High Entropy and Sluggish Diffusion "Core" Effects in Senary FCC Al-Co-Cr-Fe-Ni-Mn Alloys [0.03%]
六元FCC Al-Co-Cr-Fe-Ni-Mn合金中的高熵和缓慢扩散“核心”效应
Abhishek Mehta,Yongho Sohn
Abhishek Mehta
Relative role of enthalpy and entropy in the stabilization of senary FCC Al-Co-Cr-Fe-Ni-Mn high entropy alloys was investigated via a high throughput combinatorial solid-to-solid diffusion couple approach. Many off-equiatomic compositions o...
Solution-Phase Fmoc-Based Peptide Synthesis for DNA-Encoded Chemical Libraries: Reaction Conditions, Protecting Group Strategies, and Pitfalls [0.03%]
基于Fmoc的溶液相多肽合成在DNA编码化学库中的应用：反应条件，保护基策略及注意事项
Olivier B C Monty,Nicholas Simmons,Srinivas Chamakuri et al.
Olivier B C Monty et al.
Peptide drug discovery has shown a resurgence since 2000, bringing 28 non-insulin therapeutics to the market compared to 56 since its first peptide drug, insulin, in 1923. While the main method of discovery has been biological display-phage...
An Aptamer Linked Immobilized Sorbent Assay (ALISA) to Detect Circulatory IFN-α, an Inflammatory Protein among Tuberculosis Patients [0.03%]
用于检测结核病患者循环IFN-α（一种炎性蛋白）的适配体连接固定受体测定法（ALISA）
Vibha Taneja,Manish Goel,Uma Shankar et al.
Vibha Taneja et al.
Dysregulation of IFN-α is the basis for pathogenesis of autoimmune as well as infectious diseases. Identifying inflammatory signatures in peripheral blood of patients is an approach for monitoring active infection. Hence, estimation of typ...
Total Synthesis of Semaglutide Based on a Soluble Hydrophobic-Support-Assisted Liquid-Phase Synthetic Method [0.03%]
基于可溶性疏水载体辅助液相合成方法的Semaglutide的全合成研究
Xingbang Liu,Na Zhang,Xiaotong Gu et al.
Xingbang Liu et al.
Considering the high cost of the production of semaglutide, which is currently the most promising antidiabetic drug especially for the treatment of type 2 diabetes mellitus, a new synthetic route of semaglutide production that possesses exc...
Dayu Hu,He Liu,Ye Tian et al.
Dayu Hu et al.
Circulating tumor cells (CTCs) carry reliable clinical information for the diagnosis and treatment of cancer that is a malignant disease with a high mortality rate. However, the amount of CTCs in the blood is quite low. To obtain credible c...
(Hetero-)(arylidene)arylhydrazides as Multitarget-Directed Monoamine Oxidase Inhibitors [0.03%]
(杂)芳亚胺基肼:多靶向单胺氧化酶抑制剂
Ashique Palakkathondi,Jong Min Oh,Sanal Dev et al.
Ashique Palakkathondi et al.
Fourteen (hetero-)(arylidene)arylhydrazide derivatives (ABH1-ABH14) were synthesized, and their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE) were evaluated. Compound ABH5 most potently inhibited MA...
Detection of Thiol Functionality and Disulfide Bond Formation by Polyoxometalate [0.03%]
聚氧簇合物对巯基功函数及二硫键形成的检测
Hiroyuki Konno,Haruto Yasumiishi,Reika Aoki et al.
Hiroyuki Konno et al.
The detection of thiol functionality and intramolecular disulfide bond formation of peptides using the α-Keggin type polyoxometalate molybdenum-oxygen cluster (H3PMo12O40·nH2O) is described. Our method entails the addition of this polyoxo...
Cautionary Guidelines for Machine Learning Studies with Combinatorial Datasets [0.03%]
组合数据集的机器学习研究的注意事项指南
Andrew F Zahrt,Jeremy J Henle,Scott E Denmark
Andrew F Zahrt
Regression modeling is becoming increasingly prevalent in organic chemistry as a tool for reaction outcome prediction and mechanistic interrogation. Frequently, to acquire the requisite amount of data for such studies, researchers employ co...
Multicomponent Petasis Reaction for the Synthesis of Functionalized 2-Aminothiophenes and Thienodiazepines [0.03%]
多功能Petasis反应用于合成官能化2-氨基噻吩和噻吩并 diazepine
Jimin Hwang,Lydia Borgelt,Peng Wu
Jimin Hwang
Multicomponent Petasis reaction has been widely applied for the synthesis of functionalized amine building blocks and biologically active compounds. Employing primary aromatic amines that are not typical reactive substrates contributes to e...
TRAF2 and NCK-Interacting Kinase Inhibitors for Colorectal Cancer: In Vitro and Theoretical Validations [0.03%]
TRAF2和NCK相互作用激酶抑制剂对结肠直肠癌的治疗作用：体外及理论验证
Sherlin Rosita Arokiaraj,Nargis Begum Tajuddin,Karthikeyan Muthusamy et al.
Sherlin Rosita Arokiaraj et al.
TRAF2 and NCK-interacting kinase (TNIK) is a critical factor in colorectal cancer (CRC) proliferation mediated by Wnt signaling. We attempted to identify efficient TNIK inhibitors using computational high-throughput virtual screening (HTVS)...