High-Throughput Experimentation and Continuous Flow Evaluation of Nucleophilic Aromatic Substitution Reactions [0.03%]
亲核芳香取代反应的高通量实验及连续流评价
Zinia Jaman,David L Logsdon,Botond Szilágyi et al.
Zinia Jaman et al.
Nucleophilic aromatic substitution (SNAr) reactions were optimized using high-throughput experimentation techniques for execution under flow conditions. A total of 3072 unique reactions were evaluated with an analysis time of ∼3.5 s per re...
Static Combinatorial Chemistry: A High-Pressure Approach to the Synthesis of Macrocyclic Benzoamide Libraries [0.03%]
高压合成大环苯甲酰胺化合物组合化学库的一种静态方法研究
Grzegorz Pikus,Agata Tyszka-Gumkowska,Janusz Jurczak
Grzegorz Pikus
We investigated the yield and distribution of macrocyclic products formed in combinatorial libraries (CLs) obtained via double-amidation reactions of methyl diesters with α,ω-diamines. The application of the static combinatorial chemistry...
High-Throughput Synthesis and Screening of Rapidly Degrading Polyanhydride Nanoparticles [0.03%]
高效合成和筛选快速降解的聚酐纳米颗粒
Adam S Mullis,Sarah J Jacobson,Balaji Narasimhan
Adam S Mullis
Combinatorial techniques can accelerate the discovery and development of polymeric nanodelivery devices by pairing high-throughput synthesis with rapid materials characterization. Biodegradable polyanhydrides demonstrate tunable release, hi...
Combined Spatially Resolved Characterization of Antireflection and Antisoiling Coatings for PV Module Glass [0.03%]
光伏组件玻璃的抗反射和防污涂层的综合空间分辨特性研究
Stephanie L Moffitt,Conor Riley,Benjamin H Ellis et al.
Stephanie L Moffitt et al.
Characterization of photovoltaic (PV) module materials throughout different stages of service life is crucial to understanding and improving the durability of these materials. Currently the large-scale of PV modules (>1 m2) is imbalanced wi...
Critical Evaluation of Photo-cross-linking Parameters for the Implementation of Efficient DNA-Encoded Chemical Library Selections [0.03%]
DNA编码化合物文库筛选中光交联条件的优化及关键参数评估研究
Alessandro Sannino,Adrián Gironda-Martínez,Émile M D Gorre et al.
Alessandro Sannino et al.
The growing importance of DNA-encoded chemical libraries (DECLs) as tools for the discovery of protein binders has sparked an interest for the development of efficient screening methodologies, capable of discriminating between high- and med...
Thin-Film Microtensile-Test Structures for High-Throughput Characterization of Mechanical Properties [0.03%]
薄膜微拉伸测试结构用于机械性能的高通量表征
T Oellers,V G Arigela,C Kirchlechner et al.
T Oellers et al.
A photolithographic process for the rapid fabrication of thin-film tensile-test structures is presented. The process is applicable to various physical vapor deposition techniques and can be used for the combinatorial fabrication of thin-fil...
Diversity-Oriented Library Synthesis from Steviol and Isosteviol-Derived Scaffolds [0.03%]
从 steviol 和 isosteviol 衍生物支架出发的多样性导向的库合成
Trinh A D Holth,Michael A Walters,Oliver E Hutt et al.
Trinh A D Holth et al.
The readily available natural product stevioside provides a unique diterpene core structure that can be explored for small molecule library development by diversity-oriented synthesis and functional group transformations. Validation arrays ...
Design of an Automated Reagent-Dispensing System for Reaction Screening and Validation with DNA-Tagged Substrates [0.03%]
基于DNA标记底物的反应筛选与验证的自动化试剂分配系统的设计
Jens Bobers,Mateja Klika Škopić,Robin Dinter et al.
Jens Bobers et al.
Laboratory automation strategies have vast potential for accelerating discovery processes. They enable higher efficiency and throughput for time-consuming screening procedures and reduce error-prone manual steps. Automating repetitive proce...
Palladium-Catalyzed Cascade Reactions of δ-Ketonitriles with Arylboronic Acids: Synthesis of Pyridines [0.03%]
钯催化δ-酮腈与arylboronic酸的级联反应制吡啶类化合物
Xinrong Yao,Linjun Qi,Renhao Li et al.
Xinrong Yao et al.
This study presents the first example of the Pd-catalyzed cascade reactions of 5-oxohexanenitrile with arylboronic acids, affording important synthon 2-methylpyridines that can be further translated through C(sp3)-H functionalization to con...
An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations under Anhydrous Conditions for DNA-Encoded Library Synthesis [0.03%]
两亲性聚合物支持的策略实现无水条件下的化学转化用于DNA编码库合成
Yves Ruff,Roberto Martinez,Xavier Pellé et al.
Yves Ruff et al.
The use of DNA-encoded libraries has emerged as a powerful hit generation technology. Combining the power of combinatorial chemistry to enumerate large compound collections with the efficiency of affinity selection in pools, the methodology...