The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease [0.03%]
BNC210作为一种阿尔法-7烟碱乙酰胆碱受体(NACC)拮抗剂治疗精神疾病的实验验证路径研究
Paul Rolan,Elizabeth Doolin,Dharam Paul et al.
Paul Rolan et al.
BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha-7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical ...
A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG-055009, a novel thyroid hormone receptor beta (THR-β) agonist for metabolic dysfunction-associated steatohepatitis (MASH), in healthy participants [0.03%]
ALG-055009的I期多部分研究：这是一种新型甲状腺激素受体β（THR-β）激动剂，用于代谢功能障碍相关肝硬化（MASH），该研究评估了健康参与者中的安全性、药理动力学和药代动力学
Hakim Charfi,Benedetta Massetto,Megan Fitzgerald et al.
Hakim Charfi et al.
ALG-055009 is an oral thyroid hormone receptor beta (THR-β) agonist being evaluated for treating metabolic dysfunction-associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics...
Safety, Tolerability, and Pharmacokinetics of Galcanezumab, an Anti-CGRP Antibody, in Healthy Chinese Participants [0.03%]
关于抗CGRP抗体Galcanezumab在健康受试者中的安全性、耐受性和药代动力学研究
Jingjing Wang,Nanyang Li,Jinjie He et al.
Jingjing Wang et al.
Galcanezumab is used in several regions, including the United States, Europe, and China, as a preventive treatment for migraine. This study aimed to evaluate the safety, tolerability, and pharmacokinetics (PK) of galcanezumab in healthy Chi...
Pharmacokinetics, Tolerability, and Biomarker Profile of the Neurokinin 3 Receptor Antagonist Fezolinetant in Healthy Japanese Individuals: A 2-Part, Randomized, Phase 1 Study [0.03%]
一项随机Ⅰ期研究：fezolinetant在健康日本受试者中的药代动力学、耐受性及生物标志物特征的两部分研究
Akira Koibuchi,Megumi Iwai,Kanji Komatsu et al.
Akira Koibuchi et al.
This 2-part, randomized, placebo-controlled, double-blind, Phase 1 study analyzed the pharmacokinetics, safety, and biomarker profile of fezolinetant in healthy Japanese individuals. Part 1: male participants received single doses of placeb...
Pharmacokinetics and bioequivalence of acetylcysteine granules among Chinese healthy volunteers under fasting and postprandial conditions [0.03%]
乙酰半胱氨酸颗粒在空腹及餐后条件下健康受试者药代动力学及生物等效性研究
Jingjing Wang,Wanggang Zhang
Jingjing Wang
This study aimed to evaluate the pharmacokinetics, bioequivalence, and safety for two formulations of acetylcysteine granules in healthy Chinese subjects under fasting and postprandial conditions. A single-center, randomized, open-label, si...
Comparison of the Pharmacokinetics of Three Budesonide Formulations in Healthy Chinese Subjects [0.03%]
三种布地奈德制剂在健康中国受试者中的药代动力学比较研究
Tengrui Yin,Jing Zou,Mei Tang et al.
Tengrui Yin et al.
HR19042 is a novel, orally administered, targeted-release formulation of the topically active corticosteroid budesonide, developed to release active drug within the terminal ileum and indicated to reduced estimated glomerular filtration rat...
Pharmacokinetics and Bioequivalence of Two Formulations of Valsartan and Amlodipine Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions [0.03%]
valsartan和amlodipine片剂在空腹及餐后健康受试者中的药代动力学及生物等效性研究
Yu-Ying Xu,Wen-Tan Xu,Wei-Ping Pan et al.
Yu-Ying Xu et al.
This study assessed the pharmacokinetics (PK) and bioequivalence (BE) of valsartan and amlodipine (80/5 mg) tablets in healthy Chinese subjects under fasting and fed conditions. A randomized, open-label, four-period crossover trial was cond...
Pharmacokinetic Study and Bioequivalence Evaluation of Two Sustained-Release Tablets of Tamsulosin in Healthy Chinese Subjects Under Fasting and Postprandial Conditions [0.03%]
盐酸坦洛新缓释片在中国健康志愿者中的药代动力学及等效性研究：空腹与餐后条件下
Jie Wang,Fang Yao,Pan Lu et al.
Jie Wang et al.
Tamsulosin is a highly selective α1A adrenergic receptor antagonist that can relax smooth muscles in the urethra, bladder neck, and prostate and improve urinary disorders. It is therefore widely used to treat lower urinary tract symptoms c...
Phenobarbital Bioequivalence in Chinese Population: Considering the Role of Food on Pharmacokinetics [0.03%]
含餐对中国人群苯巴比妥生物等效性的影响研究：药代动力学角度
Wang Xinman,Liu Yuan,Sun Ying et al.
Wang Xinman et al.
Epilepsy is one of the most severe neurological disorders in the world, which might seriously endanger the lives of patients. Phenobarbital is an important medicine clinically used for the treatment of epilepsy, and it is irreplaceable in t...