Synthesis of Benz-Fused Azoles via C-Heteroatom Coupling Reactions Catalyzed by Cu(I) in the Presence of Glycosyltriazole Ligands [0.03%]
糖基三氮唑配体存在下铜(I)催化C-杂原子偶联反应合成苯并杂环azole类化合物
Nidhi Mishra,Anoop S Singh,Anand K Agrahari et al.
Nidhi Mishra et al.
Glycosyl triazoles are conveniently accessible and contain multiple metal-binding units that may assist in metal-mediated catalysis. Azide derivatives of d-glucose have been converted to their respective aryltriazoles and screened as ligand...
Early Years of High-Throughput Experimentation and Combinatorial Approaches in Catalysis and Materials Science [0.03%]
催化和材料科学中的高通量实验及组合方法的早期发展
Wilhelm F Maier
Wilhelm F Maier
This is a report on the early years of combinatorial materials science and technology. High-throughput technologies (HTTs) are found in life- and materials-science laboratories. Although HTTs have long been the standard in life sciences in ...
Intramolecular Electrophilic Cyclization Approach to 6-Substituted Naphtho[2,1- b]benzofurans: Novel Dual-State Emissive Fluorophores with Blue Emission [0.03%]
6-位取代萘并苯并呋喃的分子内亲电环化合成方法：一种新型双态发射蓝色荧光材料
Dileep Kumar Singh,Kyungkuk Jang,Jinhwang Kim et al.
Dileep Kumar Singh et al.
A regiospecific synthesis of naphtho[2,1- b]benzofurans with a substituent at the C6 position was achieved via intramolecular 6-endo-dig electrophilic cyclization under acidic conditions to construct the central aromatic C ring. Screening o...
Polymerase-Extension-Based Selection Method for DNA-Encoded Chemical Libraries against Nonimmobilized Protein Targets [0.03%]
基于聚合酶延伸的DNA编码化学文库非固相蛋白靶点筛选方法
Bingbing Shi,Yuqing Deng,Xiaoyu Li
Bingbing Shi
DNA-encoded chemical libraries (DELs) have become an important ligand discovery technology in biomedical research and drug discovery. DELs can be comprised of hundreds of millions to billions of candidate molecules and provide outstanding c...
Optimization of the Anodization Processing for Aluminum Oxide Gate Dielectrics in ZnO Thin Film Transistors by Multivariate Analysis [0.03%]
基于多变量分析的ZnO薄膜晶体管中Al₂O₃栅极绝缘层阳极氧化工艺优化研究
Tiago C Gomes,Dinesh Kumar,Lucas Fugikawa-Santos et al.
Tiago C Gomes et al.
The present study reports a two-level multivariate analysis to optimize the production of anodized aluminum oxide (Al2O3) dielectric films for zinc oxide thin-film transistors (TFTs). Fourteen performance parameters were measured and analys...
An Inter-Laboratory Study of Zn-Sn-Ti-O Thin Films using High-Throughput Experimental Methods [0.03%]
基于高通量实验方法的Zn-Sn-Ti-O薄膜联合实验室研究
Jason R Hattrick-Simpers,Andriy Zakutayev,Sara C Barron et al.
Jason R Hattrick-Simpers et al.
High-throughput experimental (HTE) techniques are an increasingly important way to accelerate the rate of materials research and development for many technological applications. However, there are very few publications on the reproducibilit...
Comparative Study
ACS combinatorial science. 2019 May 13;21(5):350-361. DOI:10.1021/acscombsci.8b00158 2019
Wesley G Cochrane,Marie L Malone,Vuong Q Dang et al.
Wesley G Cochrane et al.
Robotic high-throughput compound screening (HTS) and, increasingly, DNA-encoded library (DEL) screening are driving bioactive chemical matter discovery in the postgenomic era. HTS enables activity-based investigation of highly complex targe...
Synthesis of 2-Amino-5-Carboxamide Thiazole Derivatives via Dehydrative Cyclization of Thiourea Intermediate Resin on Solid Phase [0.03%]
通过固体支持的硫脲中间体脱水环化合成2-氨基-5-碳二亚胺噻唑衍生物
Ye-Ji Kim,Hye-Jin Kwon,Si-Yeon Han et al.
Ye-Ji Kim et al.
In this study, we synthesized 2-amino-5-carboxamide thiazole derivatives on solid phase. The synthesis of the library starts with the reductive amination of the 4-formyl-3-methoxy phenoxy resin to prevent isomer formation. The dehydrative c...
Development of a High-Throughput Screening Method for Oxide-Ion Conductors and Its Application to Bismuth-Based Oxide Library Thin Films [0.03%]
氧化物离子导体的高通量筛选方法开发及其在铋系氧化物薄膜库中的应用研究
Masato Matsubara,Akitoshi Suzumura,Shin Tajima et al.
Masato Matsubara et al.
To accelerate material discovery, we develop a screening method for oxide-ion conductors that comprises combinatorial synthesis using chemical-solution deposition and high-throughput measurements using X-ray diffraction and conductivity. Th...
Enantioselective Synthesis of Hydantoin and Diketopiperazine-Fused Tetrahydroisoquinolines via Pictet-Spengler Reaction [0.03%]
脯氨酰胺介导的皮克特-施彭格尔反应构建四氢异喹啉骨架化合物的研究
Shih-I Liu,Jia-Yun Haung,Indrajeet J Barve et al.
Shih-I Liu et al.
An enantioselective synthesis of iso-, isothio-, and isoselenohydantoin and diketopiperazine-fused tetrahydroisoquinolines from l-Dopa was reported. The route consists of an Pictet-Spengler reaction of ( S)-2-amino-3-(3,4-dimethoxyphenyl)pr...