AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition [0.03%]
AOH1996通过抑制线粒体PCNA靶向白血病干细胞的线粒体动力学和代谢
HyunJun Kang,Melissa Valerio,Jia Feng et al.
HyunJun Kang et al.
Cytoplasmic proliferating cell nuclear antigen (PCNA) is highly expressed in acute myeloid leukemia (AML) cells, supporting oxidative metabolism and leukemia stem cell (LSC) growth. We report on AOH1996 (AOH), an oral compound targeting can...
Disrupting Notch signaling related HES1 in myeloid cells reinvigorates antitumor T cell responses [0.03%]
干扰髓样细胞中的Notch信号相关HES1可重新激活抗肿瘤T细胞反应
Myung Sup Kim,Hyeokgu Kang,Jung-Hwan Baek et al.
Myung Sup Kim et al.
Background: Tumor-associated macrophages (TAMs) are immunosuppressive cells within the tumor microenvironment (TME) that hinder anti-tumor immunity. Notch signaling is a pathway crucial for TAM differentiation and functio...
Chiglitazar diminishes the warburg effect through PPARγ/mTOR/PKM2 and increases the sensitivity of imatinib in chronic myeloid leukemia [0.03%]
氯格列扎罗通过PPARγ/mTOR/PKM2抑制Warburg效应并增加对慢性髓系白血病治疗药物伊马替尼的敏感性
Hongpeng Duan,Qian Lai,Yuelong Jiang et al.
Hongpeng Duan et al.
Background: A tyrosine kinase inhibitor (TKI) such as Imatinib (IM) is the preferred treatment for Chronic Myeloid Leukemia (CML). However, the emergence of IM resistance presents a significant challenge to disease manage...
Identification of a novel subtype of SPP1 + macrophages expressing SIRPα: implications for tumor immune evasion and treatment response prediction [0.03%]
识别一种新的SPP1+SIRPα+巨噬细胞亚型：对肿瘤免疫逃逸及治疗反应预测的意义
Kun Chen,Yida Li,Jianjiao Ni et al.
Kun Chen et al.
Background: SPP1 + macrophages are among the major phagocytic cells, yet promoting tumor immune evasion and predicting unfavorable prognosis, in various cancer types. Meanwhile, the predictive value of the abundance of SP...
Radiation-induced exosomal miR-21 enhances tumor proliferation and invasiveness in breast cancer: implications for poor prognosis in radiotherapy patients [0.03%]
放射诱导的外泌体miR-21增强乳腺癌肿瘤的增殖和侵袭性：放疗患者预后不良的潜在标志物研究
Kyungmin Kim,Kyung Oh Jung,Sera Oh et al.
Kyungmin Kim et al.
Radiotherapy is widely used as an effective non-surgical strategy to control malignant tumors. However, recurrence is one of common causes of treatment failure even after the effective radiotherapy. In this study, we focused on the effects ...
The development and application of chimeric antigen receptor natural killer (CAR-NK) cells for cancer therapy: current state, challenges and emerging therapeutic advances [0.03%]
嵌合抗原受体自然杀伤细胞(CAR-NK)用于癌症治疗的研究进展、挑战与前景
Pin Yao,Ya-Guang Liu,Gang Huang et al.
Pin Yao et al.
Immunotherapy has transformed the landscape of cancer treatment, with chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy emerging as a front runner in addressing some hematological malignancies. Despite its considerable effic...
Chimeric antigen receptor-T cell therapy for T cell-derived hematological malignancies [0.03%]
嵌合抗原受体T细胞治疗T细胞来源的血液系统肿瘤
Haiqiong Zheng,Houli Zhao,Shi Han et al.
Haiqiong Zheng et al.
Relapsed/refractory T cell-derived malignancies present with high heterogeneity and poor prognoses. Recently, chimeric antigen receptor (CAR)-T cell therapy has shown remarkable safety and efficacy in the treatment of B cell-derived maligna...
CUL4A-DDB1-circRFWD2 E3 ligase complex mediates the ubiquitination of p27 to promote multiple myeloma proliferation [0.03%]
CUL4A-DDB1-circRFWD2泛素连接酶复合体通过泛素化p27促进多发性骨髓瘤增殖
Jie Min,Jialei Mao,Hui Shi et al.
Jie Min et al.
Multiple myeloma (MM) is an incurable disease characterized by the abnormal expansion of plasma cells in the bone marrow (BM). Numerous studies have shown that BM tumor cells can influence the tumor microenvironment (TME) through communicat...
Malignant pleural effusion facilitates the establishment and maintenance of tumor organoid biobank with multiple patient-derived lung tumor cell sources [0.03%]
恶性胸腔积液可促进多种来源的肺肿瘤细胞系类器官生物库的建立和维持
Lingwei Wang,Yanli Yu,Yanhua Fang et al.
Lingwei Wang et al.
The Patient-Derived Organoids (PDOs) has demonstrated significant potential in personalized medicine. However, the initial establishment of lung cancer organoids (LCOs), and timely therapeutic recommendations face several challenges. Partic...
Natural killer cell biology and therapy in multiple myeloma: challenges and opportunities [0.03%]
多发性骨髓瘤中自然杀伤细胞的生物学和治疗：机遇与挑战
Kamlesh Bisht,Aimee Merino,Rob Igarashi et al.
Kamlesh Bisht et al.
Despite therapeutic advancements, multiple myeloma (MM) remains incurable. NK cells have emerged as a promising option for the treatment of MM. NK cells are heterogenous and typically classified based on the relative expression of their sur...