Mitotic MTH1 inhibitor karonudib kills epithelial ovarian cancer independent of platinum sensitivity [0.03%]
MIT抑制剂karonudib杀死卵巢癌细胞独立于铂敏感性
Rachel M Hurley,Jill M Wagner,Arun Kanakkanthara et al.
Rachel M Hurley et al.
The prognosis for women with ovarian cancer (OC) is particularly poor if resistance to platinum compounds, the mainstay of standard-of-care therapy, develops. Inhibitors of the Nudix hydrolase MuT Homolog 1 (MTH1) have previously been shown...
Rohit Thalla,Ryan Mack,Jorgena Kosti-Schwartz et al.
Rohit Thalla et al.
Myelodysplastic syndromes (MDS) is a heterogeneous group of pre-leukemic diseases characterized by peripheral blood cytopenia, morphologic dysplasia, and an increased risk of transformation to leukemia. MDS develop from genetically mutant c...
Homologous recombination-DNA damage response defects increase TMB and neoantigen load, but not effector T cell density and clonal diversity in pancreatic cancer [0.03%]
同源重组-DNA损伤反应缺陷增加胰腺癌的TMB和新生抗原负荷，但不会增加效应T细胞密度和克隆多样性
Mengyue Lei,Jessica Gai,Thomas J McPhaul et al.
Mengyue Lei et al.
Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to chemotherapy. However, PDAC with germline BRCA mutations, which lead to homologous recombination (HR) deficiency (HRD), demonstrated an increased sensitivity to platinum-based c...
Multi-omics analyses of the heterogenous immune microenvironment in triple-negative breast cancer implicate UQCRFS1 potentiates tumor progression [0.03%]
多组学分析揭示三阴性乳腺癌异质性免疫微环境中的UQCRFS1促进肿瘤进展
Yuhui Tang,Aiqi Xu,Zhongbiao Xu et al.
Yuhui Tang et al.
Background: Triple-negative breast cancer (TNBC) is commonly characterized by high-grade and aggressive features, resulting in an augmented likelihood of distant metastasis and inferior prognosis for patients. Tumor immun...
Correction: Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma [0.03%]
题目改正：赖氨酸特异性脱甲基酶1抑制作用增强蛋白酶体抑制剂的抑瘤作用并克服骨髓瘤的耐药性
Cecilia Bandini,Elisabetta Mereu,Tina Paradzik et al.
Cecilia Bandini et al.
Published Erratum
Experimental hematology & oncology. 2025 Jun 13;14(1):82. DOI:10.1186/s40164-025-00675-y 2025
Platelets in cancer and immunotherapy: functional dynamics and therapeutic opportunities [0.03%]
血小板在癌症和免疫治疗中的功能动态与治疗机会
Changjing Cai,Yiting Liu,Ruohuang Lu et al.
Changjing Cai et al.
Platelets play a critical role in tumor immunity, particularly in promoting cancer progression. Numerous studies suggest that platelets could serve as a novel target for cancer immunotherapy, however, no comprehensive reviews have yet summa...
Comprehensive molecular characterization of adult H3K27M mutated thalamic glioma long-term survivors [0.03%]
成人H3K27M突变thalamic胶质瘤长期生存者全面分子特征分析
Hao Xu,Xiaomu Hu,Biyun Wang et al.
Hao Xu et al.
H3K27-altered diffuse midline gliomas (H3-DMGs) represent aggressive tumors with fatal outcome and exceedingly rare cases have a long-term survival (LTS). We included 5 adult thalamic H3-DMG LTS and 13 short-term survivors (STS), and perfor...
Correction: IL‑6‑mediated tumorigenicity and antioxidant state in squamous cell carcinoma cells are driven by CD109 via stabilization of IL‑6 receptor‑alpha and activation of STAT3/NRF2 pathway [0.03%]
校正：CD109通过稳定IL-6受体-α和激活STAT3/NRF2途径驱动鳞状细胞癌细胞的致瘤性和抗氧化状态(IL-6介导)
Amani Hassan,Tenzin Kungyal,Shufeng Zhou et al.
Amani Hassan et al.
Published Erratum
Experimental hematology & oncology. 2025 May 31;14(1):81. DOI:10.1186/s40164-025-00671-2 2025
Exploring neutrophil extracellular traps: mechanisms of immune regulation and future therapeutic potential [0.03%]
探究中性粒细胞胞外陷阱的免疫调节机制及其未来治疗潜力
Fan Gao,Hongwei Peng,Ruixue Gou et al.
Fan Gao et al.
Neutrophil extracellular traps (NETs) are complex, web-like structures consisting of DNA intertwined with antimicrobial proteins, which neutrophils release upon immune activation. These structures play a crucial role in pathogen elimination...
Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRASG12D-mutated pancreatic cancer [0.03%]
靶向DNA解旋酶CMG复合物和NFκB2驱动的耐药转录轴有效治疗KRASG12D突变型胰腺癌
Jeffrey Xiao,Joshua Kim,Brandon Park et al.
Jeffrey Xiao et al.
Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a 5-year overall survival (OS) rate of approximately 12%. More than 90% of PDAC patients harbor oncogenic mutations in the Kirsten rat sarcoma viral homolog (KRAS) gen...