Mineral and bone disorders in chronic kidney disease and end-stage renal disease patients: new insights into vitamin D receptor activation [0.03%]
慢性肾脏病和终末期肾病患者的矿物质和骨骼异常：维生素D受体激活的新见解
Jordi Bover,Mario Cozzolino
Jordi Bover
Progressive loss of kidney function leads to reduced production of calcitriol (1,25-dihydroxyvitamin D; active vitamin D) and an imbalance in serum calcium (Ca) and phosphorus (P) levels, which are associated with progression of renal failu...
Protective actions of administered mesenchymal stem cells in acute kidney injury: relevance to clinical trials [0.03%]
间充质干细胞在急性肾损伤时的保护作用及临床试验的相关性研究
Christof Westenfelder,Florian E Togel
Christof Westenfelder
Current therapies for acute kidney injury remain primarily supportive and have failed to reduce morbidity, mortality (>50%), and associated costs. This prompted our studies in which rats with bilateral ischemia/reperfusion-induced acute kid...
Christina M Takiya,Radovan Borojevic
Christina M Takiya
Patients with terminal cardiac or renal disease have few therapeutic options besides organ transplantation. Optimally, cell therapies would be used both in acute and chronic stages of such diseases. In the injured myocardium, the main thera...
Júlio C Voltarelli,Carlos E B Couri,Maria C Oliveira et al.
Júlio C Voltarelli et al.
In this review, we present (1) a brief discussion of hematopoietic stem cell transplantation (HSCT) for severe and refractory autoimmune diseases (AIDs) from its beginning in 1996 through recently initiated prospective randomized clinical t...
Role of SDF-1 as a regulatory chemokine in renal regeneration after acute kidney injury [0.03%]
SDF-1作为肾急性损伤后修复阶段的调控趋化因子的作用研究
Florian E Togel,Christof Westenfelder
Florian E Togel
Both the homing of hematopoietic stem cells (HSCs) to the bone marrow and their engraftment in recipients of bone marrow transplants are primarily mediated by the chemokine stromal-derived factor-1 (SDF-1) or CXCL12, which activates CXCR4, ...
Genetic tracing of the epithelial lineage during mammalian kidney repair [0.03%]
哺乳动物肾脏修复过程中上皮谱系的基因追踪研究
Benjamin D Humphreys
Benjamin D Humphreys
Developing new therapeutic approaches to treat acute kidney injury requires a detailed understanding of endogenous cellular repair. Genetic fate mapping defines cellular hierarchies in vivo and we used this technique to assess a possible co...
Mesenchymal stromal cells: main factor or helper in regenerative medicine? [0.03%]
间充质基质细胞：再生医学的主要因素还是辅助因素？
Axel R Zander,Claudia Lange,Christof Westenfelder
Axel R Zander
Mesenchymal stromal cells (mSCs) are presently studied for the prophylaxis and therapy of a variety of diseases such as acute graft-versus-host disease after allogeneic stem cell transplantation, cardiac indications, bone degeneration, Croh...
Mesenchymal stem cells as a therapeutic approach to glomerular diseases: benefits and risks [0.03%]
间充质干细胞在肾小球疾病治疗中的作用：利与弊
Uta Kunter,Song Rong,Marcus J Moeller et al.
Uta Kunter et al.
Most studies using adult stem cells (ASCs) and progenitor cells as potential therapeutics for kidney disorders have been conducted in models of acute kidney injury, where the damage mainly affects the tubulointerstitium. The results are pro...
NKG2D and its ligands: active factors in the outcome of solid organ transplantation? [0.03%]
NKG2D及其配体：实体器官移植结果的促炎症因素？
Beatriz Suárez-Álvarez,Alba Fernández-Sánchez,Antonio López-Vázquez et al.
Beatriz Suárez-Álvarez et al.
The role of natural killer (NK) cells in solid organ transplantation is not well established, although several recent reports highlight the importance of the activating receptor NKG2D and its ligands in the development of rejection during t...
Esperanza Perucha,Irene Rebollo-Mesa,Pervinder Sagoo et al.
Esperanza Perucha et al.
Induction of transplantation tolerance remains the ideal long-term clinical and logistic solution to the current challenges facing the management of renal allograft recipients. In this review, we describe the recent studies and advances mad...