Click Chemistry-Mediated Complementation Assay for RNA-Protein Interactions [0.03%]
基于点击化学的RNA-蛋白质互作检测方法
Emily J Sherman,Daniel A Lorenz,Amanda L Garner
Emily J Sherman
Click chemistry-based assays are a growing class of biochemical assay for facilitating the discovery of modulators of important biological processes. To date, most have relied on the use of immobilized biomolecules, which increases the cost...
New One-Pot Synthesis of 1,3,5-Triazines: Three-Component Condensation, Dimroth Rearrangement, and Dehydrogenative Aromatization [0.03%]
1,3,5-三嗪的新一锅合成法：三组分缩合、Dimroth重排和脱氢芳构化
Ahmad Junaid,Felicia Phei Lin Lim,Edward R T Tiekink et al.
Ahmad Junaid et al.
A new, effective one-pot synthesis of the 6, N2-diaryl-1,3,5-triazine-2,4-diamines under microwave irradiation was developed. The method involved an initial three-component condensation of cyanoguanidine, aromatic aldehydes, and arylamines ...
Spray Pyrolysis as a Combinatorial Method for the Generation of Photocatalyst Libraries [0.03%]
喷雾热解作为光催化剂库生成的组合方法
Jordan S Compton,Christi A Peterson,Dilek Dervishogullari et al.
Jordan S Compton et al.
An inexpensive, combinatorial method to evaluate an array of metal oxide materials as photocatalysts for solar fuel production utilizing spray pyrolysis is presented. This new approach capitalizes on the inherent properties of spray pyrolys...
Kevin R Talley,Sage R Bauers,Celeste L Melamed et al.
Kevin R Talley et al.
Combinatorial experiments involve synthesis of sample libraries with lateral composition gradients requiring spatially resolved characterization of structure and properties. Because of the maturation of combinatorial methods and their succe...
Realization of Spatially Addressable Library by a Novel Combinatorial Approach on Atomic Layer Deposition: A Case Study of Zinc Oxide [0.03%]
基于原子层沉积的新型组合方法实现空间地址式化合物库：以氧化锌为例
Harrison Sejoon Kim,Joy S Lee,Si Joon Kim et al.
Harrison Sejoon Kim et al.
Though the synthesis of libraries of multicomponent metal oxide systems is prevalent using the combinatorial approach, the combinatorial approach has been rarely realized in studying simple metal oxides, especially applied to the atomic lay...
Molecular Imaging of Retinoic Acids in Live Cells Using Single-Chain Bioluminescence Probes [0.03%]
用于活细胞视黄酸分子成像的单链生物发光探针
Sung Bae Kim,Rika Fujii,Ryo Nishihara et al.
Sung Bae Kim et al.
Retinoic acid (RA) is a key metabolite necessary for embryonic development and differentiation in vertebrates. We demonstrate the utility of genetically encoded, ligand-activatable single-chain bioluminescence probes for detecting RAs from ...
Compensated Interferometry Measures of CYFRA 21-1 Improve Diagnosis of Lung Cancer [0.03%]
基于CYFRA 21-1补偿化干涉测量法的肺癌诊断方法研究
Michael N Kammer,Amanda K Kussrow,Rebekah L Webster et al.
Michael N Kammer et al.
Diagnosis of lung cancer patients with indeterminate pulmonary nodules (IPNs) presents a significant clinical challenge, with morbidity and management costs of $28 billion/year. We show that a quantitative free-solution assay (FSA), coupled...
Design and Solid-Phase Parallel Synthesis of 2,4,5-Trisubstituted Thiazole Derivatives via Cyclization Reaction with a Carbamimidothioate Linker [0.03%]
含碳氨亚硫化物连接臂的环化反应合成三取代噻唑类化合物的研究及固相平行合成方法学研究
Hye-Jin Kwon,Ye-Ji Kim,Si-Yeon Han et al.
Hye-Jin Kwon et al.
Preparation of 2,4,5-trisubstituted thiazole derivatives via a new solid-phase synthetic route has been conducted in this study. The synthetic route begins with the synthesis of a core skeleton 2,4-diamino(thiazol-5-yl)-substituted phenylme...
Copper-Promoted C-Se Cross-Coupling of 2-Selenohydantoins with Arylboronic Acids in an Open Flask [0.03%]
敞开式烧瓶中二硒基氢坦酮与芳基硼酸的铜催化交叉偶联反应生成C-Se键
Oleksandr Vyhivskyi,Egor A Dlin,Alexander V Finko et al.
Oleksandr Vyhivskyi et al.
The modification of Chan-Lam-Evans cross-coupling reaction for the selective Se-arylation of 2-selenohydantoins under base-free mild conditions via aryl boronic acids is described herein. This approach was used to synthesize novel 5-arylide...
Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors [0.03%]
基于聚合物微阵列的 robust 光纤 pH 传感器的发现与优化
Jingjing Gong,Seshasailam Venkateswaran,Michael G Tanner et al.
Jingjing Gong et al.
Polymer microarrays were utilized for the high-throughput screening and discovery of optimal polymeric substrates capable of trapping functional ratiometric fluorescence-based pH sensors. This led to the identification of poly(methyl methac...