Efficient Access to Imidazo[1,2- a]pyridines/pyrazines/pyrimidines via Catalyst-Free Annulation Reaction under Microwave Irradiation in Green Solvent [0.03%]
一种绿色溶剂中无需催化剂条件下微波促进的含氮杂环化合物的构建反应
R Nishanth Rao,Balamurali Mm,Barnali Maiti et al.
R Nishanth Rao et al.
An expeditious catalyst-free heteroannulation reaction for imidazo[1,2- a]pyridines/pyrimidines/pyrazines was developed in green solvent under microwave irradiation. Using H2O-IPA as the reaction medium, various substituted 2-aminopyridines...
Sortase-Mediated High-Throughput Screening Platform for Directed Enzyme Evolution [0.03%]
用于定向酶进化的排序酶介导的高通量筛选平台
Zhi Zou,Diana M Mate,Kristin Rübsam et al.
Zhi Zou et al.
Sortase-catalyzed ligations have emerged as powerful tools for the site-specific ligation of peptides and proteins in material science and biocatalysis. In this work, a directed sortase evolution strategy (SortEvolve) has been developed as ...
Tiberiu A Burinaru,Marioara Avram,Andrei Avram et al.
Tiberiu A Burinaru et al.
Metastasis is the main cause of death in cancer patients worldwide. During metastasis, cancer cells detach from the primary tumor and invade distant tissue. The cells that undergo this process are called circulating tumor cells (CTCs). Stud...
Crystallographic Structure Analysis of a Ti-Ta Thin Film Materials Library Fabricated by Combinatorial Magnetron Sputtering [0.03%]
利用组合磁控溅射技术制备Ti-Ta薄膜材料库的晶体结构分析
Peter M Kadletz,Yahya Motemani,Joy Iannotta et al.
Peter M Kadletz et al.
Ti-Ta thin films exhibit properties that are of interest for applications as microactuators and as biomedical implants. A Ti-Ta thin film materials library was deposited at T = 25 °C by magnetron sputtering employing the combinatorial appr...
Solid-Phase Synthesis of Oligopeptides Containing Sterically Hindered Amino Acids on Nonswellable Resin Using 3-Nitro-1,2,4-triazol-1-yl-tris(pyrrolidin-1-yl)phosphonium Hexafluorophosphate (PyNTP) as the Condensing Reagent [0.03%]
新型偶联试剂PyNTP用于固相合成非易形树脂结合的环肽及含位阻氨基酸多肽的研究
Rintaro Iwata Hara,Yuta Mitsuhashi,Keita Saito et al.
Rintaro Iwata Hara et al.
Peptides are still difficult to synthesize when they contain sterically hindered amino acids, such as α,α-disubstituted amino acids and N-substituted amino acids. In this study, solid-phase syntheses of oligopeptides containing multiple ...
Mladena Glavaš,Matija Gredičak,Ivanka Jerić
Mladena Glavaš
Multicomponent reactions represent a highly efficient approach to a broad spectrum of structurally diverse compounds starting from simple and affordable compounds. A focused library of tweezers-like compounds is prepared by employing the mu...
Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines [0.03%]
高立体选择性合成稠环螺氧吲哚并噻唑烷化合物的串联多组分策略
Giulia Rainoldi,Fabio Begnini,Mariska de Munnik et al.
Giulia Rainoldi et al.
We developed two Ugi-type three-component reactions of spirooxindole-fused 3-thiazolines, isocyanides, and either carboxylic acids or trimethylsilyl azide, to give highly functionalized spirooxindole-fused thiazolidines. Two diverse librari...
Solid-Phase Synthesis of β-Amino Ketones Via DNA-Compatible Organocatalytic Mannich Reactions [0.03%]
基于DNA的曼尼希反应合成β-氨基酮类化合物
Nam Tran-Hoang,Thomas Kodadek
Nam Tran-Hoang
One-bead-one-compound (OBOC) libraries constructed by solid-phase split-and-pool synthesis are a valuable source of protein ligands. Most OBOC libraries are comprised of oligoamides, particularly peptides, peptoids, and peptoid-inspired mol...
Construction of 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Library with a High Level of Skeletal Diversity Based on Branching Diversity-Oriented Synthesis on Solid-Phase Supports [0.03%]
基于分支多样性的固相支持物导向合成构建具有较高骨架多样性的1,3,4-噁二唑和1,3,4-噻二唑库
Ji-Eun Ha,Seung-Ju Yang,Young-Dae Gong
Ji-Eun Ha
An efficient solid-phase synthetic route for the construction of 1,3,4-oxadiazole and 1,3,4-thiadiazole libraries based on branching diversity-oriented synthesis (DOS) has been developed in this study. The core skeleton resins, 1,3,4-oxadia...
DNA-Compatible Solid-Phase Combinatorial Synthesis of β-Cyanoacrylamides and Related Electrophiles [0.03%]
与DNA相容的固相合成β-氰基丙烯酰胺及其相关亲电子试剂
Kevin Pels,Paige Dickson,Hongchan An et al.
Kevin Pels et al.
We demonstrate that the Knoevenagel condensation can be exploited in combinatorial synthesis on the solid phase. Condensation products from such reactions were structurally characterized, and their Michael reactivity with thiol and phosphin...