Mild and Efficient Palladium-Mediated C-N Cross-Coupling Reaction between DNA-Conjugated Aryl Bromides and Aromatic Amines [0.03%]
用于DNA连接的芳基溴和芳香胺的 palladium催化的C-N交叉偶联反应
Eduardo de Pedro Beato,Julián Priego,Adrián Gironda-Martínez et al.
Eduardo de Pedro Beato et al.
DNA-encoded library technology (ELT) has emerged in the pharmaceutical industry as a powerful tool for hit and lead generation. Over the last 10 years, a number of DNA-compatible chemical reactions have been published and used to synthesize...
Post-Glycosylation Diversification (PGD): An Approach for Assembling Collections of Glycosylated Small Molecules [0.03%]
糖基化后分化(PGD)：组装糖基化小分子系列的方法
Zachary Cannone,Ala M Shaqra,Chris Lorenc et al.
Zachary Cannone et al.
Many small molecule natural products with antibiotic and antiproliferative activity are adorned with a carbohydrate residue as part of their molecular structure. The carbohydrate moiety can act to mediate key interactions with the target, a...
Chemo-Diversification of Plant Extracts Using a Generic Bromination Reaction and Monitoring by Metabolite Profiling [0.03%]
基于溴化通用反应的植物提取物化学多样化及代谢轮廓监测法
Davide Righi,Laurence Marcourt,Alexey Koval et al.
Davide Righi et al.
A generic procedure for direct bromination of polyphenol in crude plant extracts was developed to generate multiple "unnatural" halogenated natural products for further bioassay evaluation. To better control the halogenation procedure, the ...
E P Aparna,K S Devaky
E P Aparna
This Review describes the existing synthetic approaches for the solid-phase synthesis (SPS) of differently substituted and fused pyrimidine derivatives. These synthetic strategies are classified on the basis of the different synthetic route...
Exploration of Catalytic Nucleic Acids on Porphyrin Metalation and Peroxidase Activity by in Vitro Selection of Aptamers for N-Methyl Mesoporphyrin IX [0.03%]
基于IX型N-甲基中孔原卟啉体外筛选适配体对卟啉金属化和辣根过氧化物酶活性催化作用的探索研究
Luyan Yang,Pi Ding,Yu Luo et al.
Luyan Yang et al.
To develop a novel light-up probe and DNAzyme, we selected aptamers for N-methyl mesoporphyrin IX (NMM), a common fluorogenic analogue of coenzyme hemin, by a modified affinity chromatography-based systematic evolution of ligands by exponen...
FTIR Spectroscopy Suggests a Revised Mode of Action for the Cationic Side-Chain Effect of Ionic Liquids [0.03%]
傅立叶变换红外光谱法对离子液体阳离子侧链效应作用模式的新认识
Patrick Mester,Christian Robben,Anna K Witte et al.
Patrick Mester et al.
Over the past decades, ionic liquids (ILs) have gained considerable attention from the scientific community because of their versatile and designable properties. As a result, there are numerous IL applications, not only in organic synthesis...
Synthesis of D-Ring Annulated Pyridosteroids from β-Formyl Enamides and Their Biological Evaluations [0.03%]
β-_formyl烯胺衍生物的D_环并环吡啶甾族化合物合成及其生物活性研究
Geetmani Singh Nongthombam,Kasmika Borah,Thingreila Muinao et al.
Geetmani Singh Nongthombam et al.
Herein, we report the synthesis of a novel class of substituted androst[17,16- b]pyridines (pyridosteroids) from the reaction of β-formyl enamides with alkynes in high yields. The optimized reaction protocol was extended to acyclic and cyc...
Josipa Suć Sajko,Vanja Ljoljić Bilić,Ivan Kosalec et al.
Josipa Suć Sajko et al.
The γ-lactam motif is often found in naturally occurring compounds with diverse biological activities. We prepared a 28-member library of N-substituted γ-lactams following a single-pot, three-component Ugi reaction comprising bifunctional...
Combinatorial Peptide Microarray Synthesis Based on Microfluidic Impact Printing [0.03%]
基于微流体冲击打印的组合肽芯片合成法
Jiannan Li,Siwei Zhao,Gaomai Yang et al.
Jiannan Li et al.
In this Research Article, a novel inkjet printing technique, micro impact printing (MI printing), is applied for the first time to combinatorial peptide microarray synthesis on amine functionalized microdisc arrays through standard Fmoc che...
Traceless Solid-Phase Synthesis of 1' H-Spiro[Pyrrolidine-3,2'-quinazolin]-2-ones and 1' H-Spiro[Piperidine-3,2'-quinazolin]-2-ones via Lactamization of 1,2-Dihydroquinazoline-2-carboxylates [0.03%]
1',H-螺环[吡咯烷-3,2'-呫吨]-2-酮和1',H-螺环[哌啶-3,2'-呫吨]-2-酮的无保护基固相合成及其内酰胺化反应副产物的研究
Jana Pospíšilová,Viktor Krchňák,Eva Schütznerová
Jana Pospíšilová
We present the solid-phase synthesis of 1,2-dihydroquinazoline-2-carboxylate derivatives with a quaternary carbon in position 2 and their subsequent cyclization in solution into compounds with unique 3D architectures and pharmacological rel...