Highs and Lows: A Mixed-Methods Analysis of the Impact of Adult Use Legalization on Medical Cannabis Patients [0.03%]
起起落落：成人使用大麻合法化对医疗大麻患者影响的混合方法分析
Kevin F Boehnke,Daniel J Kruger,Carrie Cuttler et al.
Kevin F Boehnke et al.
Presently, 24 states have legalized adult use (recreational) cannabis, each following medical-only access. Although states that pass adult use laws report substantial declines in the number of registered medical patients, these laws expand ...
24-Hour Induction of Transdermal Buprenorphine to Buprenorphine Extended-Release [0.03%]
透皮丁丙诺啡至丁丙诺啡缓释剂24小时诱导转换疗法
Pouya Azar,Victor W Li,James S H Wong et al.
Pouya Azar et al.
Buprenorphine is an effective treatment for opioid use disorder but can be slow when using a standard low-dose titration protocol to avoid precipitated withdrawal. This presents a substantial practical barrier in clinical practice. Recent l...
The Effect of Psilocybe cubensis on Spatial Memory and BDNF Expression in Male Rats Exposed to Chronic Unpredictable Mild Stress [0.03%]
Psilocybe cubensis对慢性轻度不可预测应激雄性大鼠空间记忆及脑源性神经营养因子表达的影响
Reza Ghaffarzadegan,Mokhtar Karimi,Behnaz Hedayatjoo et al.
Reza Ghaffarzadegan et al.
Psilocybin-containing mushrooms, commonly known as magic mushrooms, drastically affect mental processing, cognitive functioning, and the mood state. In the present study, we investigated the effect of the Psilocybe cubensis extract on spati...
Efficacy of Screening and Brief Intervention for Alcohol Misuse in Opioid Agonist Maintenance Treatment: A Randomized Clinical Trial [0.03%]
阿片受体激动剂维持治疗中筛查和简短干预治疗酒精使用障碍的疗效研究：一项随机临床试验
Surabhi Gupta,Renjith R Pillai,Abhishek Ghosh
Surabhi Gupta
Alcohol misuse is common in persons on opioid agonist maintenance treatment (OAMT). We tested the efficacy of screening and brief intervention (SBI) for harmful/hazardous alcohol use in buprenorphine/naloxone (BNX)-assisted OAMT. It was a d...
The Risk Assessment Before Dose Tapering Among Methadone Maintenance Treatment Participants: Derivation and Validation of a Nomogram [0.03%]
美沙酮维持治疗患者减量前风险评估积分量表的构建及验证
Chijie Wang,Qian Lu,Boyu Li et al.
Chijie Wang et al.
Many methadone maintenance treatment (MMT) participants experienced a tapering phase. The benefit of tapering is based on a balance between meeting the desire to reduce methadone dose and reduction in relapse. We aimed to develop and valida...
Jake Scarcella,Jeffrey MacDaniels,Lucinda Coffin et al.
Jake Scarcella et al.
Esketamine, the isolated S-enantiomer of ketamine, has been a recent breakthrough as a non-monoaminergic treatment for treatment-resistant depression (TRD). This case report explores a rare adverse event in a 41-year-old female with TRD, wh...
Sean M Viña
Sean M Viña
Psychedelic use has been increasingly accepted socially and legally. However, there is a gap in understanding how religion can influence the relationship between psychedelics and mental health. This study aims to explore this relationship b...
Aggression in a Cohort of Male Methamphetamine (METH) Users With and Without Kratom (Mitragyna speciosa Korth.) Use History in Malaysia [0.03%]
马来西亚甲氨蝶呤(METH)男使用者群体中 kratom( Mitragyna speciosa Korth.)使用史有无差异的攻击性研究
Yuting Yang,Christian P Müller,Darshan Singh
Yuting Yang
Methamphetamine (METH) consumption is associated with aggression. Decoction derived from the kratom (Mitragyna speciosa Korth.) leaf has been used as a METH substitute in Southeast Asia. Given its perceived benefit, we investigated the rela...
Global Trends in Psychedelic Microdosing: Demographics, Substance Testing Behavior, and Patterns of Use [0.03%]
全球迷幻剂微量服用趋势：人口统计、药品检测行为和使用模式
Omer A Syed,Rotem Petranker,Emily C Fewster et al.
Omer A Syed et al.
Despite psychedelic microdosing being a growing practice, the research on the topic is still in its infancy. While several studies have described the characteristics, motivations and practices of microdosers, the differences between individ...
Masking Influences: A Systematic Review of Placebo Control and Masking in Psychedelic Studies [0.03%]
制约因素：安慰剂控制和双盲在迷幻药物研究中的系统性综述
Aleksandra Barstowe,Petri J Kajonius
Aleksandra Barstowe
Psychedelic-assisted therapy is becoming increasingly acknowledged as an effective therapeutic intervention for various psychiatric illnesses. However, the evaluation of masking success is rarely reported in trials. The objective of the pre...