Overall survival of recurrent/metastatic head & neck squamous cell carcinoma patients progressing after ≥ 1 line of systemic therapy, treated with MVX-ONCO-1, a novel, first in class cell encapsulation-based immunotherapy: results of SAKK 11/16, a phase IIa trial [0.03%]
MVX-ONCO-1治疗复发/转移性头颈部鳞状细胞癌患者（至少一线系统治疗后进展）的总生存期：SAKK 11/16二期a阶段试验结果，一种新型首创新药，基于细胞封装的免疫疗法
Eugenio Fernandez,Rémi Vernet,Muriel Urwyler et al.
Eugenio Fernandez et al.
Background: Over the past two decades, most cancer vaccines have failed to be developed clinically. The lack of efficient priming with specific tumor antigens and/or weak adjuvants may explain this poor success rate. MVX-...
IL-7-PD-L1 nano-antibody mediated "zipper" effect augments the tumoricidal activity of tumor-infiltrating lymphocytes [0.03%]
白细胞介素7程序性死亡配体1纳米抗体介导的“拉链”效应增强肿瘤浸润淋巴细胞的杀瘤活性
Zhongjie Yu,Zhen Guo,Bin Jiang et al.
Zhongjie Yu et al.
Cancer represents a pressing global health concern, characterized by a substantial number of unmet clinical needs. Cell therapy has emerged as a promising and efficacious approach for cancer treatment, particularly tumor-infiltrating lympho...
Extracellular matrix stiffness reduces DNA 6 ma level to facilitate colorectal cancer progression via disrupting P53 binding to CDKN1A promoter [0.03%]
细胞外基质刚度通过破坏P53与CDKN1A启动子的结合降低DNA 6mA水平以促进结直肠癌进展
Si-An Xie,Xue Li,Min-Yue Yin et al.
Si-An Xie et al.
The extracellular matrix (ECM) forms the primary scaffold of the tumor microenvironment, with matrix stiffness serving as a critical physical cue that modulates cancer progression. However, the impact of matrix stiffness on colorectal cance...
Improving CAR-T cell function through a targeted cytokine delivery system utilizing car target-modified extracellular vesicles [0.03%]
利用car靶向修饰的细胞外囊泡的靶向细胞因子递送系统改善car-t细胞功能
Yuanyuan Zhang,Meijuan Huang,Shujia Zhang et al.
Yuanyuan Zhang et al.
Chimeric antigen receptor (CAR)-T-cell therapy has achieved remarkable clinical success in the treatment of B-cell malignancies; however, its efficacy can be limited by poor T-cell persistence and insufficient antitumor activity in certain ...
The anticancer thiosemicarbazone triapine exerts immune-enhancing activities via immunogenic cell death induction and FAS upregulation [0.03%]
三氮唑羧酰胺类抗肿瘤药物Triapine通过诱导免疫源性细胞死亡和上调FAS发挥增强免疫力的作用
Bianca Stiller,Alessia Stefanelli,Hemma Schueffl et al.
Bianca Stiller et al.
The anticancer thiosemicarbazone Triapine is currently in a phase III clinical trial in combination with radiation therapy and cisplatin. Noteworthy, while radiotherapy induces an immune-activating cell death, so called immunogenic cell dea...
Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition [0.03%]
通过抑制骨硬化蛋白来治愈多发性骨髓瘤的溶骨病灶并恢复骨骼健康
Hayley M Sabol,Aric Anloague,Japneet Kaur et al.
Hayley M Sabol et al.
Background: Multiple myeloma (MM) is associated with a debilitating bone disease that poses significant therapeutic challenges. MM bone disease is characterized by increased bone resorption and suppression of osteoblasts,...
Elevated TIM3 expression on bone marrow T cells drives immune dysfunction in early relapsed blood cancer after allogeneic hematopoietic stem cell transplantation [0.03%]
移植物抗宿主病早期复发血液肿瘤患者骨髓T细胞上TIM3高表达导致免疫功能障碍
Thi Thuy Duong Pham,Su-Young Choi,Jeong Suk Koh et al.
Thi Thuy Duong Pham et al.
Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the leading cause of treatment failure in patients with hematologic malignancies. To better understand the mechanisms underlying early relapse (ER), we com...
CD47 antibody-armed oncolytic adenovirus promotes chimeric antigen receptor macrophage phagocytosis and antitumor immunity [0.03%]
抗CD47抗体武装的溶瘤腺病毒促进嵌合抗原受体巨噬细胞吞噬及抗肿瘤免疫反应
Zhongbing Qi,Shichuan Hu,Jing Zhao et al.
Zhongbing Qi et al.
Background: Chimeric antigen receptor (CAR)-T cell therapy has shown success in hematologic malignancies but has encountered challenges in solid tumors. Macrophages, being a potentially effective therapeutic target, have ...
In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy [0.03%]
深入探讨与三级淋巴器官结构相关并参与浸润肿瘤基质细胞及其在癌症免疫治疗中的潜在作用
Maedeh Radandish,Niloofar Mashhadi,Amir Hossein Aghayan et al.
Maedeh Radandish et al.
Background and purpose: The tumor microenvironment (TME) is widely acknowledged as a pivotal regulator of cancer progression. However, the dualistic role of tertiary lymphoid structures (TLSs), which serve as critical imm...
An ureido-substituted benzenesulfonamide carbonic anhydrase inhibitor exerts a potent antitumor effect in vitro and in vivo [0.03%]
一种脲取代苯磺酰胺类碳酸酐酶抑制剂对肿瘤具有体内和体外的强力抑制作用
Giorgia Gazzaroli,Camilla Tavani,Serena Filiberti et al.
Giorgia Gazzaroli et al.
Carbonic anhydrase IX (CA IX) is a tumor-specific metallo-enzyme upregulated during hypoxic conditions and implicated in several pathophysiological processes where tissue pH regulation is required such as cancer, cell invasion, metastatic a...