Quantitative Single-Cell Analysis of Isolated Cancer Cells with a Microwell Array [0.03%]
微阵列井定量分析分离的癌细胞
Hojun Kim,Sungwook Park,Benedict J Kang et al.
Hojun Kim et al.
The heterogeneous nature of tumor-cell populations suggests that quantitative analysis at the single-cell level may provide better insights into cancer biology. Specifically, detection of multiple biomarkers from a single cell offers import...
Sea Urchin Embryo Model As a Reliable in Vivo Phenotypic Screen to Characterize Selective Antimitotic Molecules. Comparative evaluation of Combretapyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles as Tubulin-Binding Agents [0.03%]
海胆胚胎模型作为可靠的体内表型筛选，用于鉴定选择性抗有丝分裂分子：依他雷因派拉唑、-异噁唑、-1,2,3-三氮唑和-吡咯作为微管结合剂的比较研究
Marina N Semenova,Dmitry V Demchuk,Dmitry V Tsyganov et al.
Marina N Semenova et al.
A series of both novel and reported combretastatin analogues, including diarylpyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles, were synthesized via improved protocols to evaluate their antimitotic antitubulin activity using in vivo ...
Comparative Study
ACS combinatorial science. 2018 Dec 10;20(12):700-721. DOI:10.1021/acscombsci.8b00113 2018
Combating a Master Manipulator: Staphylococcus aureus Immunomodulatory Molecules as Targets for Combinatorial Drug Discovery [0.03%]
打击幕后操纵者：金黄色葡萄球菌免疫调节分子作为组合药物发现的目标
Kadalipura P Rakesh,Manukumar H Marichannegowda,Shobhith Srivastava et al.
Kadalipura P Rakesh et al.
Staphylococcus aureus is a bacterial pathogen that can cause significant disease burden and mortality by counteracting host defenses through producing virulence factors to survive the immune responses evoked by infection. This emerging drug...
Small Library of Triazolyl Polyphenols Correlating Antioxidant Activity and Stability with Number and Position of Hydroxyl Groups [0.03%]
含三氮唑多酚小文库：抗氧化活性与羟基数量及位置的关系以及稳定性研究
Ma Angeles Bonache,Silvia Moreno-Fernández,Marta Miguel et al.
Ma Angeles Bonache et al.
Polyphenolic compounds have attracted much interest because of their antioxidant properties and multiple applications, from food or cosmetic preservatives to free radical scavengers as therapeutic agents. Inspired by common OH substitutions...
(Chlorosulfonyl)benzenesulfonyl Fluorides-Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library [0.03%]
用于组合化学的多功能构建模块氯磺酰基苯磺酰氟的设计、合成与评价：共价抑制剂库
Kateryna A Tolmachova,Yurii S Moroz,Angelika Konovets et al.
Kateryna A Tolmachova et al.
Multigram synthesis of (chlorosulfonyl)benzenesulfonyl fluorides is described. Selective modification of these building blocks at the sulfonyl chloride function under parallel synthesis conditions is achieved. It is shown that the reaction ...
High-Throughput Screening Solar-Thermal Conversion Films in a Pseudobinary (Cr, Fe, V)-(Ta, W) System [0.03%]
高通量筛选(Cr,Fe,V)-(Ta,W)二元体系太阳热转换薄膜
Qiuwei Xing,Jiang Ma,Cong Wang et al.
Qiuwei Xing et al.
The properties and microstructure of (Cr, Fe, V)-(Ta, W) high-entropy films (HEFs) are studied using combinatorial strategies. The compositional library of (Cr0.33Fe0.33V0.33) x(Ta0.5W0.5)100- x, (0 < x < 100), HEFs are fabricated by cosput...
Combinatorial Material Science and Strain Engineering Enabled by Pulsed Laser Deposition Using Radially Segmented Targets [0.03%]
基于径向分段靶的脉冲激光沉积技术实现组合材料科学与应变工程
Max Kneiß,Philipp Storm,Gabriele Benndorf et al.
Max Kneiß et al.
Vertical composition gradients of ternary alloy thin films find applications in numerous device structures. Up to now such gradients along the growth direction have not been realized by standard pulsed laser deposition (PLD) systems. In thi...
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics [0.03%]
基于激酶活性的高通量筛选用于抗癌药物的新颖丙酮酸脱氢酶激酶1(PDK1)抑制剂的鉴定
Wen Zhang,Xiaohui Hu,Harapriya Chakravarty et al.
Wen Zhang et al.
Warburg effect, a preference of aerobic glycolysis for energy production even in the presence of adequate oxygen, is one of the most prominent distinctions of cancer cells from their normal equivalents. Upregulated pyruvate dehydrogenase ki...
Hadassa Y Holzapfel,Alan D Stern,Mehdi Bouhaddou et al.
Hadassa Y Holzapfel et al.
Ultraviolet-to-infrared fluorescence is a versatile and accessible assay modality but is notoriously hard to multiplex due to overlap of wide emission spectra. We present an approach for fluorescence called multiplexing using spectral imagi...
Combinatorial Thin Film Sputtering Au xAl1- x Alloys: Correlating Composition and Structure with Optical Properties [0.03%]
金合金薄膜的组合化学制备及光学性质研究 Aluminium alloys Au x Al (1-x)
Robyn Collette,Yueying Wu,Agust Olafsson et al.
Robyn Collette et al.
The Au-Al alloy system was investigated via a combinatorial thin film sputtering method for its potential as a plasmonic material. Au xAl1- x combinatorial libraries were cosputtered from Au and Al elemental targets and the composition, pha...