Hepatitis C Virus Direct-Acting Antiviral Drug Interactions and Use in Renal and Hepatic Impairment [0.03%]
丙型肝炎病毒直接抗病毒药物的相互作用及其在肾功能不全和肝功能不全中的应用
Lucas Hill
Lucas Hill
Direct-acting antiviral (DAA) drugs exhibit considerable variability in mechanisms of metabolism and the extent to which they are substrates, inhibitors, or inducers of cytochrome P450 enzymes or P-glycoprotein and other drug transporters. ...
Preexposure Prophylaxis For HIV Prevention: What We Know and What We Still Need to Know for Implementation [0.03%]
HIV预防的暴露前预防：我们所了解的情况以及在实现暴露前预防过程中仍需了解的问题
Raphael J Landovitz
Raphael J Landovitz
Preexposure prophylaxis (PrEP) with tenofovir and emtricitabine has been shown to be effective and cost-effective in preventing acquisition of HIV infection. However, PrEP has not yet been widely adopted in the clinical practice setting. Da...
Jintanat Ananworanich
Jintanat Ananworanich
Investigational strategies to attempt HIV cure or remission include very early initiation of antiretroviral therapy to limit the latent HIV reservoir and preinfection vaccination. In the setting of viral suppression, strategies include reac...
Anne F Luetkemeyer,David L Wyles
Anne F Luetkemeyer
High cure rates with all-oral regimens for patients with HIV/hepatitis C virus (HCV) coinfection were a highlight of the 2015 Conference on Retroviruses and Opportunistic Infections. Twelve weeks of sofosbuvir and daclatasvir led to sustain...
CROI 2015: Complications of HIV Infection and Antiretroviral Therapy [0.03%]
CROI 2015：HIV感染及抗逆转录病毒治疗的并发症
Diane V Havlir,Judith S Currier
Diane V Havlir
Noncommunicable diseases, such as cardiovascular disease, hypertension, renal and bone disease, and malignancies are an ongoing concern during the course of treated HIV disease. Research in this area continues to focus on the epidemiology a...
Serena S Spudich,Beau M Ances
Serena S Spudich
More than 30 years into the HIV epidemic, research efforts are focusing on better understanding how the central nervous system (CNS) is adversely affected by HIV and on improving the quality of life of HIV-infected individuals. At the 2015 ...
Susan A Olender,Barbara S Taylor,Marcia Wong et al.
Susan A Olender et al.
The 2015 Conference on Retroviruses and Opportunistic Infections included new and exciting advances in the realm of antiretroviral therapy. The Temprano trial demonstrated benefits from early antiretroviral therapy and isoniazid preventive ...
Susan P Buchbinder,Albert Y Liu
Susan P Buchbinder
HIV testing rates and awareness of HIV serostatus have improved globally, but disparities continue between black and white men who have sex with men (MSM) in the United States, and between women and men globally. The 2015 Conference on Retr...
Mario Stevenson
Mario Stevenson
The 2015 Conference on Retroviruses and Opportunistic Infections (CROI) represents a forum that encompasses all facets of research on HIV/AIDS and its complications. CROI is a valuable venue for scientific and public health researchers, cli...
Carlos Del Rio
Carlos Del Rio
Recommendations for HIV prevention in clinical care settings by an IAS-USA panel were recently published. They include recommendations on HIV testing, antiretroviral therapy initiation, risk-reduction counseling, and antiretroviral therapy ...