Development of an Aptamer-Based Lateral Flow Assay for the Detection of C-Reactive Protein Using Microarray Technology as a Prescreening Platform [0.03%]
利用芯片技术作为预筛查平台开发一种基于侧向流动试纸的适体法检测C反应蛋白的方法
Ngoc Linh Phung,Johanna G Walter,Rebecca Jonczyk et al.
Ngoc Linh Phung et al.
For improved cost-effectiveness and temperature-stability, a ready to use lateral flow assay (LFA) is developed in this work for detecting inflammation/infection biomarker C-reactive protein (CRP) in human patient samples on the basis of ap...
Rapid Synthesis of a Natural Product-Inspired Uridine Containing Library [0.03%]
灵感来自天然产物的尿苷类化合物库的快速合成
Wei-Chieh Cheng,Wan-Ju Liu,Kung-Hsiang Hu et al.
Wei-Chieh Cheng et al.
The preparation of natural product-inspired nucleoside analogs using solution-phase parallel synthesis is described. The key intermediates containing alkyne and N-protected amino moieties were developed to allow for further skeleton and sub...
Diversity-Oriented Synthesis of Thiazolidine-2-imines via Microwave-Assisted One-Pot, Telescopic Approach and Its Interaction with Biomacromolecules [0.03%]
微波辅助一锅串联合成导向的噻唑烷-2-亚胺类化合物及其与生物大分子的作用研究
Ananya Anubhav Saikia,Ramdas Nishanth Rao,Barnali Maiti et al.
Ananya Anubhav Saikia et al.
In this work, a one-pot, telescopic approach is described for the combinatorial library of thiazolidine-2-imines. The synthetic manipulation proceeds smoothly via the reaction of 2-aminopyridine/pyrazine/pyrimidine with substituted isothioc...
MoS2-Calix[4]arene Catalyzed Synthesis and Molecular Docking Study of 2,4,5-Trisubstituted Imidazoles As Potent Inhibitors of Mycobacterium tuberculosis [0.03%]
作为抗结核分枝杆菌的有效抑制剂的2，4,5-三取代咪唑的MoS2-Calix[4]arene催化合成及分子对接研究
Madihalli S Raghu,Chikkur B Pradeep Kumar,Kodalapura N Nagendra Prasad et al.
Madihalli S Raghu et al.
A MoS2-supported-calix[4]arene (MoS2-CA4) nanocatalyst was used for efficient synthesis of 2,4,5-trisubstituted imidazole derivatives from 1-(4-nitrophenyl)-2-(4-(trifluoromethyl)phenyl)ethane-1,2-dione, aldehydes and ammonium acetate under...
Valerie Cavett,Brian M Paegel
Valerie Cavett
Emulsions offer the means to miniaturize and parallelize high-throughput screening but require a robust method to localize activity-based fluorescent probes in each droplet. Multiplexing probes in droplets is impractical, though highly desi...
Comprehensive Prediction of Molecular Recognition in a Combinatorial Chemical Space Using Machine Learning [0.03%]
使用机器学习在组合化学空间中全面预测分子识别
Alexander T Taguchi,James Boyd,Chris W Diehnelt et al.
Alexander T Taguchi et al.
In combinatorial chemical approaches, optimizing the composition and arrangement of building blocks toward a particular function has been done using a number of methods, including high throughput molecular screening, molecular evolution, an...
Rapid Assembly and Screening of Multivalent Immune Cell-Redirecting Therapies for Leukemia [0.03%]
用于白血病的多价免疫细胞重定向疗法的快速组装和筛选
Priscilla Do,Lacey A Perdue,Andrew Chyong et al.
Priscilla Do et al.
Therapies that bind with immune cells and redirect their cytotoxic activity toward diseased cells represent a promising and versatile approach to immunotherapy with applications in cancer, lupus, and other diseases; traditional methods for ...
Isolation of Chemically Cyclized Peptide Binders Using Yeast Surface Display [0.03%]
使用酵母表面展示技术分离化学环化肽结合物
Kaitlyn Bacon,Abigail Blain,Matthew Burroughs et al.
Kaitlyn Bacon et al.
Cyclic peptides with engineered protein-binding activity have gained increasing attention for use in therapeutic and biotechnology applications. We describe the efficient isolation and characterization of cyclic peptide binders from genetic...
Combinatorial Exploration and Mapping of Phase Transformation in a Ni-Ti-Co Thin Film Library [0.03%]
Ni-Ti-Co薄膜库中相变的组合探索与映射
Naila M Al Hasan,Huilong Hou,Tieren Gao et al.
Naila M Al Hasan et al.
Combinatorial synthesis and high-throughput characterization of a Ni-Ti-Co thin film materials library are reported for exploration of reversible martensitic transformation. The library was prepared by magnetron co-sputtering, annealed in v...
Prospects and Therapeutic Applications of Cardiac Glycosides in Cancer Remediation [0.03%]
心脏糖苷在癌症治疗中的前景和应用
Jude I Ayogu,Amaechi S Odoh
Jude I Ayogu
Active metabolites from natural sources are the predominant molecular targets in numerous biological studies owing to their appropriate compatibility with biological systems and desirable selective toxicities. Thus, their potential for ther...