Tertiary lymphoid structures correlate with reduced recurrence risk and enhanced antitumor immunity in esophageal squamous cell carcinoma with pathologic non-complete response to neoadjuvant chemoimmunotherapy [0.03%]
三级淋巴器官结构与新辅助化疗免疫治疗后病理不完全缓解的食管鳞癌患者的低复发风险和增强的抗肿瘤免疫力相关
Yang Wo,Tong Lu,Zijiang Yang et al.
Yang Wo et al.
Background: The majority of patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemoimmunotherapy (nCIT) failed to achieve pathologic complete response (pCR), had high risk of ...
Molecular background of Philadelphia chromosome dependent enhancement of cellular growth and tyrosine kinase inhibitor sensitivity [0.03%]
费城染色体依赖的细胞生长和酪氨酸激酶抑制剂敏感性增强的分子机制
Md Faruq Hossain,Lisa Hagenau,Lars R Jensen et al.
Md Faruq Hossain et al.
The Philadelphia chromosome is the result of a balanced reciprocal translocation between the long arms of chromosomes 9 and 22, resulting in the fusion gene BCR-ABL1. Despite it being a hallmark of acute lymphocytic leukemia (ALL), acute my...
Tumor-intrinsic PD-L1 drives lung cancer progression in response to TLR stimulation by promoting autophagy through the TRAF6-BECN1 signaling axis [0.03%]
肿瘤固有的PD-L1通过TRAF6-BECN1信号轴促进自噬来响应TLR刺激而驱动肺癌进展
Yoolim Sung,Ha-Jeong Lee,Mi-Jeong Kim et al.
Yoolim Sung et al.
Background: Programmed death-ligand 1 (PD-L1, CD274) is well known for its immunosuppressive function within the tumor microenvironment; however, its tumor cell-intrinsic roles remain incompletely characterized. Emerging ...
Single-cell profiling reveals FAM117A as a key regulator linking macrophage-epithelial crosstalk with the progression of lung adenocarcinoma [0.03%]
单细胞分析揭示FAM117A是连接肺癌巨噬细胞和上皮细胞交叉对话与疾病进展的关键因子
Chao Wu,Zhipeng Ren,Gang Che et al.
Chao Wu et al.
The tumor microenvironment (TME) has a profound influence on the progression of lung adenocarcinoma (LUAD) and its response to therapy. We identified a tumor-promoting communication network based on single-cell RNA sequencing. This shows an...
Matrix stiffness induces Ca2+-DCLK1-PIP5K1A mechanotransduction as a context-specific amplifier in pancreatic cancer progression and chemotherapy resistance [0.03%]
基质硬度通过Ca2+-DCLK1-PIP5K1A机械信号转导通路特异性地促进胰腺癌进展和化疗耐药性
Haoxiang Zhang,Chuanbing Zhao,Jiaoshun Chen et al.
Haoxiang Zhang et al.
Alterations in extracellular matrix (ECM) architecture and stiffness are hallmarks of aggressive pancreatic cancer progression. However, the mechanisms by which ECM biomechanical properties regulate malignant biological behavior remain unkn...
Methods and applications of patient-derived organoid models for immune microenvironment and immunotherapy research in multiple cancer types [0.03%]
基于患者的类器官模型在多种癌症类型免疫微环境和免疫治疗研究中的应用方法
Yaya Yu,Yanan Li,Jiao Wang et al.
Yaya Yu et al.
Lack of pre-clinical models that simulate the complex TME and translate to human immunity is list as the top one challenge in the area of cancer immunotherapy development. While newly emerging organoid models play a crucial role in promotin...
Targeting epigenetic methylation: emerging diagnosis and therapeutic strategies in cancer [0.03%]
癌症表观遗传甲基化的新诊断和治疗策略
Youwen Zhu,Kun Liu,Hong Zhu
Youwen Zhu
Epigenetics shapes all aspects of cancer occurrence and progression. Among them, chromatin methylation is a particularly important regulator of oncogenic processes. The dynamic shifts in methylation can influence the development or death of...
Correction: The HSP90-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma [0.03%]
纠正：HSP90-MYC-CDK9网络驱动幕状细胞淋巴瘤的耐药性
Fangfang Yan,Vivian Jiang,Alexa Jordan et al.
Fangfang Yan et al.
Published Erratum
Experimental hematology & oncology. 2026 Feb 11;15(1):19. DOI:10.1186/s40164-025-00735-3 2026
From Amphiphiles to mRNA platforms: emerging vaccination strategies for pancreatic cancer [0.03%]
从两亲分子到mRNA平台：胰腺癌新兴疫苗策略
Dong Gun Lee,Kyunghee Noh
Dong Gun Lee
Pancreatic ductal adenocarcinoma (PDAC) remains among the deadliest cancers, with limited surgical eligibility, modest chemotherapy benefit, and resistance to immune checkpoint blockade. Two recent vaccine platforms have shown encouraging r...
Engineered extracellular vesicles displaying bi-specific T-cell engagers for targeted therapy of B-cell malignancies [0.03%]
用于B细胞肿瘤靶向治疗的工程化外泌体展示双特异性T细胞接合器
Xiuxiu Yang,Qian Xu,Jue Wang et al.
Xiuxiu Yang et al.
Despite the clinical success of T cell-based immunotherapies such as CAR-T cells and bispecific T cell engagers (BiTEs), therapeutic resistance and immune suppression remain significant barriers in B-cell malignancies. To address these, we ...