Addition of the immunostimulatory oligonucleotide IMT504 to a seasonal flu vaccine increases hemagglutinin antibody titers in young adult and elder rats, and expands the anti-hemagglutinin antibody repertoire [0.03%]
免疫刺激寡核苷酸IMT504增效季节性流感疫苗，增加年轻成人和老年大鼠血凝素抗体滴度并扩大抗血凝素抗体谱系
Alejandro Daniel Montaner,Analía Denichilo,Juan Manuel Rodríguez et al.
Alejandro Daniel Montaner et al.
Flu vaccines are partially protective in infants and elder people. New adjuvants such as immunostimulatory oligonucleotides (ODNs) are strong candidates to solve this problem, because a combination with several antigens has demonstrated eff...
Selection of the most potent specific on/off adaptor-hepatitis delta virus ribozymes for use in gene targeting [0.03%]
用于基因定位的最有效的特异开关型乙型肝炎病毒核酶的选择
Michel V Lévesque,Samuel G Rouleau,Jean-Pierre Perreault
Michel V Lévesque
The Hepatitis Delta Virus (HDV) ribozyme, which is well adapted to the environment of the human cell, is an excellent candidate for the future development of gene-inactivation systems. On top of this, a new generation of HDV ribozymes now e...
Adjuvant properties of Cytosine-phosphate-guanosine oligodeoxynucleotide in combination with various polycations in an ovalbumin-vaccine model [0.03%]
卵清蛋白疫苗模型中CpG寡聚脱氧核苷酸与各种多阳离子类物质联合应用的佐剂性能研究
Sylvie Maubant,Claire Banissi,Samantha Beck et al.
Sylvie Maubant et al.
Oligonucleotides containing CpG motifs (cytosine-phosphate-guanosine oligodeoxynucleotide [CpG ODN]) display strong immunostimulatory effects, and polycations have been previously reported as cellular delivery system. In the present study, ...
Comparative Study
Nucleic acid therapeutics. 2011 Aug;21(4):231-40. DOI:10.1089/nat.2011.0291 2011
Adjuvant properties of Cytosine-phosphate-guanosine oligodeoxynucleotide in combination with various polycations in an ovalbumin-vaccine model [0.03%]
卵清蛋白疫苗模型中各种多阳离子与胞苷磷酸鸟苷寡脱氧核苷酸联合使用的佐剂性质
Sylvie Maubant,Claire Banissi,Samantha Beck et al.
Sylvie Maubant et al.
Oligonucleotides containing CpG motifs (cytosine-phosphate-guanosine oligodeoxynucleotide [CpG ODN]) display strong immunostimulatory effects, and polycations have been previously reported as cellular delivery system. In the present study, ...
Comparative Study
Nucleic acid therapeutics. 2011 Aug;21(4):231-40. DOI:10.1089/nat.2011.0291 2011
Dissection of the functional structure of aptamer17, which specifically recognizes differentiated PC12 cells [0.03%]
拆分特异性识别分化PC12细胞的适配子aptamer17的功能结构
Jiao-Jiao Liu,Cheng-Long Wang,Qing Xi et al.
Jiao-Jiao Liu et al.
A specific single-stranded DNA (ssDNA) aptamer (aptamer17) that specifically recognizes differentiated PC12 cells had been previously obtained after 6 rounds of whole cell-based subtractive systematic evolution of ligands by exponential enr...
Dissection of the functional structure of aptamer17, which specifically recognizes differentiated PC12 cells [0.03%]
拆分特异性识别分化PC12细胞的适配子aptamer17的功能结构
Jiao-Jiao Liu,Cheng-Long Wang,Qing Xi et al.
Jiao-Jiao Liu et al.
A specific single-stranded DNA (ssDNA) aptamer (aptamer17) that specifically recognizes differentiated PC12 cells had been previously obtained after 6 rounds of whole cell-based subtractive systematic evolution of ligands by exponential enr...
Immune activation and target organ damage are consequences of hydrodynamic treatment but not delivery of naked siRNAs in mice [0.03%]
免疫激活和靶器官损伤是液体静力学处理而不是裸siRNA在小鼠中的传递后果
Zsuzsanna Rácz,Mária Godó,Csaba Révész et al.
Zsuzsanna Rácz et al.
Short-interfering RNAs (siRNAs), key mediators of RNA interference comprise a promising therapeutic tool, although side effects such as interferon (IFN) response are still not perfectly understood. Further, delivery to target organs is a ma...
Immunostimulatory potential of silencing RNAs can be mediated by a non-uridine-rich toll-like receptor 7 motif [0.03%]
沉默RNA的免疫刺激潜能可通过非尿嘧啶丰富的TLR7基序介导
Marion Jurk,Ghania Chikh,Bettina Schulte et al.
Marion Jurk et al.
Microbial infections trigger a multiplicity of responses in the host via innate immune sensors, including the Toll-like receptors (TLRs). TLR7 and TLR8, located in endosomes, detect pathogen-derived RNA, which can be mimicked by synthetic s...
Immunostimulatory potential of silencing RNAs can be mediated by a non-uridine-rich toll-like receptor 7 motif [0.03%]
沉默RNA的免疫刺激潜能可通过非尿嘧啶富集的TLR7基序介导
Marion Jurk,Ghania Chikh,Bettina Schulte et al.
Marion Jurk et al.
Microbial infections trigger a multiplicity of responses in the host via innate immune sensors, including the Toll-like receptors (TLRs). TLR7 and TLR8, located in endosomes, detect pathogen-derived RNA, which can be mimicked by synthetic s...
Xiaohui Ji,Hongxia Sun,Huaxi Zhou et al.
Xiaohui Ji et al.
RNA/DNA sequences rich in guanine (G) can form a 4-strand structure, G-quadruplex, which has been extensively researched and observed in mammalian, fungi, and plants, with in vivo existence in eukaryotic cells. Compared with DNA quadruplex,...