietic stem cell (HSC) biology and...
Dabrafenib and trametinib activity in a patient with BRAF V600E mutated and microsatellite instability high (MSI-H) metastatic endometrial cancer [0.03%]
达拉菲尼和曲美替尼治疗BRAF V600E突变型微卫星高度不稳定型晚期子宫内膜癌1例报告
Michele Moschetta,Gabriel Mak,Joana Hauser et al.
Michele Moschetta et al.
Background: Targeting BRAF V600E mutation has been proven effective in the treatment of several types of cancer. In endometrial adenocarcinoma, the BRAF V600E mutation has been rarely reported. Whether targeting BRAF onco...
Ningfei An,Bo Cen,Houjian Cai et al.
Ningfei An et al.
Background: Receptor tyrosine kinase, c-Kit (CD117) plays a pivotal role in the maintenance and expansion of hematopoietic stem/progenitor cells (HSPCs). Additionally, over-expression and/or mutational activation of c-Kit...
Shuyong Wei,Kankan Wang
Shuyong Wei
Long noncoding RNAs (lncRNAs) have emerged as a class of pivotal regulators of gene expression. Recent studies have shown that lncRNAs contribute to the initiation, maintenance, and development of acute myeloid leukemia (AML). In this revie...