MENIN inhibitor-based therapy in acute leukemia: latest updates from the 2024 ASH annual meeting [0.03%]
2024年ASH年会急性白血病Menin抑制剂治疗最新进展
Jiewen Sun,Wenjuan Yu,Xiang Zhang
Jiewen Sun
Menin inhibitors (MENINis) represent a novel and promising class of therapeutic agents for acute leukemia (AL). AL subtypes driven by overexpressed HOXA9/MEIS1, such as those characterized by KMT2A-rearranged (KMT2Ar) or NPM1-mutated (NPM1m...
Ran Ran,Xi Chen,Jin Yang et al.
Ran Ran et al.
Breast cancer remains one of the most prevalent malignancies worldwide, underscoring an urgent need for innovative therapeutic strategies. Immunotherapy has emerged as a transformative frontier in this context. In triple-negative breast can...
Developments in nanotechnology approaches for the treatment of solid tumors [0.03%]
纳米技术在固体肿瘤治疗中的研究进展
Jacopo Venturini,Abhijit Chakraborty,Mehmet A Baysal et al.
Jacopo Venturini et al.
Nanotechnology has revolutionized cancer therapy by introducing advanced drug delivery systems that enhance therapeutic efficacy while reducing adverse effects. By leveraging various nanoparticle platforms-including liposomes, polymeric nan...
Next-generation immunotherapeutic approaches for blood cancers: Exploring the efficacy of CAR-T and cancer vaccines [0.03%]
下一代治疗血液癌症的免疫治疗手段：CAR-T和癌症疫苗的有效性探讨
Kiavash Hushmandi,Abbas Ali Imani Fooladi,Russel J Reiter et al.
Kiavash Hushmandi et al.
Recent advancements in immunotherapy, particularly Chimeric antigen receptor (CAR)-T cell therapy and cancer vaccines, have significantly transformed the treatment landscape for leukemia. CAR-T cell therapy, initially promising in hematolog...
Unravelling neutropenic enterocolitis: insights from gut microbiota, and intestinal barrier analyses [0.03%]
脓毒症相关性肠炎发病机制的研究进展：来自肠道菌群和肠屏障研究的见解
Natacha Kapandji,Maud Salmona,Anaïs Lemoine et al.
Natacha Kapandji et al.
Background: Neutropenic enterocolitis (NE) is a severe digestive complication of chemotherapy, primarily affecting patients with acute myeloid leukemia (AML). We hypothesized that NE is linked to intestinal barrier dysfun...
A correlation of ineffective erythropoiesis and dysregulated signaling pathways in myelodysplastic syndromes/neoplasms [0.03%]
低效红细胞生成及信号转导通路异常在骨髓增生异常综合症/肿瘤中的相关性研究
Junying Wu,Jinqin Liu,Jia Chen et al.
Junying Wu et al.
Over 90% of patients with myelodysplastic syndromes/neoplasms (MDS) exhibit anemia at diagnosis, primarily due to ineffective erythropoiesis. This is characterized by abnormal proliferation and differentiation of erythroid cells influenced ...
Epstein-Barr virus infection following allogeneic hematopoietic stem cell transplantation in the era of letermovir for cytomegalovirus prophylaxis [0.03%]
雷特姆韦预防巨细胞病毒时代allo-HSCT后EB病毒感染
Jingtao Huang,Jing Zhou,Shixuan Zhang et al.
Jingtao Huang et al.
Letermovir is an antiviral agent that significantly decreases the frequency of cytomegalovirus (CMV) infections following allogeneic hematopoietic stem cell transplantation (allo-HCT); however, its impact on Epstein-Barr virus (EBV) infecti...
Impact of diagnosis to treatment interval on outcomes in patients with newly diagnosed marginal zone lymphoma - a US multisite study [0.03%]
美国多中心新诊断的边缘区淋巴瘤患者的诊断至治疗间隔对预后的影响研究
Narendranath Epperla,Geoffrey Shouse,Natalie S Grover et al.
Narendranath Epperla et al.
Diagnosis-to-treatment interval (DTI) is an important prognostic factor in patients with newly diagnosed aggressive lymphomas, however the impact of DTI on outcomes in marginal zone lymphoma (MZL) is unknown. In this multicenter retrospecti...
Superiority of targeted RNA sequencing for fusion detection and subtype diagnosis in Chinese sarcoma patients: a multicenter study [0.03%]
针对RNA测序在肉瘤融合检测和亚型诊断中优势的多中心研究
Gu Jin,Dandan Zhao,Baoming Wang et al.
Gu Jin et al.
Sarcomas are rare, heterogeneous mesenchymal malignancies with notably high misdiagnosis rates. Despite sarcoma patients in China representing about one-quarter of the global disease burden, large-scale NGS-based diagnostic studies remain s...
Molecular mechanisms of viral oncogenesis in haematological malignancies: perspectives from metabolic reprogramming, epigenetic regulation and immune microenvironment remodeling [0.03%]
血液系统恶性肿瘤中病毒致癌的分子机制：代谢重编程、表观遗传调控和免疫微环境重塑的新视角
Qing Xiao,Yi Liu,Xuejiao Shu et al.
Qing Xiao et al.
Haematological malignancies are one of the most common tumors, with a rising incidence noted over recent decades. Viral infections play significant roles in the pathogenesis of these malignancies globally. This review delves into the contri...