Exploring coding and signal joints of novel TCR beta D-D rearrangements for tracking T-cell leukemia clonality [0.03%]
探索新型TCRβD-D重排的编码和信号接头以追踪T细胞白血病克隆性
A M Miroshnichenkova,V K Ruppel,A O Smirnova et al.
A M Miroshnichenkova et al.
Rearranged T and B-cell receptor loci serve as critical clonal markers for studying adaptive immune system functioning during normal immune response and abnormal expansion in lymphoid malignancies. Analyses of both complete and partial TCR/...
YAP-induced MAML1 cooperates with STAT3 to drive hepatocellular carcinoma progression [0.03%]
YAP诱导的MAML1与STAT3协同驱动肝细胞癌进展
Jiarong Li,Xi Li,Ronghao Wang et al.
Jiarong Li et al.
Hepatocellular carcinoma (HCC) is a major liver malignancy and a leading cause of cancer-related mortality worldwide. Given its rising incidence and poor prognosis, there is an urgent need to elucidate the molecular mechanisms driving HCC p...
NAT10-mediated lipid metabolic reprogramming drives EGFR-TKI resistance in non-small cell lung cancer via ac4C-dependent mRNA stabilization [0.03%]
NAT10介导的脂质代谢重编程通过ac4C依赖性mRNA稳定驱动非小细胞肺癌中EGFR-TKI耐药性
Shuai Fang,Yuchao Zhu,Wei Chen et al.
Shuai Fang et al.
The development of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment represents a significant challenge to targeted therapies for lung cancer. To explore the feasibility of epigenetic therapy in...
Emerging strategies in CAR-T cell therapy for acute myeloid leukemia: overcoming heterogeneity and improving safety through dual-antigen targeting [0.03%]
针对急性髓系白血病的CAR-T细胞治疗新兴策略：通过双靶点作用克服异质性及提高安全性
Ángeles Ocaña-Cara,Tuna Mutis,Jort J van der Schans
Ángeles Ocaña-Cara
While CAR-T cell therapy has been very successful for treating B cell malignancies, and more recently multiple myeloma, achieving clinical success for acute myeloid leukemia (AML) remains a significant challenge. The examination of current ...
Development and clinical trial of M701, an Anti-EpCAM × Anti-CD3 bispecific antibody: a targeted intraperitoneal therapy for malignant ascites stemming from advanced solid tumors [0.03%]
M701（一种抗EpCAM×抗CD3双特异性抗体）的开发及临床试验：一种治疗晚期实体瘤癌性腹水的靶向腹腔内疗法
Rongrui Liu,Rongbo Lin,Ning Li et al.
Rongrui Liu et al.
Background: Malignant ascites (MA) is one of the major complications in advanced epithelial cancer patients and is associated with poor prognosis, poor quality of life, and severe symptoms. No efficient medicine is availa...
In vivo CAR-T cell engineering: concept, research progress, potential challenges and enhancement strategies [0.03%]
体内CAR-T细胞工程：概念、研究进展、潜在挑战及增强策略
Yizhao Chen,Qianling Xin,Jiaqi Qiu et al.
Yizhao Chen et al.
After decades of development and accumulation, chimeric antigen receptor (CAR)-T therapy has become a revolutionary immunotherapy method, which has triggered changes in treatment methods and concepts in the fields of cancer, autoimmune diso...
Spatial ecostructural modelling of endometrial cancer identifies the key role of CD90 + CD105 + endothelial cells in tumour heterogeneity and predicts disease recurrence [0.03%]
空间生态结构模型揭示了子宫内膜癌中CD90+ CD105+ 内皮细胞在肿瘤异质性中的关键作用并预测疾病复发
Di Wu,Cinian Lv,Zhifeng Yan et al.
Di Wu et al.
Background: Current therapeutic strategies for endometrial cancer are mainly based on aggressive histological types and molecular subtypes. However, ignoring the spatial distribution of immune/stromal cells fails to accou...
Targeting platelet-tumor cell interactions via thromboxane A2-prostanoid receptor blockade to reduce metastasis in triple negative breast cancer [0.03%]
通过阻断血小板-肿瘤细胞相互作用中的 thromboxane a2 前列腺素受体来减少三阴性乳腺癌的转移
Veeresh Toragall,Ann C Rester,Salma Begum et al.
Veeresh Toragall et al.
In addition to their central role in blood hemostasis, it is increasingly clear that platelets contribute to multiple steps in the metastatic cascade. Platelets are one of the most abundant cells with which tumor cells interact once they en...
Immunotherapy for small cell lung cancer: current challenges and prospects [0.03%]
小细胞肺癌的免疫治疗：当前挑战与前景展望
Jiaxin Zhong,Guangling Jie,Haorui Qin et al.
Jiaxin Zhong et al.
Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy with limited treatment options. While immunotherapy has revolutionized SCLC therapy and now serves as a front-line treatment, the disease continues to present si...
Correction: Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion [0.03%]
订正：多模型分析发现氧化低密度脂蛋白吸收性中性粒细胞在促进肝内胆囊癌侵袭中的作用
Dongning Rao,Jiaxin Li,Mao Zhang et al.
Dongning Rao et al.
Published Erratum
Experimental hematology & oncology. 2025 Nov 5;14(1):129. DOI:10.1186/s40164-025-00722-8 2025