A bioactive composite of freeze-dried stem cells, porous microcarriers, and fibrinogen-thrombin gel for dental pulp tissue engineering [0.03%]
基于冻干干细胞、多孔微载体和纤维蛋白原-凝血酶凝胶的用于牙髓组织工程的生物活性复合物
Mariam Z Kakabadze,Tamta Jikia,Teona Paresishvili et al.
Mariam Z Kakabadze et al.
Background: The aim of this study was to develop a novel biocompatible composite for the regeneration of damaged dental pulp tissue. Materials and methods...
GDF11 activates AMPK-dependent mitophagy to drive osteogenic differentiation of rat bone marrow mesenchymal stem cells [0.03%]
GDF11通过激活AMPK依赖的线粒体自噬促进大鼠骨髓间充质干细胞成骨分化
Xinfeng Gao,Qiting He,Junjun Chen et al.
Xinfeng Gao et al.
Background: Growth differentiation factor 11 (GDF11) has emerged as a potential regulator of bone regeneration; however, the molecular mechanisms through which it influences osteogenic differentiation, particularly in rel...
First live births after adipose-derived stem cells and platelet-rich plasma intraovarian administration [0.03%]
自体脂肪干细胞和富血小板血浆卵巢内注射治疗女性难治性不孕临床研究——首例活产报告
Zaher Merhi,Bhavika Garg,Jessica Haroun
Zaher Merhi
This report describes two women aged 45 and older who achieved live births following intraovarian administration of a novel combination of mechanically processed adipose nanofat rich in adipose-derived stem cells (ADSCs) and autologous plat...
Exosome-rich mesenchymal stem cell secretome improves strength in patients with amyotrophic lateral sclerosis, Kennedy disease, congenital myasthenic syndrome and Lewy body dementia [0.03%]
富含外泌体的间充质干细胞分泌组可改善肌萎缩侧索硬化症、肯尼迪病、先天性肌无力综合征和路易体痴呆患者的肌肉力量
Chadwick C Prodromos,Ruby Del Villar,Max Y Jin et al.
Chadwick C Prodromos et al.
Aim: Amyotrophic lateral sclerosis (ALS), Lewy Body dementia (LBD), Kennedy disease (KD), and Congenital Myasthenic Syndrome (CMS) are progressive motor disorders for which no disease modifying treatment exists. ALS and L...
The role of FN1 gene interference in neural differentiation of human bone marrow mesenchymal stem cells [0.03%]
FN1基因干扰对人骨髓间充质干细胞神经分化的作用
Buhe Buren,Chaoqian Han,Chenyuan Yang et al.
Buhe Buren et al.
Objective: Fibronectin 1 (FN1) encodes fibronectin, a protein essential for cell adhesion, migration, extracellular matrix assembly, and regulation of cell differentiation and proliferation. While FN1 has been implicated ...
Innovative approaches in neural stem cell therapy: a comprehensive review of mechanisms and applications [0.03%]
神经干细胞治疗的创新方法：机制和应用的全面回顾
Nicholas Panin,Luis Torres,Yug Patel et al.
Nicholas Panin et al.
Stem cell therapy is revolutionizing the treatment of neurological disorders, offering innovative approaches for regeneration and repair. This paper explores five distinct mechanisms of stem cell therapy, focusing on their applications and ...
Comparison of differentiation potential of ovarian surface epithelial stem cells into Oocyte-like cells between human- and mice-derived cells [0.03%]
人源和鼠源卵巢干细胞体外诱导形成卵母细胞样细胞的比较研究
Amoura M Abou-El-Naga,Mohamed A M Sobh,Mohamed M Fathy et al.
Amoura M Abou-El-Naga et al.
Background: The ovarian surface epithelium (OSE) stem cells are crucial components of the human ovary and play a significant role in both the reproductive function and ovulatory wound repair. Harnessing these stem cells c...
Synergistic growth factors preconditioning strategy to improve hepatic differentiation efficiency of UC-MSCs in vitro [0.03%]
联合生长因子预处理提高UC-MSCs体外向肝细胞诱导分化效率的研究
Zahid Habib Qureshi,Tahir Maqbool,Bakhtawar Farooq et al.
Zahid Habib Qureshi et al.
Background: Liver diseases remain a major global health burden, with limited treatment options for advanced hepatic dysfunction. Stem cell-based therapies offer a favorable strategy for liver regeneration by providing a r...
Analysis of key immune genes in mesenchymal stem cells in a 3D environment [0.03%]
三维环境中间充质干细胞关键免疫基因的分析
Haojiang Li,Jianfei Gao,Ren Zhang et al.
Haojiang Li et al.
Objective: The aim of this study was to identify the different immune-related genes (DIRGs) of mesenchymal stem cells (MSCs) in three-dimensional (3D) vs. two-dimensional (3D) environment. ...
Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell transplantation in type 2 diabetes: a pilot clinical trial [0.03%]
同种异体脐带来源间充质干细胞移植治疗2型糖尿病的临床研究：一项前瞻性试验
Ramin Raoufinia,Jalil Tavakol-Afshari,Mozhgan Afkhamizadeh et al.
Ramin Raoufinia et al.
Background: Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and β-cell dysfunction, with chronic inflammation playing a central pathogenic role. Mesenchymal stem cells (MSCs) possess therapeutic po...