CD28 is superior to 4-1BB costimulation in generating CAR-NK cells for tumor immunotherapy [0.03%]
CD28在生成用于肿瘤免疫治疗的CAR-NK细胞方面优于4-1BB共刺激
Pengchao Zhang,Xuejia Feng,Xiangyun Niu et al.
Pengchao Zhang et al.
Chimeric antigen receptor (CAR)-NK therapy holds great potential for tumor treatment, but current CAR designs are primarily optimized for T cells, raising concerns about their suitability for NK cells. This study compared two dominant CAR d...
Dickkopf-1 promotes tumor progression of gefitinib- resistant non-small cell lung cancer through cancer cell-fibroblast interactions [0.03%]
Dickkopf-1通过癌细胞-成纤维细胞相互作用促进吉非替尼抗性非小细胞肺癌的肿瘤进展
Munkyung Choi,Yong June Choi,Young Joo Lee et al.
Munkyung Choi et al.
Background: Cancer cell-secreted proteins play a critical role in tumor progression and chemoresistance by influencing intercellular interactions within the tumor microenvironment. Investigating the intratumoral functions...
IRF1 is a core transcriptional regulatory circuitry member promoting AML progression by regulating lipid metabolism [0.03%]
IRF1通过调节脂质代谢促进AML进展的核心转录调控电路成员
Fenli Zhang,Zhiheng Li,Fang Fang et al.
Fenli Zhang et al.
Background: Acute myeloid leukemia (AML) is a prevalent malignancy of the hematologic system. Despite advancements in therapeutic approaches, significant heterogeneity and therapeutic resistance pose substantial challenge...
TLR7/8 signaling activation enhances the potency of human pluripotent stem cell-derived eosinophils in cancer immunotherapy for solid tumors [0.03%]
TLR7/8信号激活增强了人多能干细胞来源的嗜酸性粒细胞在实体肿瘤癌症免疫治疗中的效力
Sheng Zhu,Zhengyang Zhou,Ruixin Gu et al.
Sheng Zhu et al.
Background: Efficient tumor T-cell infiltration is crucial for the effectiveness of T-cell-based therapies against solid tumors. Eosinophils play crucial roles in recruiting T cells in solid tumors. Our group has previous...
TET2 downregulation enhances the antitumor efficacy of CD19 CAR T cells in a preclinical model [0.03%]
TET2下调增强了CD19 CAR T细胞在临床前模型中的抗肿瘤疗效
Yeongrin Kim,Moonjung Jeun,Heung Kyoung Lee et al.
Yeongrin Kim et al.
Chimeric antigen receptor (CAR) T cell therapy has demonstrated significant clinical efficacy in patients with hematologic cancers. However, long-term follow-up studies indicate that only 50% of patients remain in complete remission after t...
Suppression of CYLD by HER3 confers ovarian cancer platinum resistance via inhibiting apoptosis and by inducing drug efflux [0.03%]
HER3通过抑制凋亡和诱导药物外排来抑制CYLD从而导致卵巢癌铂类耐药
Ye Zhang,Jian-Ge Qiu,Wei Wang et al.
Ye Zhang et al.
Background: Ovarian cancer (OC) is the most pathogenic gynecological malignant tumor in the world. Due to the difficulty of early diagnosis, most of patients developed chemo-resistance and recurrence during/after chemothe...
A proinflammatory response and polarized differentiation of stromal elements characterizes the murine myeloma bone marrow niche [0.03%]
小鼠骨髓瘤骨髓龛以促炎反应和基质成分的极化分化为特征
Hussein Ghamlouch,Dylan C Gagler,Patrick Blaney et al.
Hussein Ghamlouch et al.
Background: The bone marrow (BM) niche contains non-hematopoietic elements including mesenchymal stromal cells (MSC) and bone marrow endothelial cells (BMEC) which provide mechanical support, and control hematopoietic cel...
Molecular profiling of skin cells identifies distinct cellular signatures in radiation-induced skin injury across various stages in the murine dataset [0.03%]
皮肤细胞的分子谱分析确定了小鼠数据集中各个阶段放疗引起皮肤损伤的不同细胞特征
Hongxuan Yu,Tao Zhong,Ying Xu et al.
Hongxuan Yu et al.
Background: Radiation-induced skin injury (RISI) commonly manifests in cancer patients undergoing radiotherapy (RT). However, a universally accepted standard for treating radiation injury has not yet been established. Our...
Alcohol accelerates the development of esophageal squamous cell carcinoma through elevated Gram-negative bacteria in peripheral circulation [0.03%]
酒精通过外周循环中革兰氏阴性菌的增加加速食管鳞状细胞癌的发展
Zehua Zhang,Le Kang,Yanfen Gu et al.
Zehua Zhang et al.
Alcohol consumption is intricately linked to the incidence of esophageal squamous cell carcinoma (ESCC). This study comprehensively investigates the role of alcohol-induced microbial alterations in ESCC progression. A retrospective analysis...
The CD64/CD28/CD3ζ chimeric receptor reprograms T-cell metabolism and promotes T-cell persistence and immune functions while triggering antibody-independent and antibody-dependent cytotoxicity [0.03%]
CD64/CD28/CD3ζ嵌合受体重组T细胞代谢，促进T细胞持续存在和免疫功能的同时引发不依赖抗体和依赖抗体的细胞毒性作用
Sara Caratelli,Francesca De Paolis,Domenico Alessandro Silvestris et al.
Sara Caratelli et al.
Background: Recent studies have shown that CD32/CD8a/CD28/CD3ζ chimeric receptor cells directly kill breast cancer cells, suggesting the existence of cell surface myeloid FcγR alternative ligands (ALs). Here, we investi...