Novel non-viral in vivo CAR-T therapies: latest updates from the 2025 ASH annual meeting [0.03%]
新型非病毒体内CAR-T疗法：2025年ASH年会最新报告
Bin Xue,Yifan Liu,Aibin Liang et al.
Bin Xue et al.
The field of chimeric antigen receptor (CAR)-T cell therapy is undergoing a paradigm shift from complex ex vivo manufacturing to direct in vivo generation of CAR-T cells. This innovative approach leverages non-viral delivery platforms to re...
Prospects and advances of PROTAC in the treatment of hematologic malignancies [0.03%]
蛋白降解嵌合体(PROTAC)在血液系统恶性肿瘤治疗中的前景和进展
Xinyang Wang,Ming Zhang,Heng Mei
Xinyang Wang
Over the past years, target protein degradation (TPD) has emerged as a hot topic in treating hematologic malignancies out of its strong ability to eliminate pathological proteins precisely. And as a flagship, Proteolysis-Targeting Chimeras ...
JingHui Liang,JunXi Wu,Yuan Zhang et al.
JingHui Liang et al.
KRAS is the most frequently altered oncogenic driver in human cancer. Its mutations drive the initiation and progression of many solid tumors. Clinical validation of covalent KRASG12C inhibitors marked a step change and renewed focus on all...
Efficacy and safety of ruxolitinib for graft-versus-host disease prophylaxis in patients with aplastic anemia undergoing PBSC-only allogeneic stem cell transplantation: a prospective phase II study [0.03%]
拉鲁利替尼预防性治疗骨髓增生异常综合征/阵发性夜間血红蛋白尿 Hybrid型向急性髓系白血病转型的临床研究
Xiaoyu Zhang,Lulu Pan,Yanhong Zhao et al.
Xiaoyu Zhang et al.
Background: While peripheral blood hematopoietic stem cell transplantation (PB-HSCT) supports rapid engraftment and reduces graft failure risk in aplastic anemia (AA) patients, it compromised higher risk of acute graft-ve...
In vivo CAR-T engineering: insights from the 2025 ASH annual meeting [0.03%]
2025年ASH年会解读：体内CAR-T工程化最新进展
Gelayol Asadi,Misagh Rajabinejad
Gelayol Asadi
In vivo chimeric antigen receptor (CAR)-T engineering is a prominent field of research in cancer immunology, in which vectors are used to reprogram endogenous T-cells into CAR-T cells. Viral and nonviral platforms presented at the 67th Annu...
Tertiary lymphoid structures correlate with reduced recurrence risk and enhanced antitumor immunity in esophageal squamous cell carcinoma with pathologic non-complete response to neoadjuvant chemoimmunotherapy [0.03%]
三级淋巴器官结构与新辅助化疗免疫治疗后病理不完全缓解的食管鳞癌患者的低复发风险和增强的抗肿瘤免疫力相关
Yang Wo,Tong Lu,Zijiang Yang et al.
Yang Wo et al.
Background: The majority of patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemoimmunotherapy (nCIT) failed to achieve pathologic complete response (pCR), had high risk of ...
Molecular background of Philadelphia chromosome dependent enhancement of cellular growth and tyrosine kinase inhibitor sensitivity [0.03%]
费城染色体依赖的细胞生长和酪氨酸激酶抑制剂敏感性增强的分子机制
Md Faruq Hossain,Lisa Hagenau,Lars R Jensen et al.
Md Faruq Hossain et al.
The Philadelphia chromosome is the result of a balanced reciprocal translocation between the long arms of chromosomes 9 and 22, resulting in the fusion gene BCR-ABL1. Despite it being a hallmark of acute lymphocytic leukemia (ALL), acute my...
Tumor-intrinsic PD-L1 drives lung cancer progression in response to TLR stimulation by promoting autophagy through the TRAF6-BECN1 signaling axis [0.03%]
肿瘤固有的PD-L1通过TRAF6-BECN1信号轴促进自噬来响应TLR刺激而驱动肺癌进展
Yoolim Sung,Ha-Jeong Lee,Mi-Jeong Kim et al.
Yoolim Sung et al.
Background: Programmed death-ligand 1 (PD-L1, CD274) is well known for its immunosuppressive function within the tumor microenvironment; however, its tumor cell-intrinsic roles remain incompletely characterized. Emerging ...
Single-cell profiling reveals FAM117A as a key regulator linking macrophage-epithelial crosstalk with the progression of lung adenocarcinoma [0.03%]
单细胞分析揭示FAM117A是连接肺癌巨噬细胞和上皮细胞交叉对话与疾病进展的关键因子
Chao Wu,Zhipeng Ren,Gang Che et al.
Chao Wu et al.
The tumor microenvironment (TME) has a profound influence on the progression of lung adenocarcinoma (LUAD) and its response to therapy. We identified a tumor-promoting communication network based on single-cell RNA sequencing. This shows an...
Matrix stiffness induces Ca2+-DCLK1-PIP5K1A mechanotransduction as a context-specific amplifier in pancreatic cancer progression and chemotherapy resistance [0.03%]
基质硬度通过Ca2+-DCLK1-PIP5K1A机械信号转导通路特异性地促进胰腺癌进展和化疗耐药性
Haoxiang Zhang,Chuanbing Zhao,Jiaoshun Chen et al.
Haoxiang Zhang et al.
Alterations in extracellular matrix (ECM) architecture and stiffness are hallmarks of aggressive pancreatic cancer progression. However, the mechanisms by which ECM biomechanical properties regulate malignant biological behavior remain unkn...