Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues [0.03%]
损伤组织中的人体体细胞通过肌动蛋白细胞骨架获得生成类胚胎样变态反应的可塑性
Jairo A Diaz,Mauricio F Murillo,Jhonan A Mendoza et al.
Jairo A Diaz et al.
Emergent biological responses develop via unknown processes dependent on physical collision. In hypoxia, when the tissue architecture collapses but the geometric core is stable, actin cytoskeleton filament components emerge, revealing a hid...
CRISPR/Cas9 and mitochondrial gene replacement therapy: promising techniques and ethical considerations [0.03%]
CRISPR/Cas9和线粒体基因置换治疗：前景与伦理挑战
Sarah Fogleman,Casey Santana,Casey Bishop et al.
Sarah Fogleman et al.
Thousands of mothers are at risk of transmitting mitochondrial diseases to their offspring each year, with the most severe form of these diseases being fatal [1]. With no cure, transmission prevention is the only current hope for decreasing...
Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim [0.03%]
非格司亭药物预处理能够短期体外扩增人脐血造血干细胞
Nikolaos G Grigoriadis,Ioannis G Grigoriadis,Sofia Markoula et al.
Nikolaos G Grigoriadis et al.
Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinde...
Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule [0.03%]
神经上皮干细胞诱导感觉神经元的分化及其调控机制研究(ISX9小分子的筛选与鉴定)
Rouknuddin Qasim Ali,Evelina Blomberg,Anna Falk et al.
Rouknuddin Qasim Ali et al.
Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage res...
Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype [0.03%]
父亲孕前暴露对其子代的影响：从表观遗传学到表型
Jonathan Day,Soham Savani,Benjamin D Krempley et al.
Jonathan Day et al.
Historically, research into congenital defects has focused on maternal impacts on the fetal genome during gestation and prenatal periods. However, recent findings have sparked interest in epigenetic alterations of paternal genomes and its e...
Carol J Barnes,Casey T Distaso,Kristin M Spitz et al.
Carol J Barnes et al.
Acute kidney injury (AKI) is the rapid onset of decreased kidney function that ultimately increases mortality and morbidity. Stem cell research is a promising avenue for curative and preventative therapies of kidney injury, however, there a...
The effect of autologous bone marrow mononuclear cell transplantation on the survival duration in Amyotrophic Lateral Sclerosis - a retrospective controlled study [0.03%]
自体骨髓单个核细胞移植对延髓 lateral 肌萎缩症生存期的影响——一项回顾性研究
Alok K Sharma,Hemangi M Sane,Amruta A Paranjape et al.
Alok K Sharma et al.
Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disorder with fatal prognosis. Cellular therapy has been studied for ALS in various animal models and these advances have highlighted its potential to be a treat...
An effective freezing/thawing method for human pluripotent stem cells cultured in chemically-defined and feeder-free conditions [0.03%]
在化学定义和无饲养层条件下培养的人多能干细胞的有效冻存/解冻方法
Naoki Nishishita,Marie Muramatsu,Shin Kawamata
Naoki Nishishita
Culturing human Pluripotent Stem Cells (hPSC)s in chemically defined medium and feeder-free condition can facilitate metabolome and proteome analysis of culturing cells and medium, and reduce regulatory concerns for clinical application of ...
Experimental approaches to derive CD34+ progenitors from human and nonhuman primate embryonic stem cells [0.03%]
从人类和非人灵长类胚胎干细胞中获取CD34+前体细胞的实验性方法
Qiang Shi,John L VandeBerg
Qiang Shi
Traditionally, CD34 positive cells are predominantly found in the umbilical cord and bone marrow, thus are considered as hematopoietic progenitors. Increasing evidence has suggested that the CD34+ cells represent a distinct subset of cells ...
Stem cells for the cell and molecular therapy of type 1 diabetes mellitus (T1D): the gap between dream and reality [0.03%]
用于1型糖尿病细胞和分子治疗的干细胞：梦想与现实之间的差距
Riccardo Calafiore,Giuseppe Basta
Riccardo Calafiore
In spite of intense research, over the past 2-3 decades, targeted to validating methods for the cure of T1D, based on cell substitution therapy in the place of exogenously administered insulin injections, achievement of the final goal conti...