Metabolic drivers of genome instability in cancer: mechanisms and therapeutic opportunities [0.03%]
癌症基因组不稳定的代谢驱动因素：机制和治疗机会
Yu-Shun Wang,Li-Heng Qian,Cui-Cui Liu et al.
Yu-Shun Wang et al.
Metabolic reprogramming and genome instability represent two fundamental hallmarks of cancer. Emerging studies now demonstrate that specific metabolic alterations directly fuel replication stress, DNA damage, and compromised DNA damage resp...
Decoding the spatiotemporal characteristics of ferroptosis: reshaping tumour therapeutic strategies [0.03%]
铁死亡时空特征解析及重塑肿瘤治疗策略
Lizhou Song,Yue Shu,Tian Zhou et al.
Lizhou Song et al.
The resistance to treatment and the high chance of death associated with cancer still remain key problems that need breakthrough in biology and medicine. Ferroptosis is a newly discovered form of regulated cell death that is driven by iron ...
Correction: Novel non-viral in vivo CAR-T therapies: latest updates from the 2025 ASH annual meeting [0.03%]
Correction：新型非病毒体内CAR-T疗法：2025年ASH年会上的最新更新
Bin Xue,Yifan Liu,Aibin Liang et al.
Bin Xue et al.
Published Erratum
Experimental hematology & oncology. 2026 Apr 6;15(1):41. DOI:10.1186/s40164-026-00772-6 2026
Multi-omics analysis of patient-derived organoids reveals that E3 ligase COP1 promotes liver metastasis and oxaliplatin resistance in colorectal cancer through LUZP1 degradation and MYL9 phosphorylation [0.03%]
基于患者来源的类器官多组学分析揭示E3泛素连接酶COP1通过LUZP1降解和MYL9磷酸化促进结直肠癌肝转移和奥沙利铂耐药性
Ruijia Zhang,Wenqin Luo,Qikai Zhou et al.
Ruijia Zhang et al.
Colorectal cancer liver metastasis (CRLM) and chemotherapy resistance remain major clinical challenges, with the underlying molecular mechanisms yet to be fully elucidated. In this study, based on analyses of five initial clinical cohorts f...
Clinical and translational advances in regulatory T cell-based strategies in allogeneic hematopoietic stem cell transplantation: highlights from ASH 2025 [0.03%]
适应性调节T细胞在同种异体造血干细胞移植中的临床及转化研究进展：来自2025年ASH会议的亮点报告
Somayeh Yazdanparast,Saeid Abroun,Tahereh Rostami et al.
Somayeh Yazdanparast et al.
Regulatory T cells (Tregs), winners of the 2025 Nobel Prize in Physiology or Medicine, emerged as an unsung giant of peripheral immune tolerance after allogeneic hematopoietic stem cell transplantation (allo-HSCT). These cells exert influen...
Intrinsic immune properties of carrier MSC impact on the clinical outcome of children with solid tumors receiving oncolytic virotherapy [0.03%]
载体间充质干细胞的内在免疫特性影响儿童实体瘤患者病毒溶瘤治疗的临床疗效
Alvaro Morales-Molina,Lidia Franco-Luzón,Patricia Garcia-Rodriguez et al.
Alvaro Morales-Molina et al.
Our previous clinical data showed that autologous mesenchymal stromal cells (MSCs) can be used as carriers for the systemic delivery of oncolytic adenoviruses in children with advanced cancers, a therapy known as Celyvir. Despite achieving ...
Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis [0.03%]
GPX4和TXNRD1双靶点通过诱导凋亡和铁死亡触发AML细胞根除
Cécile Favreau,Maxence Bourgoin,Coline Savy et al.
Cécile Favreau et al.
Myelodysplastic syndromes (MDS) are hematological disorders associated with bone marrow failure and abnormal hematopoietic cell growth, often progressing to acute myeloid leukemia (AML). Current treatments for AML and high-risk MDS are limi...
The novel retinoid WYC-209 sensitizes multiple myeloma to carfilzomib via epigenetically upregulating ZMYND8 [0.03%]
新颖的维甲酸WYC-209通过表观遗传学上调ZMYND8来使卡非佐米敏化多发性骨髓瘤
Jiaxuan Xu,Jie Yan,Haoyu Zhang et al.
Jiaxuan Xu et al.
Carfilzomib (CFZ) is a cornerstone therapy for patients with relapsed multiple myeloma (MM); however, poor prolonged treatment response remains a major clinical limitation. ZMYND8 overexpression increases the sensitivity of MM cells to CFZ....
Functional xenogeneic hematopoietic cells maintaining donor-dominant identity and immune tolerance enable therapy [0.03%]
具有供体主导身份和免疫耐受功能的异基因造血细胞能够维持移植治疗
Shumin Xiong,Ren Zhou,Chuijin Wei et al.
Shumin Xiong et al.
Background: The clinical supply of hematopoietic cells is severely constrained by the limitations of donor donation and inefficient in vitro generation. While generating these cells within interspecies chimeras presents a...
RNA-based co-transfer of human CD8αβ with WT1-specific TCRαβ redirects tumor recognition by CD4 and γδ T-cells towards MHC class I-restricted WT1 epitopes and boosts CD8 T-cell responses with or without CD3 mRNA [0.03%]
基于RNA共传递人CD8αβ与WT1特异性TCRαβ将CD4和γδT细胞重定向至MHC-I限制性WT1表位并增强有或无CD3mRNA的CD8T细胞反应
Diana Campillo-Davo,Donovan Flumens,Zwi N Berneman et al.
Diana Campillo-Davo et al.
We evaluated the redirection of CD4, γδ and CD8 T-cells towards the Wilms' tumor protein (WT1) tumor-associated antigen, using a major histocompatibility complex (MHC) class I-restricted WT1-specific T-cell receptor (TCR) introduced via R...