Subclinical rejection in renal transplants is associated with low serum mannose-binding lectin levels [0.03%]
肾移植亚临床排斥反应与低血清甘露聚糖结合凝集素水平有关
Meritxell Ibernon,Francesc Moreso,Daniel Serón
Meritxell Ibernon
Surveillance biopsies have contributed to the understanding of the natural history of renal allograft lesions. Subclinical rejection, defined as the presence of histological lesions, indistinguishable from acute rejection in stable grafts, ...
Changes in the number of circulating TCM and TEM subsets in renal transplantation: relationship with acute rejection and induction therapy [0.03%]
肾脏移植后外周循环中TCM和TEM亚群的变化及其与急性排斥反应和诱导治疗的关系
David S Segundo,Gema Fernández-Fresnedo,María Gago et al.
David S Segundo et al.
Effector (TEM) and central memory (TCM) T cells have been recently described as the main memory T-cell subsets generated after primary immune response, with a potential role in graft rejection after rechallenge with alloantigen. Because of ...
T-cell co-stimulatory blockade in kidney transplantation: back to the bench [0.03%]
肾脏移植中的T细胞共刺激阻断：重返试验台
Leonardo V Riella,Mohamed H Sayegh
Leonardo V Riella
It is believed that blocking positive T-cell co-stimulatory pathways should lead to long-term graft acceptance. Despite the exciting initial achievements in experimental animal models, targeting co-stimulatory pathways has shown to be much ...
The lingering dilemma of arterial pressure in CKD: what do we know, where do we go? [0.03%]
CKD患者动脉僵硬度与血压的关系：现状和未来研究方向展望
Rajiv Agarwal,Alberto Martinez-Castelao,Andrzej Wiecek et al.
Rajiv Agarwal et al.
Despite many advances in the management of hypertensive chronic kidney disease (CKD) patients, both on and off dialysis, there exist several gaps in our knowledge. Although the modern techniques to measure blood pressure (BP) indirectly hav...
Major pathways of the reno-cardiovascular link: the sympathetic and renin-angiotensin systems [0.03%]
肾脏-心血管系统联系的主要途径：交感神经系统和肾素-血管紧张素系统
Peter J Blankestijn,Gerard London,Danilo Fliser et al.
Peter J Blankestijn et al.
Chronic kidney disease is often characterized by enhanced activity of the renin-angiotensin system (RAS) and the sympathetic nervous system. Independent of their effect on blood pressure, these systems also contribute to the pathogenesis of...
Arterial aging and arterial disease: interplay between central hemodynamics, cardiac work, and organ flow-implications for CKD and cardiovascular disease [0.03%]
动脉老化与动脉疾病：中心循环动力学、心脏功能和器官灌注之间的相互作用及其对慢性肾病和心血管疾病的意义
Gerard London,Adrian Covic,David Goldsmith et al.
Gerard London et al.
Cardiovascular disease is an important cause of morbidity and mortality in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). All epidemiological studies have clearly shown that accelerated arterial and cardiac a...
The dysfunctional endothelium in CKD and in cardiovascular disease: mapping the origin(s) of cardiovascular problems in CKD and of kidney disease in cardiovascular conditions for a research agenda [0.03%]
CKD和心血管疾病中的功能不全内皮细胞：绘制CKD患者心血管问题以及心血管疾病的肾病发病机制的研究路线图
Danilo Fliser,Andrzej Wiecek,Gultekin Suleymanlar et al.
Danilo Fliser et al.
Endothelial dysfunction resulting in disintegration of vascular structure and function is a key element in the progression of chronic kidney disease (CKD). Many risk factors-traditional and non-traditional-are thought to have a role in the ...