Discrete Fourier Transform-Based Multivariate Image Analysis: Application to Modeling of Aromatase Inhibitory Activity [0.03%]
基于离散傅立叶变换的多变量图像分析及其在雌激素受体活性化合物构效关系研究中的应用
Stephen J Barigye,Matheus P Freitas,Priscila Ausina et al.
Stephen J Barigye et al.
We recently generalized the formerly alignment-dependent multivariate image analysis applied to quantitative structure-activity relationships (MIA-QSAR) method through the application of the discrete Fourier transform (DFT), allowing for it...
Application of the Open qPCR Instrument for the in Vitro Selection of DNA Aptamers against Epidermal Growth Factor Receptor and Drosophila C Virus [0.03%]
开放型qPCR仪在体外筛选EGFR和果蝇C病毒DNA适配体的应用研究
Tulsi Ram Damase,Tanya A Miura,Christine E Parent et al.
Tulsi Ram Damase et al.
The low-cost Open qPCR instrument can be used for different tasks in the aptamer selection process: quantification of DNA, cycle course optimization, screening, and final binding characterization. We have selected aptamers against whole Dro...
Application of High-Throughput Seebeck Microprobe Measurements on Thermoelectric Half-Heusler Thin Film Combinatorial Material Libraries [0.03%]
高通量Seebeck微探针测量在热电半赫斯勒薄膜组合材料库中的应用
Pawel Ziolkowski,Matthias Wambach,Alfred Ludwig et al.
Pawel Ziolkowski et al.
In view of the variety and complexity of thermoelectric (TE) material systems, combinatorial approaches to materials development come to the fore for identifying new promising compounds. The success of this approach is related to the availa...
An Old Story in the Parallel Synthesis World: An Approach to Hydantoin Libraries [0.03%]
平行合成世界里的老故事——含硫杂环丁啶类化合物的多样性导向合成
Andrey V Bogolubsky,Yurii S Moroz,Olena Savych et al.
Andrey V Bogolubsky et al.
An approach to the parallel synthesis of hydantoin libraries by reaction of in situ generated 2,2,2-trifluoroethylcarbamates and α-amino esters was developed. To demonstrate utility of the method, a library of 1158 hydantoins designed acco...
Novel Multicomponent Synthesis of Pyridine-Pyrimidines and Their Bis-Derivatives Catalyzed by Triazine Diphosphonium Hydrogen Sulfate Ionic Liquid Supported on Functionalized Nanosilica [0.03%]
功能化纳米 silica 载体三嗪二磷氢硫酸盐离子液体催化多组分合成吡啶-嘧啶及其双衍生物的新方法
Fahime Rahmani,Iraj Mohammadpoor-Baltork,Ahmad Reza Khosropour et al.
Fahime Rahmani et al.
In this Research Article, we report an efficient synthesis of 1,3-dimethyl-5-aryl-7-(pyridine-3(2)(4)-yl)pyrimidine-2,4(1H,3H)-diones via a three-component reaction of aryl aldehydes, 1,3-dimethyl-6-aminouracil and carbonitriles in the pres...
Library-to-Library Synthesis of Highly Substituted α-Aminomethyl Tetrazoles via Ugi Reaction [0.03%]
基于Ugi反应的高 substituted α-aminomethyl tetrazole 的图书馆到图书馆合成法研究
Pravin Patil,Bhupendra Mishra,Gitanjali Sheombarsing et al.
Pravin Patil et al.
α-Aminomethyl tetrazoles, recently made accessible by an Ugi multicomponent reaction (MCR), were shown to be excellent starting materials for a further Ugi MCR, yielding substituted N-methyl-2-(((1-methyl-1H-tetrazol-5-yl)methyl)amino)acet...
Combinatorial Discovery of Lanthanum-Tantalum Oxynitride Solar Light Absorbers with Dilute Nitrogen for Solar Fuel Applications [0.03%]
用于太阳能燃料的掺氮镧-钽氧化物太阳光吸收材料的组合发现
Santosh K Suram,Sean W Fackler,Lan Zhou et al.
Santosh K Suram et al.
Oxynitrides with the photoelectrochemical stability of oxides and desirable band energetics of nitrides comprise a promising class of materials for solar photochemistry. Challenges in synthesizing a wide variety of oxynitride materials has ...
Process-Function Data Mining for the Discovery of Solid-State Iron-Oxide PV [0.03%]
固态铁氧化物PV的工艺功能数据挖掘发现
Elana Borvick,Assaf Y Anderson,Hannah-Noa Barad et al.
Elana Borvick et al.
Data mining tools have been known to be useful for analyzing large material data sets generated by high-throughput methods. Typically, the descriptors used for the analysis are structural descriptors, which can be difficult to obtain and to...
High-Throughput Chemical Probing of Full-Length Protein-Protein Interactions [0.03%]
高效化学探测全长蛋白质-蛋白质相互作用
James M Song,Arya Menon,Dylan C Mitchell et al.
James M Song et al.
Human biology is regulated by a complex network of protein-protein interactions (PPIs), and disruption of this network has been implicated in many diseases. However, the targeting of PPIs remains a challenging area for chemical probe and dr...
Synthesis of 2-Alkoxy/Thioalkoxy Benzo[d]imidazoles and 2-Thione Benzo[d]imidazoles via a Phase-Based, Chemoselective Reaction [0.03%]
基于相的化学选择性反应合成2-烷氧基/硫代烷氧基苯并咪唑和2-噻吨苯并咪唑
Hyo-Jeong Yoon,Seung-Ju Yang,Young-Dae Gong
Hyo-Jeong Yoon
2-Alkoxy/thioalkoxy benzo-[d]-imidazole and 2-thione benzo-[d]-imidazole libraries were constructed in solution phase and on solid phase, respectively. The key step in this work is the phase-based chemoselective reaction of the 2-mercaptobe...