ELK1 promotes the progress of myeloid leukemia by hindering the differentiation of neutrophils [0.03%]
ELK1通过抑制中性粒细胞分化促进髓系白血病进展
Yuhan He,Ya Zhou,Dexin Wen et al.
Yuhan He et al.
Background: The genes controlling lineage determination and differentiation tend to be essential for the development of acute myeloid leukemia (AML). Identifying novel target genes capable of promoting the differentiation...
Mingyi Xu,Dexiao Kong,Shan Sun et al.
Mingyi Xu et al.
The emergence of organoids has received widespread attention for faithful recapitulation of physiological and pathological conditions, together with overcoming the major bottleneck of extrapolating laboratory findings from model systems to ...
Gastric and upper gastrointestinal oncology: integrating breakthroughs from prevention to precision therapeutics [0.03%]
胃和上消化道肿瘤学：从预防到精准治疗的突破整合
JunLi Chen,JiLong Wang,LuLu Cai et al.
JunLi Chen et al.
Gastric and upper gastrointestinal (GI) oncology is at a point of transformation, with significant advances in each aspect of the disease continuum. Novel clinical tools and therapies, including randomized phase II and III trials, have prov...
Crosstalk between ferroptosis and extracellular vesicles in cancer: from interaction to clinical application [0.03%]
细胞焦亡与癌外泌体的相互作用及临床应用研究进展
Jingyi Liu,Kewei Wang,Zhixiong Hao et al.
Jingyi Liu et al.
Cancer continues to pose a significant issue to public health. Despite the considerable advancements in popular therapies such as surgery, radiation, chemotherapy, targeted therapy, and immunotherapy, a substantial number of patients contin...
Hypoxia promotes BCMA loss and a suppressive secretome thereby hindering CAR T cell therapy in multiple myeloma [0.03%]
缺氧通过促进BCMA丢失和产生抑制性细胞因子分泌灶从而妨碍CAR-T细胞治疗多发性骨髓瘤
Chenggong Tu,Arne Van der Vreken,Fien Meeus et al.
Chenggong Tu et al.
Introduction: Multiple myeloma (MM) develops in the hypoxic bone marrow (BM) microenvironment, which alters tumor behavior and immune responses. While hypoxia is known to directly suppress immune function, its effect on i...
Synthetic essentiality of isoprenylcysteine carboxylmethyltransferase in PTEN deficient triple negative breast cancer [0.03%]
PTEN缺陷三阴性乳腺癌中牻牛儿基半胱氨酸羧甲基转移酶的合成致死效应
Byung-Sun Park,Jaeyeol Kim,Dong-Chan Seo et al.
Byung-Sun Park et al.
PTEN deficiency is frequently observed in various cancers, including triple-negative breast cancer. However, PTEN loss-of-function mutations are not directly druggable, necessitating a synthetic lethality approach for treating PTEN-deficien...
PRL-3 up-regulates exosomal ITGαvβ5 expression to promote liver pre-metastatic niche formation and colon cancer liver metastasis [0.03%]
PRL-3通过上调exo-ITGαvβ5促进肝前期转移灶形成及结肠癌肝转移
Qiusheng Lan,Heyang Xu,Yujie Zeng et al.
Qiusheng Lan et al.
Liver pre-metastatic niches (PMN) formation is a pivotal process in colorectal cancer liver metastasis (CLM). Phosphatase of regenerating liver-3 (PRL-3) has been demonstrated as a key factor in promoting CRC progression (e.g., therapeutic ...
Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy [0.03%]
Tetrahydromagnolol靶向TRIM38介导癌细胞PANoptosis并具有协同抗肿瘤潜力
Xiaoqing Gu,Lin Li,Ting Duan et al.
Xiaoqing Gu et al.
Background: Tetrahydromagnolol (THM) is a compound isolated from Magnolia officinalis with unique chemical structure and composition. However, its anticancer effect of THM and the underlying molecular mechanisms remain un...
The lncRNA PARylator promotes PARP1 activation and resistance to DNA‑damaging therapy in esophageal squamous cell carcinoma [0.03%]
长链非编码RNA PARylator通过促进PARP1激活以增强食管鳞癌细胞对DNA损伤治疗的耐药性
Teng Fei Qi,Yadong Liu,Jinkun Yang et al.
Teng Fei Qi et al.
Background: Outcomes for patients with esophageal squamous cell carcinoma (ESCC) remain poor, partly due to treatment resistance, particularly to DNA-damaging therapies. Poly(ADP‑ribose) polymerase 1 (PARP1) plays a crit...
Efficacy of melflufen in multiple myeloma with mutated or deleted TP53 [0.03%]
梅氟伦治疗TP53突变或缺失的多发性骨髓瘤的有效性和安全性
Klara Acs,Juho J Miettinen,Philipp Sergeev et al.
Klara Acs et al.
Patients with multiple myeloma bearing a deletion of chromosome 17p (del(17p)), mutation of TP53, or both have poorer prognosis compared to patients without these aberrations. We investigated the activity and mechanism of melflufen (melphal...