Mesenchymal stem cell and regenerative medicine: regeneration versus immunomodulatory challenges [0.03%]
间充质干细胞和再生医学：再生与免疫调控的挑战
Sujata Law,Samaresh Chaudhuri
Sujata Law
Mesenchymal Stem cells (MSC) are now presented with the opportunities of multifunctional therapeutic approaches. Several reports are in support of their self-renewal, capacity for multipotent differentiation, and immunomodulatory properties...
Joseph D Lamplot,Jiaqiang Qin,Guoxin Nan et al.
Joseph D Lamplot et al.
Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily and play a critical role in skeletal development, bone formation and stem cell differentiation. Disruptions in BMP signaling result in a variety of skeletal and extras...
Applications of skeletal muscle progenitor cells for neuromuscular diseases [0.03%]
骨骼肌前体细胞在神经肌肉疾病中的应用
Tohru Hosoyama,Jonathan Van Dyke,Masatoshi Suzuki
Tohru Hosoyama
Neuromuscular diseases affect skeletal muscle and/or nervous control resulting in direct disruption of skeletal muscle and muscle pathology, or nervous system disruption which indirectly disrupts muscle function. Stem cell-based therapy is ...
Prenatal modulation of breast density and breast stem cells by insulin-like growth factor-1 [0.03%]
胰岛素样生长因子-1对乳腺密度及乳腺干细胞的宫内调节作用
Chien-I Chang,Hoi Pang Low,Li Qiu et al.
Chien-I Chang et al.
Biological determinants of breast density, a strong predictor of human breast cancer risk, are postulated to be influenced by prenatal exposures to mitogens. We investigated the extent to which prenatal exposures to insulin-like growth fact...
Current applications of mesenchymal stem cells for tissue replacement in otolaryngology-head and neck surgery [0.03%]
耳鼻喉-头颈外科中用于组织替代的间充质干细胞的当前应用
Suzanne N King,Summer E Hanson,Peiman Hematti et al.
Suzanne N King et al.
Cellular therapy utilizing adult mesenchymal stromal/stem cells (MSCs) may very well revolutionize the treatment of a variety of head and neck diseases through the restoration of normal structure and function. Transplanting allogeneic or au...
Regulatory pathways associated with bone loss and bone marrow adiposity caused by aging, chemotherapy, glucocorticoid therapy and radiotherapy [0.03%]
与骨质流失和骨髓脂肪浸润有关的衰老、化疗、糖皮质激素治疗及放疗的作用途径
Kristen R Georgiou,Susanta K Hui,Cory J Xian
Kristen R Georgiou
The bone marrow is a complex environment that houses haematopoietic and mesenchymal cell populations and regulates bone turnover throughout life. The high proliferative capacity of these cell populations however, makes them susceptible to d...
Directed differentiation of progenitor cells towards an islet-cell phenotype [0.03%]
谱系祖细胞向胰岛细胞表型的定向分化
Arif Abed,Charlotte Critchlow,Peter R Flatt et al.
Arif Abed et al.
Exogenous insulin administration and oral anti-diabetic drugs are the primary means of treating diabetes. However, tight glycaemic control, with its inherent risk of hypoglycaemia, is required to prevent the microvascular and macrovascular ...
Specification of neural cell fate and regulation of neural stem cell proliferation by microRNAs [0.03%]
微小核糖核酸对神经细胞命运的决定及对神经干细胞增殖的调节作用的规定说明书
Jacqueline T Pham,G Ian Gallicano
Jacqueline T Pham
In the approximately 20 years since microRNAs (miRNAs) were first characterized, they have been shown to play important roles in diverse physiologic functions, particularly those requiring coordinated changes in networks of signaling pathwa...
Experimental model for coadjuvant treatment with mesenchymal stem cells for aortic aneurysm [0.03%]
用于腹主动脉瘤的间充质干细胞辅助治疗的实验模型研究
Luis Riera Del Moral,Carlota Largo Aramburu,José Ramón Ramírez García et al.
Luis Riera Del Moral et al.
Many factors are possibly involved in the inflammatory process which causes the degeneration of the arterial wall in the formation of Abdominal Aortic Aneurysms. During the last years different experimental models have been published to tre...
Successful derivation of EGFP-transgenic embryonic stem cell line from a genetically non-permissive FVB/N mouse [0.03%]
成功从遗传学上难以转染的FVB/N小鼠中获得EGFP转基因胚胎干细胞系
Gurbind Singh,Tulasigeri M Totiger,Polani B Seshagiri
Gurbind Singh
Derivation of embryonic stem (ES)-cell lines from genetically non-permissive mouse strains, such as FVB/N, has been difficult, despite this strain offering advantages for mouse transgenesis for developmental studies. We earlier generated β...