Low-dose methotrexate in sickle-cell disease: a pilot study with rationale borrowed from rheumatoid arthritis [0.03%]
低剂量甲氨蝶呤治疗镰状细胞病的初步研究：从类风湿性关节炎中借鉴的理论基础
Silvia R Brandalise,Rosemary Assis,Angelo B A Laranjeira et al.
Silvia R Brandalise et al.
Background: Inflammation is a major feature of sickle cell disease (SCD). Low-dose methotrexate (MTX) has long been used in chronic inflammatory diseases. This pilot study examined the MTX effect on acute vaso-occlusive p...
Ying Li,Xin Wang
Ying Li
Cullin 4B (CUL4B) is a scaffold of the Cullin4B-Ring E3 ligase complex (CRL4B) that plays an important role in proteolysis and is implicated in tumorigenesis. Aberrant expression of CUL4B has been reported in various types of human diseases...
Clinical implications of c-maf expression in plasma cells from patients with multiple myeloma [0.03%]
多发性骨髓瘤患者浆细胞中c-maf表达的临床意义
GuoQing Wei,LiJun Wang,HanJin Yang et al.
GuoQing Wei et al.
Background: Multiple myeloma (MM) is a type of hematological malignancy with significant heterogeneity in clinical features and prognosis. Cytogenetic abnormalities are the major factors affecting patient outcomes. Studie...
In vivo and in situ programming of tumor immunity by combining oncolytics and PD-1 immune checkpoint blockade [0.03%]
溶瘤病毒与PD-1免疫检查点抑制剂联用的体内和原位肿瘤免疫编程作用
Eric Bartee,Zihai Li
Eric Bartee
Blockade of the programmed cell death protein 1 (PD1) pathway is clinically effective against human cancers. Although multiple types of malignancies have been shown to respond to PD1 agents, only a small percentage of patients typically ben...
Changes in clinical laboratory parameters and pharmacodynamic markers in response to blinatumomab treatment of patients with relapsed/refractory ALL [0.03%]
布鲁纳图莫单抗治疗复发/难治性急性淋巴细胞白血病患者临床实验室指标和药效学标志物的变化
Virginie Nägele,Andrea Kratzer,Gerhard Zugmaier et al.
Virginie Nägele et al.
Background: Blinatumomab has shown a remission rate of 69% in an exploratory single-arm, phase II dose-escalation study in adult patients with relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL). We evaluat...
Cyclosporine is a potential curative treatment option for advanced thymoma [0.03%]
环孢素可能是晚期胸腺瘤的潜在根治性治疗选择
Yusuke Isshiki,Hiroaki Tanaka,Yoshio Suzuki et al.
Yusuke Isshiki et al.
Background: Thymectomy can effectively cure most thymoma patients; however, patients with advanced thymoma typically require chemotherapy, which is associated with limited efficacy in this context. Here we provide the fir...
The development of bispecific antibodies and their applications in tumor immune escape [0.03%]
双特异性抗体的开发及其在肿瘤免疫逃逸中的应用
Xiaolong Zhang,Yuanyuan Yang,Dongmei Fan et al.
Xiaolong Zhang et al.
During the past two decades, a great evolution of bispecific antibodies (BsAbs) for therapeutic applications has been made. BsAbs can bind simultaneously two different antigens or epitopes, which leads to a wide range of applications includ...
Natasha Garg,Constance Stoehr,Yan Shi Zhao et al.
Natasha Garg et al.
Background: Esophageal cancer including squamous cell carcinoma (SCC) and adenocarcinoma represents 4% of all cancers in the United States. Patients with esophageal cancer frequently present with locally advanced disease,...
Advances of CD19-directed chimeric antigen receptor-modified T cells in refractory/relapsed acute lymphoblastic leukemia [0.03%]
CD19导向的嵌合抗原受体修饰T细胞在难治复发急性淋巴细胞白血病中应用进展
Guoqing Wei,Lijuan Ding,Jiasheng Wang et al.
Guoqing Wei et al.
Refractory/relapsed B-cell acute lymphoblastic leukemia remains to be a significant cause of cancer-associated morbidity and mortality for children and adults. Developing novel and effective molecular-targeted approaches is thus a major pri...
Adult acute precursor B-cell lymphoblastic leukemia presenting as hypercalcemia and osteolytic bone lesions [0.03%]
以高钙血症和溶骨性骨损害表现为征的成人急性前体B细胞淋巴母细胞白血病
Nikki Charlotta Paul Granacher,Zwi N Berneman,Wilfried Schroyens et al.
Nikki Charlotta Paul Granacher et al.
Background: Osteolytic bone lesions and hypercalcemia without peripheral blasts B-cell acute lymphoblastic leukemia (B-ALL) is reported in children but rarely seen in adults. ...