Christina Wang,Mario P R Festin,Ronald S Swerdloff
Christina Wang
Hormonal male contraception clinical trials began in the 1970s. The method is based on the use of exogenous testosterone alone or in combination with a progestin to suppress the endogenous production of testosterone and spermatogenesis. Stu...
Lucy Liu,Abraham Segura,Andrea R Hagemann
Lucy Liu
Obesity is the cause of up to one-third of all cancers affecting women today, most notably endometrial, colon and breast cancer. Women's health providers are poised to advise women on obesity's link to cancer development, but often lack res...
The Impact of Diabetes on Gynecologic Cancer: Current Status and Future Directions [0.03%]
糖尿病对妇科肿瘤影响的研究现状与未来方向
Brittany Lees,Charles A Leath rd
Brittany Lees
Diabetes mellitus has reached epidemic proportions in both the United States and worldwide with most authorities reporting a doubling in the prevalence of diabetes over the last 20-30 years. While this epidemic is closely tied to obesity, d...
Gretchen L Gierach,Xiaohong R Yang,Jonine D Figueroa et al.
Gretchen L Gierach et al.
Developing improved methods for breast cancer risk prediction could facilitate the targeting of interventions to women at highest risk, thereby reducing mortality, while sparing low-risk women the costs and inconvenience of unnecessary test...
An Evidence-Based Approach to the Evaluation, Diagnostic Assessment and Treatment of Fecal Incontinence in Women [0.03%]
基于证据的女性粪失禁评估、诊断及治疗指南
Isuzu Meyer,Holly E Richter
Isuzu Meyer
Fecal incontinence (FI) is a debilitating disorder which negatively impacts quality of life. The etiology is often multifactorial and although most women with FI are able to be treated, many remain untreated because a significant proportion...
Fertility Preservation for Prepubertal Girls: Update and Current Challenges [0.03%]
青春期前女孩的生育力保存：更新及当前挑战
Nina Resetkova,Masanori Hayashi,Lisa A Kolp et al.
Nina Resetkova et al.
With increasing rates of diagnosis of childhood cancers and the evolution of more effective treatment options resulting in prolonged life spans, fertility preservation counseling is an integral component of the discussion at the time of dia...
The Role of Endocrine Disruptors in the Epigenetics of Reproductive Disease and Dysfunction: Potential Relevance to Humans [0.03%]
内分泌干扰物在生殖疾病和功能障碍的表观遗传学中的作用：对人类的潜在相关性
Kaylon L Bruner-Tran,David Resuehr,Tianbing Ding et al.
Kaylon L Bruner-Tran et al.
In a murine model, we have linked early life toxicant exposure to reduced uterine sensitivity to progesterone, a phenotype we had previously associated with inflammation in endometriosis patients. Subsequent studies revealed that developmen...
Cervical Cancer: Development of Targeted Therapies Beyond Molecular Pathogenesis [0.03%]
宫颈癌：超越分子发病机制的靶向治疗的发展
Jayne Knoff,Benjamin Yang,Chien-Fu Hung et al.
Jayne Knoff et al.
It is well known that human papillomavirus (HPV) is the causative agent of cervical cancer. The integration of HPV genes into the host genome causes the upregulation of E6 and E7 oncogenes. E6 and E7 proteins inactivate and degrade tumor su...
Management of Chemoresistant and Quiescent Gestational Trophoblastic Disease [0.03%]
化疗耐药和静止型妊娠滋养细胞疾病的管理
Siew-Fei Ngu,Karen K L Chan
Siew-Fei Ngu
Gestational trophoblastic neoplasia (GTN) is highly chemosensitive and has a high cure rate. Since the introduction of chemotherapy, reliable measurement of human chorionic gonadotropin (hCG) levels, and individualised risk-based therapy in...
Genetics and Epigenetics of Recurrent Hydatidiform Moles: Basic Science and Genetic Counselling [0.03%]
复发性葡萄胎的遗传及表观遗传学：基础科学与遗传咨询
Ngoc Minh Phuong Nguyen,Rima Slim
Ngoc Minh Phuong Nguyen
Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal hyperproliferation of trophoblastic cells, which derive from the trophectoderm, the outer layer of the blastocyst that would normally develop ...