Pharmacokinetics, Bioequivalence, and Safety of Levothyroxine Sodium Tablets in Healthy Chinese Subjects [0.03%]
硫酸左甲状腺素片在中国健康受试者体内的药代动力学、生物等效性及安全性试验
Juan Jin,Chunrong Huang,Fangliang Gan et al.
Juan Jin et al.
Recently, a local pharmaceutical company produced levothyroxine sodium tablets, an endogenous drug that helps improve water-salt metabolism and reduce myxedema. However, the bioequivalence of these tablets is not well known. The present stu...
Population Pharmacokinetic and Exposure-Response Analysis of the Cognitive Effects of TAK-071 in Participants With Parkinson Disease and Cognitive Impairment [0.03%]
帕金森病合并认知障碍患者中TAK-071药代动力学和暴露反应关系分析
Hongxia Jia,Axel Facius,Rachel Jennings et al.
Hongxia Jia et al.
TAK-071 is a novel muscarinic M1 positive allosteric modulator under investigation for the treatment of cognitive impairment and falls associated with Parkinson disease (PD). This study evaluated population pharmacokinetics of TAK-071 follo...
Comparative Pharmacodynamic Bioequivalence Study of Enoxaparin Sodium 100 mg/1 mL Solution for Injection in Prefilled Syringe in Healthy Volunteers Under Fasting Conditions [0.03%]
空腹状态下依诺肝素钠注射液（100mg/1mL）预灌封注射器与原研产品在中国健康人群中的药动学生物等效性研究
Naba Kumar Talukdar,Shailesh Sonar,Nisha Pal et al.
Naba Kumar Talukdar et al.
This study evaluated the bioequivalence of enoxaparin sodium 100 mg/1 mL solution for injection in a prefilled syringe manufactured by a generic company was compared with the reference product of the same dosage form, in healthy adult volun...
Pharmacokinetics, Safety, and Tolerability of Different Maintenance Dose Regimens of Mosnodenvir (JNJ-1802) in Healthy Adult Participants [0.03%]
莫努匹韦在健康成人受试者中的不同维持剂量方案的药代动力学、安全性和耐受性
Thomas N Kakuda,Nicole Harasym,Annemie Buelens et al.
Thomas N Kakuda et al.
Dengue virus infection has become a global health concern, and no dengue-specific treatment is available. Mosnodenvir is a pan-serotypic dengue antiviral in clinical development. In this Phase 1, open-label study (NCT05201937), high- and lo...
Pharmacokinetic and Bioequivalence Evaluation of Two Sitagliptin Tablets With Different Salts in Healthy Subjects [0.03%]
两种不同盐酸盐二甲双胍片在健康受试者中的药代动力学和生物等效性评价
Usok Hyun,Seongnam Chu,Sungyun Kim et al.
Usok Hyun et al.
The objective of the current study was to evaluate the rate and extent of absorption of a test formulation (sitagliptin hydrochloride) and a reference formulation (sitagliptin phosphate). An open-label, randomized, single-dose, single-cente...
Physiologically Based Pharmacokinetic Modeling to Evaluate Drug-Drug Interactions of Tacrolimus With Ritonavir, a CYP3A Irreversible Inhibitor: Applications for Dosing Optimization in Transplant Patients [0.03%]
生理药动学模型在评估环孢素与不可逆CYP3A抑制剂洛匹那韦药物相互作用中的应用：器官移植患者的给药优化研究
Yanjun Jiang,Lu Wang,Jia Liu et al.
Yanjun Jiang et al.
Immunosuppressant tacrolimus is frequently coadministered with other drugs in clinical practice. Ritonavir is a CYP3A irreversible inhibitor that is used in combination with nirmatrelvir for the treatment of COVID-19 in nirmatrelvir/ritonav...
Strategies to Manage Dosing Deviations and Interruptions of Cabotegravir Long-Acting Intramuscular Injections [0.03%]
卡博特格拉韦长效肌肉注射给药偏差和用药中断的管理策略
Kelong Han,Ronald D D&#x;Amico,William R Spreen et al.
Kelong Han et al.
Long-acting cabotegravir is approved for HIV treatment and prevention. To guide management of dosing deviations and interruptions, concentration-time profiles for monthly and every 2 months regimens were simulated using a population pharmac...
Pharmacokinetics and Safety of Armodafinil in Chinese Healthy Humans After Multiple-Dose Oral Administration [0.03%]
阿莫达非尼在健康中国人体内多次口服给药后的药代动力学和安全性研究
Liwei Lang,Yuan Dong,Zhenzhen Zhu et al.
Liwei Lang et al.
Armodafinil, the R-enantiomer of modafinil that promotes wakefulness, was studied regarding its pharmacokinetics and safety in healthy Chinese subjects after multiple-dose oral administration (200 mg daily for 7 days). Twelve subjects parti...
A Double-Blind, Placebo-Controlled, Single-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT-101, an RNAi Therapeutic Targeting HBV Infection [0.03%]
一项评估HBV感染治疗药物HT-101（一种RNAi疗法）的安全性、耐受性和药代动力学的单次递增剂量的双盲安慰剂对照研究
Jianxiong Zhang,Jiangshuo Li,Le Wu et al.
Jianxiong Zhang et al.
HT-101, a liver-targeted N-acetylgalactosamine-conjugated ribonucleic acid interference therapeutic, exhibits promising potential for the treatment of chronic hepatitis B virus infection. This randomized, double-blind, placebo-controlled, a...
Pharmacokinetics and Bioequivalence Evaluation of Two Different Aildenafil Citrate Tablet Formulations in Healthy Chinese Male Subjects Under Fasting and Fed Conditions [0.03%]
空腹及餐后条件下两种不同制剂的他达拉非片在中国健康男性受试者体内的药代动力学及生物等效性评价
Hegui Yan,Yu Peng,Zhixiang Pan et al.
Hegui Yan et al.
Aildenafil citrate is a novel and potent phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction (ED). This study evaluates the pharmacokinetics and bioequivalence of 2 formulations of aildenafil citrate tablets (30 and...