Tumor-associated mesenchymal stem/stromal cells in tumor microenvironment and carcinogenesis [0.03%]
肿瘤微环境中的肿瘤相关间充质干细胞/基质细胞及其致癌作用
Li Sun,Xiaoli Cao,Baocheng Zhou et al.
Li Sun et al.
Mesenchymal stem/stromal cells (MSCs) possess significant potential in regenerative medicine, attributed to their inherent capacity for site-specific homing to inflammatory regions, diverse differentiation abilities, and immunomodulatory fu...
Global burden and trends of hematologic malignancies based on Global Cancer Observatory 2022 and Global Burden of Disease 2021 [0.03%]
基于全球癌症观察站（2022年）和疾病负担（2021年）的全球血液系统恶性肿瘤的疾病负担及趋势分析
Tao Pan,Jiyue Zhang,Xiaomin Wang et al.
Tao Pan et al.
Background: Hematologic malignancies are one of the most common types of cancer. This study aims to assess the global burden of hematologic malignancies and analyze the global epidemiological trends. ...
Advancing precision antibody-drug conjugate therapy: unique proteogenomic profiles of tumor subsets in non-small cell lung cancer [0.03%]
抗体偶联药物精准治疗的进展：非小细胞肺癌亚型肿瘤的蛋白基因组特征分析
Edwin Lin,Ying-Chun Lo,Vivek Subbiah et al.
Edwin Lin et al.
Antibody-drug conjugates (ADCs) represent a promising therapeutic strategy for non-small cell lung cancer (NSCLC), targeting tumor-specific antigens with precision. However, the molecular heterogeneity of NSCLC necessitates multiplex biomar...
Reduced morbidity and mortality of cGVHD in patients who received treatment with mesenchymal stromal cells for steroid-resistant aGVHD: long-term follow-up of a randomized phase 3 trial [0.03%]
间充质基质细胞治疗激素抵抗性急性移植物抗宿主病的长期随访研究：随机三期临床试验结果显示慢性移植物抗宿主病发生率和死亡率降低
Ke Zhao,Ren Lin,Zhiping Fan et al.
Ke Zhao et al.
Background: Our open-label, multicenter, randomized, phase 3 trial showed that the incidence and severity of chronic graft-versus-host disease (cGVHD) reduced in steroid-resistant acute graft-versus-host disease (aGVHD) p...
iPSC-derived NK cells engineered with CD226 effectively control acute myeloid leukemia [0.03%]
通过CD226工程改造的诱导多能干细胞来源的NK细胞有效控制急性髓系白血病
Runze Cai,Binyan Lu,Xiangyu Zhao et al.
Runze Cai et al.
CD226 plays a vital role in NK cell cytotoxicity, interacting with its ligands on tumor targets. Acute myeloid leukemia (AML) cells have developed mechanisms to escape NK cell cytotoxicity, including inducing downregulation of CD226 on NK c...
Recent advances and challenges of cellular immunotherapies in lung cancer treatment [0.03%]
肺癌治疗中细胞免疫疗法的新进展和挑战
Chengfei Yang,Yue Liu,Ziqi Huang et al.
Chengfei Yang et al.
Lung cancer is a major malignant tumor with high morbidity and fatality rates. For many years, traditional treatments for lung cancer have struggled to achieve a favorable outlook and prognosis. It is crucial to identify and innovate novel ...
Bladder cancer subtypes exhibit limited plasticity across different microenvironments and in metastases [0.03%]
膀胱癌亚型在不同微环境和转移灶中表现出有限的可塑性
Carina Bernardo,Subhayan Chattopadhyay,Natalie Andersson et al.
Carina Bernardo et al.
Background: Transcriptomic and genomic analyses of bladder cancer (BC) reveal a highly diverse disease stratified into molecular subtypes with distinct molecular features and biological behaviors. Intratumor heterogeneity...
Prophylactic infusion of allogeneic double-negative T cells as immune modulators to prevent relapse in high-risk AML patients post-Allo-HSCT: a phase I trial [0.03%]
allo-DN-T细胞预防高危AML患者移植后复发的I期临床研究
Guangyu Sun,Xingchi Chen,Tianzhong Pan et al.
Guangyu Sun et al.
Relapse remains a major challenge for high-risk acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem cell transplantation (allo-HSCT). In our first-in-human Phase I trial (ChiCTR-1900022795), we have demonstrated th...
Current challenges and emerging opportunities of chimeric antigen receptor-engineered cell immunotherapy [0.03%]
嵌合抗原受体工程细胞免疫治疗的现状、挑战与机遇
Yong Liu,Yifei Duan,Zefan Du et al.
Yong Liu et al.
Chimeric antigen receptor (CAR) engineered cellular immunotherapy offers the potential for precise targeting and elimination of tumor cells, providing a tailored approach to cancer treatment. CAR-T cells demonstrate significant anti-tumor a...
High cereblon expression in neuroendocrine cancer confers vulnerability to GSPT1 molecular glue degrader [0.03%]
神经内分泌癌中高表达的 cereblon 使其对 GSPT1 分子胶降解剂更易感
Jaewoo Park,Min Sung Joo,Myung Jun Kim et al.
Jaewoo Park et al.
Background: Recent advances in targeted therapies have introduced molecular glue degraders (MGDs) that leverage the cereblon (CRBN) E3 ubiquitin ligase to degrade the translation termination factor GSPT1. Understanding th...