Reprogramming of bone marrow-derived mesenchymal stem cells into functional insulin-producing cells by chemical regimen [0.03%]
用化学方法将骨髓间充质干细胞重编为有功能的胰岛素产生细胞
Qiwei Wang,Lingling Ye,Hong Liu et al.
Qiwei Wang et al.
Beta-cell transplantation is considered to be the most effective approach to cure type 1 diabetes (T1D). Unfortunately, the scarce availability of donor tissue limits the applicability of this therapy. Recent stem cell research progress sho...
Stem cell-based bone repair [0.03%]
基于干细胞的骨修复
Yurong Fei,Ren-He Xu,Marja M Hurley
Yurong Fei
To accelerate bone repair, one strategy is to deliver the cells that make bone. The current review focuses on stem cell-based bone repair. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can self-renew unlimitedly and...
Ilaria Decimo,Guido Fumagalli,Valeria Berton et al.
Ilaria Decimo et al.
Meninges are a three tissue membrane primarily known as coverings of the brain. More in depth studies on meningeal function and ultrastructure have recently changed the view of meninges as a merely protective membrane. Accurate evaluation o...
Towards high throughput tissue engineering: development of chitosan-calcium phosphate scaffolds for engineering bone tissue from embryonic stem cells [0.03%]
基于壳聚糖-钙磷的胚胎干细胞骨组织工程技术研究与发展高通量组织工程：基于壳聚糖-钙磷的胚胎干细胞骨组织工程技术研究发展高 throughput 组织工程：基于壳聚糖-磷酸钙的干细胞支架用于制造骨组织
Junghyuk Ko,Kathleen Kolehmainen,Farid Ahmed et al.
Junghyuk Ko et al.
Tissue engineering strategies have shown promise for the repair of damaged organs, including bone. One of the major challenges associated with tissue engineering is how to scale up such processes for high throughput manufacturing of biomate...
No factor left behind: generation of transgene-free induced pluripotent stem cells [0.03%]
不留因子：生成无转基因诱导多能干细胞
Mo Li,Juan Carlos Izpisua Belmonte
Mo Li
Induced pluripotent stem cells (iPSCs) hold great potential for regenerative medicine, yet their implementation in the clinic still seems far out of reach due to concerns about their safety. The development of safe and efficient reprogrammi...
Loss of imprinting of IGF2 and the epigenetic progenitor model of cancer [0.03%]
IGF2印迹的丢失与癌症表观遗传型癌前驱模型理论
Mark B Leick,Christopher J Shoff,Erwin C Wang et al.
Mark B Leick et al.
Among the hypotheses discussing cancer formation, the cancer stem cell (CSC) theory is one receiving widespread support. One version of this theory states that changes in otherwise healthy cells can cause formation of tumor- initiating cell...
Intrinsic regulation of adult subventricular zone neural progenitor cells and the effect of brain injury [0.03%]
成人侧脑室下区神经干细胞的内在调控及脑损伤的影响研究
Kathryn S Jones,Bronwen Connor
Kathryn S Jones
Regulation over the generation of adult born neuroblasts and oligodendrocyte precursor cells is governed by a myriad of extracellular signals. These signals must be related into the cell nucleus to regulate cell cycle and cell lineage matur...
Phi Villageois,Brigitte Wdziekonski,Laure-Emmanuelle Zaragosi et al.
Phi Villageois et al.
Adipose tissue is an alternative source of mesenchymal stem cells and human adipose-derived stem cells (ASCs) display an attractive and substantial therapeutic potential when transplanted in animal models. To this end, an understanding of A...
HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells [0.03%]
组蛋白去乙酰化酶HDAC9与精神分裂症相关且特异性表达于分化神经元而非成体神经干细胞中
Bing Lang,Tahani Mohammed A Alrahbeni,David St Clair et al.
Bing Lang et al.
Schizophrenia is a common psychiatric disorder and caused by a combination of environmental, social and genetic factors. Histone deacetylases (HDACs) can translate epigenetic effects to the genome by modifying chromatin structure and gene e...
Heesang Song,Woochul Chang,Byeong-Wook Song et al.
Heesang Song et al.
Mesenchymal stem cells (MSCs) are multipotent, self-renewing cells harboring multi-lineage differentiation potential and immunosuppressive properties that make them an attractive candidate for biological cell-based regenerative medicine. In...