Platelets in cancer and immunotherapy: functional dynamics and therapeutic opportunities [0.03%]
血小板在癌症和免疫治疗中的功能动态与治疗机会
Changjing Cai,Yiting Liu,Ruohuang Lu et al.
Changjing Cai et al.
Platelets play a critical role in tumor immunity, particularly in promoting cancer progression. Numerous studies suggest that platelets could serve as a novel target for cancer immunotherapy, however, no comprehensive reviews have yet summa...
Comprehensive molecular characterization of adult H3K27M mutated thalamic glioma long-term survivors [0.03%]
成人H3K27M突变thalamic胶质瘤长期生存者全面分子特征分析
Hao Xu,Xiaomu Hu,Biyun Wang et al.
Hao Xu et al.
H3K27-altered diffuse midline gliomas (H3-DMGs) represent aggressive tumors with fatal outcome and exceedingly rare cases have a long-term survival (LTS). We included 5 adult thalamic H3-DMG LTS and 13 short-term survivors (STS), and perfor...
Correction: IL‑6‑mediated tumorigenicity and antioxidant state in squamous cell carcinoma cells are driven by CD109 via stabilization of IL‑6 receptor‑alpha and activation of STAT3/NRF2 pathway [0.03%]
校正：CD109通过稳定IL-6受体-α和激活STAT3/NRF2途径驱动鳞状细胞癌细胞的致瘤性和抗氧化状态(IL-6介导)
Amani Hassan,Tenzin Kungyal,Shufeng Zhou et al.
Amani Hassan et al.
Published Erratum
Experimental hematology & oncology. 2025 May 31;14(1):81. DOI:10.1186/s40164-025-00671-2 2025
Exploring neutrophil extracellular traps: mechanisms of immune regulation and future therapeutic potential [0.03%]
探究中性粒细胞胞外陷阱的免疫调节机制及其未来治疗潜力
Fan Gao,Hongwei Peng,Ruixue Gou et al.
Fan Gao et al.
Neutrophil extracellular traps (NETs) are complex, web-like structures consisting of DNA intertwined with antimicrobial proteins, which neutrophils release upon immune activation. These structures play a crucial role in pathogen elimination...
Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRASG12D-mutated pancreatic cancer [0.03%]
靶向DNA解旋酶CMG复合物和NFκB2驱动的耐药转录轴有效治疗KRASG12D突变型胰腺癌
Jeffrey Xiao,Joshua Kim,Brandon Park et al.
Jeffrey Xiao et al.
Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a 5-year overall survival (OS) rate of approximately 12%. More than 90% of PDAC patients harbor oncogenic mutations in the Kirsten rat sarcoma viral homolog (KRAS) gen...
MENIN inhibitor-based therapy in acute leukemia: latest updates from the 2024 ASH annual meeting [0.03%]
2024年ASH年会急性白血病Menin抑制剂治疗最新进展
Jiewen Sun,Wenjuan Yu,Xiang Zhang
Jiewen Sun
Menin inhibitors (MENINis) represent a novel and promising class of therapeutic agents for acute leukemia (AL). AL subtypes driven by overexpressed HOXA9/MEIS1, such as those characterized by KMT2A-rearranged (KMT2Ar) or NPM1-mutated (NPM1m...
Ran Ran,Xi Chen,Jin Yang et al.
Ran Ran et al.
Breast cancer remains one of the most prevalent malignancies worldwide, underscoring an urgent need for innovative therapeutic strategies. Immunotherapy has emerged as a transformative frontier in this context. In triple-negative breast can...
Developments in nanotechnology approaches for the treatment of solid tumors [0.03%]
纳米技术在固体肿瘤治疗中的研究进展
Jacopo Venturini,Abhijit Chakraborty,Mehmet A Baysal et al.
Jacopo Venturini et al.
Nanotechnology has revolutionized cancer therapy by introducing advanced drug delivery systems that enhance therapeutic efficacy while reducing adverse effects. By leveraging various nanoparticle platforms-including liposomes, polymeric nan...
Next-generation immunotherapeutic approaches for blood cancers: Exploring the efficacy of CAR-T and cancer vaccines [0.03%]
下一代治疗血液癌症的免疫治疗手段：CAR-T和癌症疫苗的有效性探讨
Kiavash Hushmandi,Abbas Ali Imani Fooladi,Russel J Reiter et al.
Kiavash Hushmandi et al.
Recent advancements in immunotherapy, particularly Chimeric antigen receptor (CAR)-T cell therapy and cancer vaccines, have significantly transformed the treatment landscape for leukemia. CAR-T cell therapy, initially promising in hematolog...
Unravelling neutropenic enterocolitis: insights from gut microbiota, and intestinal barrier analyses [0.03%]
脓毒症相关性肠炎发病机制的研究进展：来自肠道菌群和肠屏障研究的见解
Natacha Kapandji,Maud Salmona,Anaïs Lemoine et al.
Natacha Kapandji et al.
Background: Neutropenic enterocolitis (NE) is a severe digestive complication of chemotherapy, primarily affecting patients with acute myeloid leukemia (AML). We hypothesized that NE is linked to intestinal barrier dysfun...