Mutant SOD1 microglia-generated nitroxidative stress promotes toxicity to human fetal neural stem cell-derived motor neurons through direct damage and noxious interactions with astrocytes [0.03%]
突变SOD1微胶质细胞产生的硝基氧化应激通过直接损伤和有害的星形胶质细胞相互作用促进对源自人胎儿神经干细胞的运动神经元的毒性作用
Jason R Thonhoff,Junling Gao,Tiffany J Dunn et al.
Jason R Thonhoff et al.
Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease. Human neural stem cells (hNSCs) may have the potential to replace lost motor neurons. The therapeutic efficacy of stem cell therapy depends greatly on the survival o...
Kevin D Bunting,Igor Slukvin,Ping Wu et al.
Kevin D Bunting et al.
Prostaglandin E2: a putative potency indicator of the immunosuppressive activity of human mesenchymal stem cells [0.03%]
前列腺素E2：人类间充质干细胞免疫抑制活性的潜在功效指标
Luis A Solchaga,Elizabeth A Zale
Luis A Solchaga
Mesenchymal stem cells (MSCs) are non-hematopoietic, pluripotent cells that give rise to stromal cells in the marrow. MSCs have been shown to be immunosuppressive and have become an attractive therapeutic option for the modulation of undesi...
In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation [0.03%]
人骨髓干细胞体外生成功能性胰岛素产生细胞的研究但长期培养有恶变风险
Dong-Qi Tang,Qiwei Wang,Brant R Burkhardt et al.
Dong-Qi Tang et al.
Efforts involving therapeutic islet cell transplantation have been hampered by limited islet availability and immune rejection. In vitro transdifferentiation of human bone marrow-derived stem (hBMDS) cells into functional insulin-producing ...
Gene expression changes in the MAPK pathway in both Fragile X and Down syndrome human neural progenitor cells [0.03%]
脆性X染色体综合征和唐氏综合症人类神经前体细胞中MAPK通路的基因表达变化
Erin L McMillan,Allison L Kamps,Samuel S Lake et al.
Erin L McMillan et al.
The two most common genetic developmental disorders that cause intellectual disability are Down syndrome (DS) and Fragile X syndrome (FXS). Although the genetics and behavioral hallmarks of these two disorders are distinct, common underlyin...
Mutation of STAT1/3 binding sites in gp130(FXXQ) knock-in mice does not alter hematopoietic stem cell repopulation or self-renewal potential [0.03%]
STAT1/3结合位点的gp130(FXXQ)敲入小鼠的基因突变不会改变造血干细胞的重建或自我更新潜能
Zhengqi Wang,Zizhen Kang,Yi Zhang et al.
Zhengqi Wang et al.
Interleukin (IL)-6 family cytokine signaling through gp130 and signal transducer and activator of transcription (STAT) activation is believed important for early hematopoiesis. To determine whether gp130/STAT1/3 physical interaction is requ...