Dielectrophoretic Manipulation of Cancer Cells and Their Electrical Characterization [0.03%]
癌症细胞的介电泳操作及其电气特性分析
Ina Turcan,Marius Andrei Olariu
Ina Turcan
Electromanipulation and electrical characterization of cancerous cells is becoming a topic of high interest as the results reported to date demonstrate a good differentiation among various types of cells from an electrical viewpoint. Dielec...
Considerations for Achieving Maximized DNA Recovery in Solid-Phase DNA-Encoded Library Synthesis [0.03%]
实现固相DNA编码库合成中DNA回收最大化的考虑因素
Alexander K Price,Brian M Paegel
Alexander K Price
DNA-encoded library (DEL) technology enables rapid, economical synthesis, and exploration of novel chemical space. Reaction development for DEL synthesis has recently accelerated in pace with a specific emphasis on ensuring that the reactio...
Synthesis of Bioactive Complex Small Molecule-Ciprofloxacin Conjugates and Evaluation of Their Antibacterial Activity [0.03%]
具有生物活性的复合小分子-环丙沙星连接物的合成及其抗菌活性评价
Rahul Upadhyay,Rahul Kumar,Manoj Jangra et al.
Rahul Upadhyay et al.
Conjugates between pharmaceuticals and small molecules enable access to a vast chemical space required for the discovery of new lead molecules with modified therapeutic potential. However, the dearth of specific chemical reactions that are ...
Valence Band Modification of a (GaxIn1- x)2O3 Solid Solution System Fabricated by Combinatorial Synthesis [0.03%]
基于组合合成的(GaxIn1-x)2O3固溶体系价带调控研究
Takahiro Nagata,Takeshi Hoga,Akihiro Yamashita et al.
Takahiro Nagata et al.
The correlation between the crystal structure and valence band structure of a (GaxIn1-x)2O3 solid solution system was investigated by using combinatorial synthesis. At a low Ga content of (GaxIn1-x)2O3 with a single-phase cubic In2O3 crysta...
Facile Synthesis of Novel Hexahydroimidazo[1,2- a]pyridine Derivatives by One-Pot, Multicomponent Reaction under Ambient Conditions [0.03%]
环境条件下一步多组分反应合成新型六氢咪唑并吡啶衍生物
Hongbo Tan,Yinfeng Wang
Hongbo Tan
An efficient one-pot multicomponent reaction for the synthesis of novel tetrasubstituted hexahydroimidazo[1,2-a]pyridines starting from readily available cinnamaldehydes, ethylenediamines, and 1,3-dicarbonyl compounds catalyzed by AcOH is d...
One Reacts as Two: Applications of N-Isocyaniminotriphenylphosphorane in Diversity-Oriented Synthesis [0.03%]
一反应变两反应：N-异氰亚胺三苯基磷在导向多样性合成中的应用
Gerardo M Ojeda-Carralero,Leonardo G Ceballos,Julieta Coro et al.
Gerardo M Ojeda-Carralero et al.
N-Isocyaniminotriphenylphosphorane (NIITP) is a functionalized isonitrile that has been extensively applied in a variety of organic reactions during the last two decades. This Review summarizes the most important applications in organic syn...
Efficient Arylation of 2,7-Naphthyridin-1(2 H)-one with Diaryliodonium Salts and Discovery of a New Selective MET/AXL Kinase Inhibitor [0.03%]
二芳基碘化盐催化2,7-恶萘啶酮的高效 arylation 反应及一种新型MET/AXL 蛋白激酶选择性抑制剂的研究
Ming-Shu Wang,Hong-Chuang Xu,Yi Gong et al.
Ming-Shu Wang et al.
New 8-chloro-2-phenyl-2,7-naphthyridin-1(2H)-one building blocks bearing diverse substitutes on the 2-phenyl group were synthesized via an efficient diaryliodonium salt-based N-arylation strategy with the advantage of mild conditions, short...
Mohammad Taghi Nazeri,Hassan Farhid,Reza Mohammadian et al.
Mohammad Taghi Nazeri et al.
Ugi four-component reactions (U-4CRs) are widely recognized as being highly efficient for the synthesis of pseudopeptides. However, the products of these reactions are not so interesting as drug candidates because they are not conformationa...
Combinatorial Resurfacing of Dengue Envelope Protein Domain III Antigens Selectively Ablates Epitopes Associated with Serotype-Specific or Infection-Enhancing Antibody Responses [0.03%]
选择性消除登革病毒血清型特异性或感染增强抗体反应表位的嵌合结构域III抗原组合改造技术
Jennifer L Remmel,Kathryn S Beauchemin,Akaash K Mishra et al.
Jennifer L Remmel et al.
Mutagenesis of surface-exposed residues, or "resurfacing", is a protein engineering strategy that can be utilized to disrupt antibody recognition or modulate the capacity of a protein to elicit antibody responses. We apply resurfacing to en...
Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization [0.03%]
实验材料科学中的研究数据管理快速入门-为研究小组级别的材料数字化奠定基础
Lars Banko,Alfred Ludwig
Lars Banko
Research data management is a major necessity for the digital transformation in material science. Material science is multifaceted and experimental data, especially, is highly diverse. We demonstrate an adjustable approach to a group level ...