Ubiquitin-centered post-translational modification crosstalk orchestrates tumor immunity and immunotherapy response [0.03%]
泛素调控的蛋白质翻译后修饰串扰操纵着肿瘤免疫及免疫治疗响应
Kailin Qiao,Leilei Wu,Letong Yang et al.
Kailin Qiao et al.
Remarkable progress has been made in cancer immunotherapy in recent years; however, it still faces challenges such as limited response rates, resistance, and immune-related adverse events. Ubiquitination, a key post-translational modificati...
Mutation rates in main tumour driver genes predict prognosis in patients with superficial spreading or nodular primary melanoma: results from the CARAMEL study by the Italian Melanoma Intergroup (IMI) [0.03%]
主要肿瘤驱动基因的突变率可预测浅表扩散型或结节型黑色素瘤患者的预后：意大利黑色素瘤研究组(CARAMEL研究)的结果
Maria Cristina Sini,Jerry Polesel,Sara Simi et al.
Maria Cristina Sini et al.
Superficial spreading melanoma (SSM) and nodular melanoma (NM) are the two histotypes that account for most cutaneous primary melanomas. We evaluated the mutational status for the genes underlying melanomagenesis among a series of SSMs and ...
The influence of neuro-tumor interactions on tumorigenesis and therapeutic response [0.03%]
神经肿瘤相互作用对肿瘤发生和治疗反应的影响
Xiaokang Wang,Yuanliang Yan,Liugen Li et al.
Xiaokang Wang et al.
The intricate crosstalk between the nervous system and tumors has emerged as a pivotal determinant of tumorigenesis, progression, and therapeutic response. This review synthesizes current insights into neuro-tumor interactions, highlighting...
Obesity- and tumor-derived signals drive cancer-associated state transitions in breast mesenchymal stromal/stem cells reprogrammed by IL1RA or JAK inhibition [0.03%]
肥胖和肿瘤衍生信号驱动乳腺间充质基质/干细胞通过IL1RA或JAK抑制重编程后的癌症相关状态转变
Andreas Ritter,Samira Catharina Hoock,Nina-Naomi Kreis et al.
Andreas Ritter et al.
The tumor microenvironment (TME) in breast cancer is shaped by reciprocal interactions between cancer cells and their surrounding stromal populations. Here, we show that breast adipose tissue-derived stromal/stem cells (bASCs) undergo disti...
Single-cell profiling reveals reprogrammed hierarchy and disrupted immune-stromal ecosystem in TP53-mutated AML [0.03%]
单细胞测序揭示TP53突变AML中再编程的分层模式和紊乱的免疫-基质生态系统
Guo Qiu,Zhao Yin,Xiaoyue Lu et al.
Guo Qiu et al.
Background: TP53-mutated acute myeloid leukemia (AML) represents one of the most adverse-risk subtypes of AML, yet the mechanisms underlying its resistance and relapse remain poorly defined. ...
Stem cell engineering for the generation of allogeneic CAR-directed natural killer T cells targeting endometrial carcinoma [0.03%]
用于靶向子宫内膜癌的同种异体CAR定向自然杀伤T细胞生成的干细胞工程学
Yan-Ruide Li,Gabriella A DiBernardo,Yuning Chen et al.
Yan-Ruide Li et al.
Background: Aggressive subtypes of uterine endometrial carcinoma (UEC) often result in mortality due to recurrence of disease with chemoresistant tumor cells surrounded by an immune suppressive microenvironment. Current C...
Hijacking the helpers: platelet and neutrophil trafficking in AML and therapeutic exploitation [0.03%]
狡兔多窟：急性髓系白血病中血小板和中性粒细胞的交通法则与治疗干预
Farshad Heydari,Michael R Hamblin,Jalal Naghinezhad
Farshad Heydari
Acute myeloid leukemia (AML) remains one of the most aggressive and treatment-resistant hematologic malignancies, driven by clonal expansion of immature myeloid blasts in the bone marrow and peripheral blood. Current therapies-chemotherapy ...
Epigenetic and post-translational regulatory networks of ferroptosis in the tumor immune microenvironment [0.03%]
肿瘤免疫微环境中铁死亡表观遗传和翻译后调控网络
Linna Du,Yueyue Zhang,Jianchang Luo et al.
Linna Du et al.
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent membrane lipid peroxidation. The tumor immune microenvironment (TIME) significantly influences ferroptosis sensitivity in both cancer and immune cells. Rece...
Defining the cellular and molecular identities of histologic subtypes in lung adenocarcinoma [0.03%]
确定肺腺癌组织学亚型的细胞和分子特征
Jusung Lee,Ji Yun Jeong,Mi Jeong Hong et al.
Jusung Lee et al.
Background: Tumor histology reflects disease aggressiveness and clinical outcomes in cancer patients. Lung adenocarcinomas (LUADs) are classified based on predominant histologic patterns, including high-grade micropapilla...
Resilience of human tolerogenic dendritic cells to physiological oxygen supports clinical application: functional stability amidst glycolytic and differentiation shifts [0.03%]
人耐受性树突状细胞对生理氧气的抵抗力支持其临床应用：糖酵解和分化转移中的功能稳定性
Antonia Peter,Tamara Traitteur,Sara Calitz et al.
Antonia Peter et al.
Tolerogenic dendritic cells (tolDCs) hold promise for treating autoimmune diseases, potentially restoring antigen-specific immune tolerance without systemic immunosuppression. However, their behavior in vivo remains incompletely understood,...